Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics
Tejero E, Mao Q, Lashgari D, García-Valiente R, Robert P, Meyer-Hermann M, Martínez M, Guikema J, Hoefsloot H, van Kampen A. Multi-Scale Modeling Recapitulates the Effect of Genetic Alterations Associated With Diffuse Large B-Cell Lymphoma in the Germinal Center Dynamics. Frontiers In Systems Biology 2022, 2: 864690. DOI: 10.3389/fsysb.2022.864690.Peer-Reviewed Original ResearchDiffuse large B-cell lymphomaLarge B-cell lymphomaB-cell lymphoma 6B-cell lymphomaB lymphocyte-induced maturation protein-1B cell lymphoma 6 expressionInterferon regulatory factor 4B cellsGC reactionPC differentiationTranscription factor dynamicsPlasma cellsSubtype of non-Hodgkin lymphomaAccumulation of B cellsGC B cell phenotypeFactor kappa-light-chain-enhancer of activated B cellsNon-Hodgkin's lymphomaNuclear factor kappa-light-chain-enhancer of activated B cellsNuclear factor kappa-light-chain-enhancerB-cell phenotypeGC B cell populationB cell populationsGC B cellsB cell differentiationRegulatory factor 4