Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin
Marukian NV, Levinsohn JL, Craiglow BG, Milstone LM, Choate KA. Palmoplantar Keratoderma in Costello Syndrome Responsive to Acitretin. Pediatric Dermatology 2016, 34: 160-162. PMID: 28008647, DOI: 10.1111/pde.13057.Peer-Reviewed Original ResearchConceptsCostello syndromePalmoplantar keratodermaCoarse facial featuresMultisystem congenital disorderSevere palmoplantar keratodermaDermatologic findingsAcanthosis nigricansKeratosis pilarisSystemic administrationSevere casesCardiac defectsCutaneous papillomasSkin redundancyCongenital disorderIntellectual disabilityAcitretinFunctional consequencesKeratodermaPatientsMalignancyPapillomasPilarisSyndromeAdministrationFacial features