2018
Cross-sensitivity of psychiatric and behavioral side effects with antiepileptic drug use
Chen B, Choi H, Hirsch LJ, Legge A, Buchsbaum R, Detyniecki K. Cross-sensitivity of psychiatric and behavioral side effects with antiepileptic drug use. Seizure 2018, 62: 38-42. PMID: 30273800, DOI: 10.1016/j.seizure.2018.09.014.Peer-Reviewed Original ResearchConceptsBehavioral side effectsMore antiepileptic drugsAntiepileptic drugsSide effectsAdult patientsSpecific antiepileptic drugsAntiepileptic drug useCertain antiepileptic drugsHistory of depressionAED usePatientsDrug useSignificant predictorsSignificant increasePsychosisDepressionZNSConfoundersEpilepsyDose
2017
Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy
Chen B, Choi H, Hirsch LJ, Katz A, Legge A, Buchsbaum R, Detyniecki K. Psychiatric and behavioral side effects of antiepileptic drugs in adults with epilepsy. Epilepsy & Behavior 2017, 76: 24-31. PMID: 28931473, DOI: 10.1016/j.yebeh.2017.08.039.Peer-Reviewed Original ResearchConceptsBehavioral side effectsSide effectsPractice-based sampleAntiepileptic drug useHigh rateAED regimenAdult patientsNewer AEDsCessation ratesAntiepileptic drugsIntractable epilepsyMedical historyAbsence seizuresMedical recordsPhysician reportsAED usePatientsLevetiracetamDepressive moodDrug useGabapentinLamotriginePatient recordsSuicidal thoughtsPhenytoin
2015
Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE)
Touloumes G, Morse E, Chen WC, Gober L, Dente J, Lilenbaum R, Katzenstein E, Pacelli A, Johnson E, Si Y, Sivaraju A, Grover E, Khozein R, Cunningham C, Hirsch LJ, Blumenfeld H. Human bedside evaluation versus automatic responsiveness testing in epilepsy (ARTiE). Epilepsia 2015, 57: e28-e32. PMID: 26663137, PMCID: PMC4707993, DOI: 10.1111/epi.13262.Peer-Reviewed Original ResearchConceptsVideo-EEG dataResponsiveness testingClinical careBehavioral testingInpatient video-electroencephalography (EEG) monitoringVideo-electroencephalography monitoringVideo-EEG monitoringAdditional clinical testingPediatric patientsEpilepsy centersPresurgical evaluationBedside evaluationClinical testingEpileptic seizuresBehavioral impairmentsSeizuresAccurate diagnosisNonmedical personnelPatient roomsEpilepsyBehavioral evaluationSeizure detectionBehavioral tasksMedical decisionsAutomatic seizure detection
2006
Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders
Malik S, Arif H, Hirsch LJ. Lamotrigine and its applications in the treatment of epilepsy and other neurological and psychiatric disorders. Expert Review Of Neurotherapeutics 2006, 6: 1609-1627. PMID: 17144777, DOI: 10.1586/14737175.6.11.1609.Peer-Reviewed Original ResearchConceptsBroad-spectrum antiepileptic drugBipolar disorder type ILennox-Gastaut syndromeTreatment of epilepsySerious skin rashesTreatment of womenFavorable pharmacokinetic propertiesConcomitant medicationsNeuropathic painElderly patientsSkin rashAdjunctive treatmentDose adjustmentGeneralized seizuresPartial seizuresAntiepileptic drugsSlow titrationNeurological conditionsPsychiatric disordersAdult populationLamotriginePharmacokinetic propertiesSmall riskPreliminary dataEpilepsy
2004
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy
Hirsch LJ, Weintraub D, Du Y, Buchsbaum R, Spencer HT, Hager M, Straka T, Bazil CW, Adams DJ, Resor SR, Morrell MJ. Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy. Neurology 2004, 63: 1022-1026. PMID: 15452293, DOI: 10.1212/01.wnl.0000138424.33979.0c.Peer-Reviewed Original ResearchMeSH KeywordsAnticonvulsantsDose-Response Relationship, DrugDrug EruptionsDrug InteractionsDrug Therapy, CombinationEpilepsyFemaleGastrointestinal DiseasesHeadacheHumansLamotrigineMaleMental DisordersNervous System DiseasesRetrospective StudiesSleep Initiation and Maintenance DisordersTriazinesValproic AcidConceptsLamotrigine serum concentrationsSpecific side effectsAntiepileptic drugsSide effectsSerum levelsLTG levelsSerum concentrationsColumbia Comprehensive Epilepsy CenterConcomitant antiepileptic drugsLTG serum levelsComprehensive Epilepsy CenterRates of toxicityDuration of useInitial target rangeAED regimensRefractory patientsToxic regimenConcurrent medicationsSeizure freedomAdditional efficacyClinical toxicityEpilepsy centersLTG concentrationsClinical trialsDose changes