2021
Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention
Cutillo G, Tolba H, Hirsch LJ. Anti-seizure medications and efficacy against focal to bilateral tonic-clonic seizures: A systematic review with relevance for SUDEP prevention. Epilepsy & Behavior 2021, 117: 107815. PMID: 33640562, DOI: 10.1016/j.yebeh.2021.107815.Peer-Reviewed Original ResearchConceptsAnti-seizure medicationsBilateral tonic-clonic seizuresTonic-clonic seizuresSUDEP preventionSystematic reviewPlacebo-controlled clinical trialFocal impaired awareness seizuresRisk of SUDEPSudden unexpected deathMajor risk factorAwareness seizuresRisk factorsClinical trialsUnexpected deathFBTCSHigh dosesSeizuresStrong associationSUDEPPreventionMedicationsTiagabineEfficacyLamotrigineBrivaracetam
2012
Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials
Tomson T, Hirsch LJ, Friedman D, Bester N, Hammer A, Irizarry M, Ishihara L, Krishen A, Spaulding T, Wamil A, Leadbetter R. Sudden unexpected death in epilepsy in lamotrigine randomized‐controlled trials. Epilepsia 2012, 54: 135-140. PMID: 23030403, DOI: 10.1111/j.1528-1167.2012.03689.x.Peer-Reviewed Original ResearchConceptsSudden unexpected deathProbable SUDEPTreatment armsAntiepileptic drugsClinical trialsOdds ratioUnexpected deathTonic-clonic seizure frequencyRate of SUDEPRisk of SUDEPRandomized clinical trialsRandomized-controlled trialPotential risk factorsCause deathPossible SUDEPStudy medicationPatient yearsSeizure frequencyTreatment deathsComparator armActive comparatorNonrandomized studyUnadjusted ratesComparator groupRisk factors
2011
Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print)
Hirsch LJ, Donner EJ, So EL, Jacobs M, Nashef L, Noebels JL, Buchhalter JR. Abbreviated report of the NIH/NINDS workshop on sudden unexpected death in epilepsy(e–Pub ahead of print). Neurology 2011, 76: 1932-1938. PMID: 21543734, PMCID: PMC3115809, DOI: 10.1212/wnl.0b013e31821de7de.Peer-Reviewed Original ResearchConceptsSudden infant death syndromeSudden unexpected deathSudden cardiac deathCardiac deathUnexpected deathAwareness of SUDEPPrevention of SUDEPRisk of SUDEPImproved seizure controlInfant death syndromeUnderstanding of SUDEPHealth care practitionersBasic science researchSUDEP incidenceDevastating complicationSeizure controlMulticenter collaborative researchSUDEPDeath syndromeAnimal modelsCare practitionersNeurological disordersEpilepsyPhysiologic featuresGenetic factors
2009
Breathing New Life into the Fight against Sudden Death in Epilepsy
Hirsch LJ. Breathing New Life into the Fight against Sudden Death in Epilepsy. Epilepsy Currents 2009, 9: 137-139. PMID: 19826505, PMCID: PMC2759044, DOI: 10.1111/j.1535-7511.2009.01319.x.Peer-Reviewed Original ResearchLocalization-related epilepsyOxygen desaturationIctal hypoxemiaSecondary generalizationSeizure durationGeneralized convulsionsSeizure localizationContralateral spreadSecondary generalized convulsionsEnd-tidal carbon dioxideIntractable localization-related epilepsyVideo-EEG telemetryMean oxygen saturationSudden unexpected deathBody mass indexOxygen saturation dataDegree of desaturationElectrographic evidenceSeizure spreadConsecutive patientsPartial seizuresMass indexSeizure lateralizationObstructive apnoeaMean duration