2016
Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration
Vasunilashorn SM, Marcantonio ER, Gou Y, Pisani MA, Travison TG, Schmitt EM, Jones RN, Inouye SK. Quantifying the Severity of a Delirium Episode Throughout Hospitalization: the Combined Importance of Intensity and Duration. Journal Of General Internal Medicine 2016, 31: 1164-1171. PMID: 27259291, PMCID: PMC5023588, DOI: 10.1007/s11606-016-3671-9.Peer-Reviewed Original ResearchConceptsPost-hospital outcomesDelirium intensitySeverity measuresEpisode of deliriumPoor clinical outcomeDelirium durationDelirium episodesEntire hospitalizationAdult patientsClinical outcomesDelirium severityRelative riskIndependent cohortDeliriumStrong associationOutcomesHospitalizationCognitive changesDurationSeverityPredictive validityEpisodesAssociationCombined importancePatients
2015
Functional Trajectories Among Older Persons Before and After Critical Illness
Ferrante LE, Pisani MA, Murphy TE, Gahbauer EA, Leo-Summers LS, Gill TM. Functional Trajectories Among Older Persons Before and After Critical Illness. JAMA Internal Medicine 2015, 175: 523-529. PMID: 25665067, PMCID: PMC4467795, DOI: 10.1001/jamainternmed.2014.7889.Peer-Reviewed Original ResearchConceptsIntensive care unitLong-term mortalityCritical illnessICU admissionModerate disabilityOlder personsMinimal disabilitySevere disabilityFunctional trajectoriesFunctional declineEarly deathProspective cohort studyDay of admissionPersons 70 yearsGoals of careRisk of deathShort-term mortalityGreater New HavenSignificant functional declineICU lengthCohort studyHospital dischargePremorbid disabilityCare unitMechanical ventilation
2007
The Association between Treatment Preferences and Trajectories of Care at the End-of-Life
Cosgriff JA, Pisani M, Bradley EH, O’Leary J, Fried TR. The Association between Treatment Preferences and Trajectories of Care at the End-of-Life. Journal Of General Internal Medicine 2007, 22: 1566-1571. PMID: 17874168, PMCID: PMC2219807, DOI: 10.1007/s11606-007-0362-6.Peer-Reviewed Original ResearchConceptsTreatment preferencesLife careIntensive treatmentAcute processAggressive careSymptomatic reliefTrajectories of endUnwanted aggressive careRelief of symptomsPatients' treatment preferencesDirection of patientsTrajectory of careHigh-quality endAdvanced diseaseSymptom controlConclusionsThe associationAssociations of preferenceIntensive interventionCarePatientsLife prolongationTreatmentPerson's ageReliefAssociation