Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice
Schukken K, Zhu Y, Bakker P, Koster M, Harkema L, Youssef S, de Bruin A, Foijer F. Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice. Scientific Reports 2021, 11: 68. PMID: 33420244, PMCID: PMC7794249, DOI: 10.1038/s41598-020-80169-5.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtrophyIntestinesM Phase Cell Cycle CheckpointsMad2 ProteinsMiceMice, Inbred C57BLMice, KnockoutConceptsAdult miceChromosomal instabilitySpindle assembly checkpointSevere intestinal phenotypeSubstantial weight lossEmbryonic lethalityLow proliferation rateP53 inactivationVillous atrophyMouse modelAneuploid cellsIntestinal phenotypeTumor evolutionIntestinal epitheliaIntestinal atrophyTissue-specific fashionMiceProliferation rateWeight lossSpindle assembly checkpoint functionAtrophyEpitheliaAssembly checkpointTissueLethality