2020
Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts
Pélissier A, Akrout Y, Jahn K, Kuipers J, Klein U, Beerenwinkel N, Martínez M. Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts. Cells 2020, 9: 1448. PMID: 32532145, PMCID: PMC7349200, DOI: 10.3390/cells9061448.Peer-Reviewed Original ResearchConceptsClonal diversityB cell receptorSequence of nucleotidesEvolutionary phylogenetic treesGC dynamicsIn silico vaccine designPhylogenetic treeClonal dominanceAffinity to antigenB cell differentiationSpecialized compartmentsAntibody genesGenetic eventsInterclonal competitionClonal burstEvolutionary processB cell maturationIntracellular componentsB-cell variantsClonal dynamicsSomatic hypermutationB cellsIncreased affinityAffinity maturationGerminal centers
2019
A Probabilistic Model of the Germinal Center Reaction
Thomas M, Klein U, Lygeros J, Martínez M. A Probabilistic Model of the Germinal Center Reaction. Frontiers In Immunology 2019, 10: 689. PMID: 31001283, PMCID: PMC6456718, DOI: 10.3389/fimmu.2019.00689.Peer-Reviewed Original ResearchConceptsB cell differentiationMemory B cell differentiationSpecialized compartmentsAntibody genesPlasma cell differentiationFate selectionB cellsIndividual cell propertiesCell differentiationB cell maturationMolecular eventsEfficient stochastic simulationExtracellular dynamicsQuantitative stochastic modelMemory B cell formationAntigen affinityB cell formationGillespie algorithmDifferentiationCell propertiesCell productionMemory B cells