2016
International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels
Kaczmarek LK, Aldrich RW, Chandy KG, Grissmer S, Wei AD, Wulff H. International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels. Pharmacological Reviews 2016, 69: 1-11. PMID: 28267675, PMCID: PMC11060434, DOI: 10.1124/pr.116.012864.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumChloridesHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsIon Channel GatingLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsMalePotassium ChannelsPotassium Channels, Calcium-ActivatedSodiumSpermatozoaTerminology as Topic
2012
De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy
Barcia G, Fleming MR, Deligniere A, Gazula VR, Brown MR, Langouet M, Chen H, Kronengold J, Abhyankar A, Cilio R, Nitschke P, Kaminska A, Boddaert N, Casanova JL, Desguerre I, Munnich A, Dulac O, Kaczmarek LK, Colleaux L, Nabbout R. De novo gain-of-function KCNT1 channel mutations cause malignant migrating partial seizures of infancy. Nature Genetics 2012, 44: 1255-1259. PMID: 23086397, PMCID: PMC3687547, DOI: 10.1038/ng.2441.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedElectroencephalographyEpilepsies, PartialExomeHumansInfantInfant, NewbornIntermediate-Conductance Calcium-Activated Potassium ChannelsMiceMutationNeuronsPhosphorylationProtein Kinase CRatsSignal TransductionXenopus
2001
Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels*
Joiner W, Khanna R, Schlichter L, Kaczmarek L. Calmodulin Regulates Assembly and Trafficking of SK4/IK1 Ca2+-activated K+ Channels*. Journal Of Biological Chemistry 2001, 276: 37980-37985. PMID: 11495911, DOI: 10.1074/jbc.m104965200.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalciumCalmodulinCHO CellsCricetinaeFluorescent Antibody TechniqueHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsMutagenesisPatch-Clamp TechniquesPotassium ChannelsPotassium Channels, Calcium-ActivatedProtein BindingProtein TransportConceptsChannel assemblyC-terminusAssembly of channelsIon channelsC-terminal domainDistal C-terminal domainCo-immunoprecipitation experimentsCaM-binding domainSurface expressionDominant negative effectProximal C-terminusWhole-cell currentsCellular functionsCaM genesPlasma membraneCaM proteinFree CaMNovel mechanismTraffickingProteinTerminusAssemblyExpressionSK4Domain
1999
hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes ROLES IN PROLIFERATION AND VOLUME REGULATION*
Khanna R, Chang M, Joiner W, Kaczmarek L, Schlichter L. hSK4/hIK1, a Calmodulin-binding KCa Channel in Human T Lymphocytes ROLES IN PROLIFERATION AND VOLUME REGULATION*. Journal Of Biological Chemistry 1999, 274: 14838-14849. PMID: 10329683, DOI: 10.1074/jbc.274.21.14838.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCalmodulinCell DivisionCHO CellsCricetinaeHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsKv1.3 Potassium ChannelMembrane PotentialsPotassium ChannelsPotassium Channels, Calcium-ActivatedPotassium Channels, Voltage-GatedRNA, MessengerT-LymphocytesUp-RegulationConceptsIK currentsActivated T cell functionSecondary immune responseNaive T cellsT cell functionPromising therapeutic targetChinese hamster ovary cellsHamster ovary cellsHuman T lymphocytesVolume regulationKCa channelsT cellsT lymphocytesImmune responseTherapeutic targetIK blockHSK4Accessory moleculesHuman T lymphoblastsOvary cellsDistal C-terminusPharmacological propertiesT lymphoblastsCell functionProximal C-terminus
1998
Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits
Joiner W, Tang M, Wang L, Dworetzky S, Boissard C, Gan L, Gribkoff V, Kaczmarek L. Formation of intermediate-conductance calcium-activated potassium channels by interaction of Slack and Slo subunits. Nature Neuroscience 1998, 1: 462-469. PMID: 10196543, DOI: 10.1038/2176.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCaenorhabditis elegansCaenorhabditis elegans ProteinsElectric ConductivityIntermediate-Conductance Calcium-Activated Potassium ChannelsIsomerismLarge-Conductance Calcium-Activated Potassium ChannelsMolecular Sequence DataNerve Tissue ProteinsPotassium ChannelsPotassium Channels, Calcium-ActivatedPotassium Channels, Sodium-ActivatedConceptsCalcium-activated potassium channelsIntracellular calciumNervous systemIntermediate-conductance calcium-activated potassium channelsPotassium channelsLarge-conductance calcium-activated potassium channelsControl of excitabilitySlo subunitIntermediate conductance channelPotassium channel genesPharmacological propertiesIntermediate conductanceCytoplasmic calciumChannel subunitsSlo channelsSlack channelsChannel genesSingle-channel conductanceUnitary conductanceCalciumExcitabilitySLOSecretion
1997
hSK4, a member of a novel subfamily of calcium-activated potassium channels
Joiner W, Wang L, Tang M, Kaczmarek L. hSK4, a member of a novel subfamily of calcium-activated potassium channels. Proceedings Of The National Academy Of Sciences Of The United States Of America 1997, 94: 11013-11018. PMID: 9380751, PMCID: PMC23566, DOI: 10.1073/pnas.94.20.11013.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBariumCalciumCHO CellsCloning, MolecularCricetinaeHumansIntermediate-Conductance Calcium-Activated Potassium ChannelsMolecular Sequence DataPotassium ChannelsPotassium Channels, Calcium-ActivatedSequence Homology, Amino AcidConceptsCalcium-activated potassium channelsSK channelsSmall-conductance calcium-activated potassium channelsPotassium channelsHSK4Novel subfamilyAdult animalsPredominant expressionLeucine zipper-like domainChinese hamster ovary cellsNonexcitable tissuesHamster ovary cellsChannel polypeptideOvary cellsLow homologyC-terminusHigh affinityUnknown function