Kyung-Heup Ahn, MD
Assistant Professor of PsychiatryCards
About
Research
Publications
2015
Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine
Ahn KH, Sewell A, Elander J, Pittman B, Ranganathan M, Gunduz-Bruce H, Krystal J, D'Souza DC. Role of GABA Deficit in Sensitivity to the Psychotomimetic Effects of Amphetamine. Neuropsychopharmacology 2015, 40: 2822-2831. PMID: 25953357, PMCID: PMC4864658, DOI: 10.1038/npp.2015.132.Peer-Reviewed Original ResearchConceptsGABA deficitHealthy subjectsPsychotomimetic effectsIntravenous infusionSchizophrenia patientsPANSS positive symptoms subscaleDouble-blind crossover designStriatal dopamine releasePositive symptom subscaleAdministration of drugsDose of AMPHPartial inverse agonistSubclinical responsePharmacokinetic interactionsSubthreshold doseDopamine releaseBenzodiazepine receptorsSymptom subscalesCrossover designCADSS scoresPositive symptomsAMPHInverse agonistSubjective effectsTest day
2012
Nicotine Fails to Attenuate Ketamine-Induced Cognitive Deficits and Negative and Positive Symptoms in Humans: Implications for Schizophrenia
D'Souza DC, Ahn K, Bhakta S, Elander J, Singh N, Nadim H, Jatlow P, Suckow RF, Pittman B, Ranganathan M. Nicotine Fails to Attenuate Ketamine-Induced Cognitive Deficits and Negative and Positive Symptoms in Humans: Implications for Schizophrenia. Biological Psychiatry 2012, 72: 785-794. PMID: 22717030, DOI: 10.1016/j.biopsych.2012.05.009.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAttentionCognitionCognition DisordersCross-Over StudiesDouble-Blind MethodDrug InteractionsExecutive FunctionHumansInhibition, PsychologicalKetamineMemoryMiddle AgedMotor SkillsNicotinePsychiatric Status Rating ScalesPsychomotor PerformanceReaction TimeRecognition, PsychologySchizophreniaConceptsCognitive deficitsPositive symptomsExecutive functionResponse inhibitionKetamine-induced cognitive deficitsChoice reaction time taskSpeed of processingReaction time taskReaction timeVisual memoryEmotion recognitionImmediate recallSustained attentionTime taskFeeling statesPerceptual alterationsSerial processingEffects of nicotineNegative symptomsMemoryBehavioral effectsDeficitsInteractive effectsNicotine infusionTest day
2010
Probing GABA Receptor Function in Schizophrenia with Iomazenil
Ahn K, Gil R, Seibyl J, Sewell RA, D'Souza DC. Probing GABA Receptor Function in Schizophrenia with Iomazenil. Neuropsychopharmacology 2010, 36: 677-683. PMID: 21068719, PMCID: PMC3055690, DOI: 10.1038/npp.2010.198.Peer-Reviewed Original ResearchConceptsSchizophrenia patientsHealthy controlsGABA deficitHealthy subjectsBrief Psychiatric Rating ScaleGABA-deficit hypothesisPlacebo-controlled studyChronic schizophrenia patientsPathophysiology of schizophreniaPsychiatric Rating ScalePartial inverse agonistDissociative Symptoms ScaleGABA receptor functionPerceptual alterationsPsychotomimetic effectsPsychotic symptomsIomazenilBenzodiazepine receptorsPatientsSymptom ScalePharmacological inductionReceptor functionInverse agonistRating ScaleBrain imaging
2004
White matter hyperintensities in subjects with bipolar disorder
AHN KH, LYOO IK, LEE HK, SONG IC, OH JS, HWANG J, KWON J, KIM MJ, KIM M, RENSHAW PF. White matter hyperintensities in subjects with bipolar disorder. Psychiatry And Clinical Neurosciences 2004, 58: 516-521. PMID: 15482583, DOI: 10.1111/j.1440-1819.2004.01294.x.Peer-Reviewed Original ResearchConceptsWhite matter hyperintensitiesBipolar disorderMatter hyperintensitiesComparison subjectsSubcortical white matter hyperintensitiesSeverity of WMHSevere white matter hyperintensitiesDeep white matter hyperintensitiesRating ScaleStructured Clinical InterviewStatistical Manual IVHealthy comparison subjectsInversion recovery imagesHigh prevalenceBipolar patientsBipolar subjectsGreater prevalenceClinical InterviewMagnetic resonance imagesMagnetic resonance scannerPrevalenceRecovery imagesDivergent reportsDisordersBrain magnetic resonance images
2003
N-Methyl-d-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory process
Ahn KH, Youn T, Cho SS, Ha TH, Ha KS, Kim MS, Kwon JS. N-Methyl-d-aspartate receptor in working memory impairments in schizophrenia: event-related potential study of late stage of working memory process. Progress In Neuro-Psychopharmacology And Biological Psychiatry 2003, 27: 993-999. PMID: 14499316, DOI: 10.1016/s0278-5846(03)00159-3.Peer-Reviewed Original Research
Clinical Trials
Current Trials
M1 Schizophrenia PET Study
HIC ID2000031171RoleSub InvestigatorPrimary Completion Date04/30/2023Recruiting ParticipantsGenderBothAge18 years - 55 years