Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice
Schukken K, Zhu Y, Bakker P, Koster M, Harkema L, Youssef S, de Bruin A, Foijer F. Acute systemic loss of Mad2 leads to intestinal atrophy in adult mice. Scientific Reports 2021, 11: 68. PMID: 33420244, PMCID: PMC7794249, DOI: 10.1038/s41598-020-80169-5.Peer-Reviewed Original ResearchConceptsAdult miceChromosomal instabilitySpindle assembly checkpointSevere intestinal phenotypeSubstantial weight lossEmbryonic lethalityLow proliferation rateP53 inactivationVillous atrophyMouse modelAneuploid cellsIntestinal phenotypeTumor evolutionIntestinal epitheliaIntestinal atrophyTissue-specific fashionMiceProliferation rateWeight lossSpindle assembly checkpoint functionAtrophyEpitheliaAssembly checkpointTissueLethality