Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma
Ingram J, McQuade V, Weiss J, Womble J, Ihrie M, Zhao K, Francisco D, Theriot B, May K, Kim H, McCravy M, Sauler M, Lugogo N, Sunday M, Everitt J, Walker J, Tighe R, Kraft M, Que L. Leptin augments IL-13-induced airway eotaxins and submucosal eosinophilia in obesity-associated asthma. Journal Of Allergy And Clinical Immunology 2024 PMID: 39581293, DOI: 10.1016/j.jaci.2024.10.039.Peer-Reviewed Original ResearchAirway tissue eosinophiliaBronchoalveolar lavage fluidEotaxin productionHuman airway fibroblastsT2 asthmaAirway fibroblastsIL-13Ra2Tissue eosinophiliaMouse model of chronic allergic airways diseaseEotaxin-1Interleukin-13 receptor alpha 2Chronic allergic airway diseaseNeutralizing antibodies in vitroObesity-associated asthmaLung tissue eosinophiliaConcentration of exhaled nitric oxideFractional concentration of exhaled nitric oxideAllergic airway diseaseEotaxin-1 levelsExhaled nitric oxideBody mass indexAntibodies in vitroHouse dust mite allergen exposureCombined leptinIL13RA2 expression