Association of Undernutrition With Mortality and Amputation Outcomes in Chronic Limb Threatening Ischaemia: A Systematic Review
Scierka L, Cleman J, Brice A, Grimshaw A, Soedamah-Muthu S, Mena-Hurtado C, Smolderen K. Association of Undernutrition With Mortality and Amputation Outcomes in Chronic Limb Threatening Ischaemia: A Systematic Review. European Journal Of Vascular And Endovascular Surgery 2024 PMID: 39216793, DOI: 10.1016/j.ejvs.2024.08.038.Peer-Reviewed Original ResearchChronic limb-threatening ischaemiaNutritional screening toolsLimb-threatening ischaemiaRisk of deathValidity of nutrition screening toolsSystematic reviewScreening toolEffect sizeStatistically significant increased riskNutritional statusIndicators of undernutritionModifiable risk factorsStatistically significant increased risk of deathRandomised controlled trialsQuality of evidenceCertainty of evidenceNutritional status measuresIncreased risk of deathCase-control studySystematic literature searchAmputation outcomesStatus measuresCase-control study of patientsData extractionCohort studyComparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease
Cleman J, Sierra J, Romain G, Capuano B, Scierka L, Callegari S, Jacque F, Peri-Okonny P, Nagpal S, Smolderen K, Mena-Hurtado C. Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease. Journal Of Vascular Surgery 2024, 80: 480-489.e5. PMID: 38608966, DOI: 10.1016/j.jvs.2024.04.016.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAll-cause mortalityLower extremity bypassPeripheral vascular interventionsComorbid chronic kidney diseaseLimb-threatening ischemiaComparison of mortalityPreference-sensitive treatment decisionsCox proportional hazards modelsRisk of deathInteraction termsProportional hazards modelLower-extremity bypassChronic kidney diseaseFine-Gray modelMortality riskVascular interventionsAmputationHazards modelOutcome dataFine-GrayAssociated with worse outcomesHigh riskKidney diseasePropensity scoreVariability in guideline-directed medical therapy across sites and operators and long-term mortality and amputation outcomes risk in patients undergoing peripheral vascular interventions
Smolderen K, Romain G, Cleman J, Scierka L, Mena-Hurtado C. Variability in guideline-directed medical therapy across sites and operators and long-term mortality and amputation outcomes risk in patients undergoing peripheral vascular interventions. American Heart Journal 2024, 270: 75-85. PMID: 38307364, DOI: 10.1016/j.ahj.2024.01.008.Peer-Reviewed Original ResearchMedian odds ratioGuideline-directed medical therapy prescriptionGuideline-directed medical therapy ratesPeripheral vascular interventionsGuideline-directed medical therapyIntraclass correlationHealth system levelDecrease hospital readmissionsPatient-level factorsGuideline-directed medical therapy useAssociated with higher riskAngiotensin-converting enzyme inhibitor/angiotensin receptor blockerRisk of deathParametric survival modelsInhibitor/angiotensin receptor blockerProportion of riskHospital readmissionVascular Quality Initiative registryLong-term mortalityOdds ratioReadmission riskVascular interventionsLogistic regressionDose-response relationshipAmputation