2021
The cavernous carotid inferolateral trunk and persistent primitive maxillary arteries: analysis of dissected arterially injected fetal specimens and high-resolution micro-CT of the dog’s anastomotic arteries
Kier EL, Conlogue GJ, Staib LH. The cavernous carotid inferolateral trunk and persistent primitive maxillary arteries: analysis of dissected arterially injected fetal specimens and high-resolution micro-CT of the dog’s anastomotic arteries. Surgical And Radiologic Anatomy 2021, 43: 1969-1977. PMID: 34091716, PMCID: PMC8536623, DOI: 10.1007/s00276-021-02778-7.Peer-Reviewed Original ResearchConceptsMaxillary arteryInferolateral trunkAnastomotic arteryPrimitive maxillary arteryFetal specimensHuman fetal arteriesDissected specimensFetal arteriesTrunk arteryBrain arteriesCranial circulationArteryDog arteriesHomologous arterySkull baseEmbryologic developmentMethodsThe literatureCT imagingPurposeThe presenceConclusionThis investigationFetal dissectionsDogsHuman arteriesDissectionSpecimen dissection
2020
Sparse Data–Driven Learning for Effective and Efficient Biomedical Image Segmentation
Onofrey JA, Staib LH, Huang X, Zhang F, Papademetris X, Metaxas D, Rueckert D, Duncan JS. Sparse Data–Driven Learning for Effective and Efficient Biomedical Image Segmentation. Annual Review Of Biomedical Engineering 2020, 22: 1-27. PMID: 32169002, PMCID: PMC9351438, DOI: 10.1146/annurev-bioeng-060418-052147.Peer-Reviewed Original ResearchRegional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress
Stendahl JC, Parajuli N, Lu A, Boutagy NE, Guerrera N, Alkhalil I, Lin BA, Staib LH, O’Donnell M, Duncan JS, Sinusas AJ. Regional myocardial strain analysis via 2D speckle tracking echocardiography: validation with sonomicrometry and correlation with regional blood flow in the presence of graded coronary stenoses and dobutamine stress. Cardiovascular Ultrasound 2020, 18: 2. PMID: 31941514, PMCID: PMC6964036, DOI: 10.1186/s12947-019-0183-x.Peer-Reviewed Original ResearchConceptsSpeckle tracking echocardiographyLow-dose dobutamine stressPost-systolic indexDobutamine stressCoronary stenosisBlood flow measurementsTracking echocardiographyAnesthetized open-chest dogsCircumferential strainLow-dose dobutamineMid-left anteriorModerate coronary stenosisOpen-chest dogsRegional blood flowAcute canine modelMyocardial strain analysisMicrosphere blood flow measurementsLAD stenosis
2018
Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size
Johnson MB, Sun X, Kodani A, Borges-Monroy R, Girskis KM, Ryu SC, Wang PP, Patel K, Gonzalez DM, Woo YM, Yan Z, Liang B, Smith RS, Chatterjee M, Coman D, Papademetris X, Staib LH, Hyder F, Mandeville JB, Grant PE, Im K, Kwak H, Engelhardt JF, Walsh CA, Bae BI. Aspm knockout ferret reveals an evolutionary mechanism governing cerebral cortical size. Nature 2018, 556: 370-375. PMID: 29643508, PMCID: PMC6095461, DOI: 10.1038/s41586-018-0035-0.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBiological EvolutionCalmodulin-Binding ProteinsCentrosomeCerebral CortexDisease Models, AnimalFemaleFerretsGene DeletionGene EditingGene Expression Regulation, DevelopmentalGene Knockout TechniquesGerm-Line MutationHumansMaleMiceMicrocephalyNerve Tissue ProteinsNeural Stem CellsOrgan SizeTranscription, GeneticConceptsVentricular radial glial cellsEvolutionary mechanismsRadial glial cellsOuter radial gliaHuman primary microcephalyProtein sequence homologyAbnormal spindle-like microcephalyCerebral cortical sizeGlial cellsCortical sizeUndifferentiated cell typesNeural progenitor cellsRadial gliaASPM proteinCerebral cortical expansionMicrocephaly genesDivergent functionsGenome editingSequence homologyDifferentiated progenitorsOuter subventricular zoneCortical expansionPrimary microcephalyCell typesGermline knockout
2014
Diffusion Tensor Imaging as a Predictor of Locomotor Function after Experimental Spinal Cord Injury and Recovery
Kelley BJ, Harel NY, Kim CY, Papademetris X, Coman D, Wang X, Hasan O, Kaufman A, Globinsky R, Staib LH, Cafferty WB, Hyder F, Strittmatter SM. Diffusion Tensor Imaging as a Predictor of Locomotor Function after Experimental Spinal Cord Injury and Recovery. Journal Of Neurotrauma 2014, 31: 1362-1373. PMID: 24779685, PMCID: PMC4120934, DOI: 10.1089/neu.2013.3238.Peer-Reviewed Original ResearchConceptsSpinal cord injuryDiffusion tensor imagingCord injuryAxonal integrityLocomotor functionExperimental spinal cord injuryTraumatic spinal cord injuryFemale Sprague-Dawley ratsTensor imagingFractional anisotropyFunctional recovery assessmentSpinal cord contusionLimited functional recoveryLong-term disabilityQuantitative diffusion tensor imagingRodent SCI modelsSprague-Dawley ratsSpinal cord morphologyWhite matter pathologyCaudal spinal cordWhite matter integrityInjury epicenterMidthoracic laminectomyCord contusionPrimary outcomeRadial Basis Functions for Combining Shape and Speckle Tracking in 4D Echocardiography
Compas C, Wong EY, Huang X, Sampath S, Lin BA, Pal P, Papademetris X, Thiele K, Dione DP, Stacy M, Staib LH, Sinusas AJ, O'Donnell M, Duncan JS. Radial Basis Functions for Combining Shape and Speckle Tracking in 4D Echocardiography. IEEE Transactions On Medical Imaging 2014, 33: 1275-1289. PMID: 24893257, PMCID: PMC4283552, DOI: 10.1109/tmi.2014.2308894.Peer-Reviewed Original Research
2013
Contour tracking in echocardiographic sequences via sparse representation and dictionary learning
Huang X, Dione DP, Compas CB, Papademetris X, Lin BA, Bregasi A, Sinusas AJ, Staib LH, Duncan JS. Contour tracking in echocardiographic sequences via sparse representation and dictionary learning. Medical Image Analysis 2013, 18: 253-271. PMID: 24292554, PMCID: PMC3946038, DOI: 10.1016/j.media.2013.10.012.Peer-Reviewed Original ResearchConceptsContour trackerSparse representationEchocardiographic sequencesRegion-based level set segmentationLevel set segmentationLocal image appearanceManual tracingExpert manual tracingsMultiscale sparse representationImage sequencesSegmentation resultsAppearance modelSpatiotemporal priorsFirst frameMultilevel informationHuman data setsEjection fraction estimatesLocal appearanceImage appearanceDictionary learningShape modelContour trackingManual resultsData setsContour estimation
2011
Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling
Sahul ZH, Mukherjee R, Song J, McAteer J, Stroud RE, Dione DP, Staib L, Papademetris X, Dobrucki LW, Duncan JS, Spinale FG, Sinusas AJ. Targeted Imaging of the Spatial and Temporal Variation of Matrix Metalloproteinase Activity in a Porcine Model of Postinfarct Remodeling. Circulation Cardiovascular Imaging 2011, 4: 381-391. PMID: 21505092, PMCID: PMC3140564, DOI: 10.1161/circimaging.110.961854.Peer-Reviewed Original ResearchVessel Connectivity Using Murray’s Hypothesis
Jiang Y, Zhuang ZW, Sinusas AJ, Staib LH, Papademetris X. Vessel Connectivity Using Murray’s Hypothesis. Lecture Notes In Computer Science 2011, 14: 528-536. PMID: 22003740, PMCID: PMC3367766, DOI: 10.1007/978-3-642-23626-6_65.Peer-Reviewed Original Research
2010
Refraction corrected transmission ultrasound computed tomography for application in breast imaging
Li S, Jackowski M, Dione DP, Varslot T, Staib LH, Mueller K. Refraction corrected transmission ultrasound computed tomography for application in breast imaging. Medical Physics 2010, 37: 2233-2246. PMID: 20527557, PMCID: PMC2874040, DOI: 10.1118/1.3360180.Peer-Reviewed Original Research
2009
DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy
Chahboune H, Mishra AM, DeSalvo MN, Staib LH, Purcaro M, Scheinost D, Papademetris X, Fyson SJ, Lorincz ML, Crunelli V, Hyder F, Blumenfeld H. DTI abnormalities in anterior corpus callosum of rats with spike–wave epilepsy. NeuroImage 2009, 47: 459-466. PMID: 19398019, PMCID: PMC2712639, DOI: 10.1016/j.neuroimage.2009.04.060.Peer-Reviewed Original ResearchConceptsSpike-wave dischargesDiffusion tensor imagingAnterior corpus callosumWAG/RijFractional anisotropyWhite matter pathwaysSeizure activityAbsence epilepsyCorpus callosumDTI abnormalitiesEpileptic WAG/Rij ratsWAG/Rij ratsGenetic Absence Epilepsy RatsCallosal fractional anisotropySomatosensory cortex regionSpike-wave epilepsyBilateral spike-wave dischargesCommon seizure disorderWistar albino Glaxo ratsGlaxo ratsChronic seizuresEpileptic animalsNonepileptic controlsSeizure disorderNeurological difficulties
2005
Characterizing Vascular Connectivity from microCT Images
Jackowski M, Papademetris X, Dobrucki LW, Sinusas AJ, Staib LH. Characterizing Vascular Connectivity from microCT Images. Lecture Notes In Computer Science 2005, 8: 701-708. PMID: 16686021, DOI: 10.1007/11566489_86.Peer-Reviewed Original ResearchArticulated Rigid Registration for Serial Lower-Limb Mouse Imaging
Papademetris X, Dione DP, Dobrucki LW, Staib LH, Sinusas AJ. Articulated Rigid Registration for Serial Lower-Limb Mouse Imaging. Lecture Notes In Computer Science 2005, 8: 919-926. PMID: 16686048, DOI: 10.1007/11566489_113.Peer-Reviewed Original ResearchRegional Whole Body Fat Quantification in Mice
Papademetris X, Shkarin P, Staib LH, Behar KL. Regional Whole Body Fat Quantification in Mice. Lecture Notes In Computer Science 2005, 19: 369-380. PMID: 17354710, DOI: 10.1007/11505730_31.Peer-Reviewed Original Research
2001
A new method for quantification of spatial and temporal parameters of endocardial motion: evaluation of experimental infarction using magnetic resonance imaging.
Heller EN, Staib LH, Dione DP, Constable RT, Shi CQ, Duncan JS, Sinusas AJ. A new method for quantification of spatial and temporal parameters of endocardial motion: evaluation of experimental infarction using magnetic resonance imaging. Canadian Journal Of Cardiology 2001, 17: 309-18. PMID: 11264564.Peer-Reviewed Original Research