Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
Schukken K, Lin Y, Bakker P, Schubert M, Preuss S, Simon J, van den Bos H, Storchova Z, Colomé-Tatché M, Bastians H, Spierings D, Foijer F. Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition. Life Science Alliance 2020, 3: e201900499. PMID: 31980556, PMCID: PMC6985455, DOI: 10.26508/lsa.201900499.Peer-Reviewed Original ResearchMeSH KeywordsAneuploidyAniline CompoundsBenzimidazolesChromosomal InstabilityDrug SynergismGene Knockdown TechniquesHT29 CellsHumansKineticsM Phase Cell Cycle CheckpointsMCF-7 CellsMicrotubulesNeoplasmsNitrilesPhenotypePolymerizationProtein Kinase InhibitorsQuinolinesSpindle ApparatusSrc-Family KinasesConceptsChromosomal instability phenotypeChromosomal instabilitySpindle assembly checkpointDefective spindle assembly checkpointMicrotubule polymerization ratesHallmarks of cancerSensitivity to microtubule poisonsSmall-molecule compound screeningTargeting aneuploidyCheckpoint inhibitionPolymerization rateSAC inhibitionEuploid counterpartsTreated tumorsMicrotubule dynamicsAneuploid cellsTarget cellsCancerTumorAneuploidyMicrotubule poisonsToxic to cellsCells