Srikrishna Dasari
he/him/his
Postgraduate AssociateAbout
Research
Publications
2022
APOBEC mutagenesis and selection for NFE2L2 contribute to the origin of lung squamous-cell carcinoma
Cannataro VL, Kudalkar S, Dasari K, Gaffney SG, Lazowski HM, Jackson LK, Yildiz I, Das RK, Rothberg BE, Anderson KS, Townsend JP. APOBEC mutagenesis and selection for NFE2L2 contribute to the origin of lung squamous-cell carcinoma. Lung Cancer 2022, 171: 34-41. PMID: 35872531, PMCID: PMC10126952, DOI: 10.1016/j.lungcan.2022.07.004.Peer-Reviewed Original ResearchConceptsCytidine deaminationMutagenic processesDefective homologous recombinationGenomic sequencesHomologous recombinationAttractive potential targetAPOBEC mutagenesisLung squamous cell carcinomaDeamination activityCancer cell growthAPOBEC proteinsAPOBEC activityCell growthCellular proliferationNFE2L2MutationsMolecular investigationsCancer effectsPotential targetMolecular variantsAPOBECSurvival of cancerSquamous cell carcinomaDeaminationVariants
2021
Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors—on average—to exhibit a lower mutation burden
Tan C, Mandell JD, Dasari K, Cannataro VL, Alfaro-Murillo JA, Townsend JP. Heavy mutagenesis by tobacco leads to lung adenocarcinoma tumors with KRAS G12 mutations other than G12D, leading KRAS G12D tumors—on average—to exhibit a lower mutation burden. Lung Cancer 2021, 166: 265-269. PMID: 34736794, DOI: 10.1016/j.lungcan.2021.10.008.Peer-Reviewed Original ResearchThe somatic molecular evolution of cancer: Mutation, selection, and epistasis
Dasari K, Somarelli JA, Kumar S, Townsend JP. The somatic molecular evolution of cancer: Mutation, selection, and epistasis. Progress In Biophysics And Molecular Biology 2021, 165: 56-65. PMID: 34364910, PMCID: PMC8819680, DOI: 10.1016/j.pbiomolbio.2021.08.003.Peer-Reviewed Original ResearchConceptsCancer evolutionEpistatic interactionsNeutral mutation rateCancer progressionEvolution of neoplasmsSingle nucleotide variantsMolecular evolutionRate of fixationGenetic interactionsEvolutionary biologyPhylogenetic analysisCopy number aberrationsPhylogenetic relationsNeutral mutationsGenomic dataSelective pressureSynonymous mutationsMutation rateChromosomal instabilityPhenotypic changesLoss of heterozygosityFitness landscapeClonal deconvolutionTumor microenvironmentEnvironment interaction
2020
Role of diversity-generating retroelements for regulatory pathway tuning in cyanobacteria
Vallota-Eastman A, Arrington E, Meeken S, Roux S, Dasari K, Rosen S, Miller J, Valentine D, Paul B. Role of diversity-generating retroelements for regulatory pathway tuning in cyanobacteria. BMC Genomics 2020, 21: 664. PMID: 32977771, PMCID: PMC7517822, DOI: 10.1186/s12864-020-07052-5.Peer-Reviewed Original ResearchConceptsDiversity-generating retroelementsFilamentous strains of cyanobacteriaEnvironmental stressCore cellular processesUnique domain architectureStrains of cyanobacteriaCell-cell attachmentLigand-binding moduleSignal responseCyanobacterial genomesMonophyletic cladeArchaeal lineagesIntragenomic duplicationsLigand-binding domainDomain architectureCyanobacterial generaFilamentous strainsRegulatory networksFilamentous cyanobacteriaRegulatory genesHypervariable proteinsCellular processesRetroelementsCyanobacteriaRegulatory pathways