2009
A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics
Champion EA, Kundrat L, Regan L, Baserga SJ. A structural model for the HAT domain of Utp6 incorporating bioinformatics and genetics. Protein Engineering Design And Selection 2009, 22: 431-439. PMID: 19515729, PMCID: PMC2699269, DOI: 10.1093/protein/gzp022.Peer-Reviewed Original ResearchConceptsHAT domainRepeat motifsTetratricopeptide repeat (TPR) motifsKey functional rolesStructure-function relationshipsRNA metabolismLoss of functionMutagenesis studiesInteraction surfaceHomology modelingTertiary structureHomology modelFunctional roleMotifResiduesUTP6BioinformaticsProteinStructural contextDirect effectDomainMutagenesisGeneticsFunction mapsMutations
2008
A Novel Class of Small Molecule Inhibitors of Hsp90
Yi F, Regan L. A Novel Class of Small Molecule Inhibitors of Hsp90. ACS Chemical Biology 2008, 3: 645-654. PMID: 18785742, PMCID: PMC3282108, DOI: 10.1021/cb800162x.Peer-Reviewed Original ResearchConceptsGrowth-promoting proteinsChaperone heat shock protein 90Unregulated cellular proliferationHeat shock protein 90Inhibition of Hsp90Hydrolysis of ATPHuman breast cancer cell lines BT474Small molecule inhibitorsBreast cancer cell line BT474Hsp90 functionMultichaperone complexCorrect foldingAlphaScreen technologyProtein 90Hsp90Cell deathMolecule inhibitorsCell line BT474ATP analogCellular proliferationProteinNovel classCochaperonesApplicable strategyAnticancer agents