2024
Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention
Callegari S, Romain G, Cleman J, Scierka L, Jacque F, Smolderen K, Mena‐Hurtado C. Long‐Term Mortality Predictors Using a Machine‐Learning Approach in Patients With Chronic Limb‐Threatening Ischemia After Peripheral Vascular Intervention. Journal Of The American Heart Association 2024, 13: e034477. PMID: 38761075, PMCID: PMC11179837, DOI: 10.1161/jaha.124.034477.Peer-Reviewed Original ResearchConceptsChronic limb-threatening ischemiaPeripheral vascular interventionsHealth careLimb-threatening ischemiaMortality predictorsLong-term mortality riskMultidimensional risk factorsBody mass indexLong-term mortality predictorsImprove individualized careVascular interventionsIndividualized careAssisted careBiopsychosocial modelMortality riskCareMass indexRisk factorsMedical comorbiditiesRisk profileInterventionMortality rateChronic kidney diseaseMortalityPredictive variablesVariability in short-term mortality following repair of ruptured abdominal aortic aneurysms across centers and physicians
Romain G, Wang K, Scierka L, Cleman J, Callegari S, Aboian E, Smolderen K, Mena-Hurtado C. Variability in short-term mortality following repair of ruptured abdominal aortic aneurysms across centers and physicians. Journal Of Vascular Surgery 2024, 80: 737-745.e14. PMID: 38729585, DOI: 10.1016/j.jvs.2024.05.004.Peer-Reviewed Original ResearchPhysician variablesPhysician volumeRuptured infrarenal abdominal aortic aneurysmMortality riskPhysician levelAbdominal aortic aneurysmShort-term mortalityProcedure volumeMortality outcomesQuality of careAortic aneurysmMedian odds ratioShort-term mortality outcomesRepair of ruptured abdominal aortic aneurysmMedicare claims dataInfrarenal abdominal aortic aneurysmRuptured abdominal aortic aneurysmVascular Quality Initiative databaseAssociated with short-term mortalityLogistic regression modelsMortality rateCenter-level factorsCare managementClaims dataOdds ratioComparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease
Cleman J, Sierra J, Romain G, Capuano B, Scierka L, Callegari S, Jacque F, Peri-Okonny P, Nagpal S, Smolderen K, Mena-Hurtado C. Comparison of mortality and amputation after lower extremity bypass versus peripheral vascular intervention in patients with chronic limb-threatening ischemia and comorbid chronic kidney disease. Journal Of Vascular Surgery 2024, 80: 480-489.e5. PMID: 38608966, DOI: 10.1016/j.jvs.2024.04.016.Peer-Reviewed Original ResearchChronic limb-threatening ischemiaAll-cause mortalityLower extremity bypassPeripheral vascular interventionsComorbid chronic kidney diseaseLimb-threatening ischemiaComparison of mortalityPreference-sensitive treatment decisionsCox proportional hazards modelsRisk of deathInteraction termsProportional hazards modelLower-extremity bypassChronic kidney diseaseFine-Gray modelMortality riskVascular interventionsAmputationHazards modelOutcome dataFine-GrayAssociated with worse outcomesHigh riskKidney diseasePropensity score
2023
Drug‐Coated Balloon and Drug‐Eluting Stent Safety in Patients With Femoropopliteal and Severe Chronic Kidney Disease
Hanna J, Smolderen K, Castro‐Dominguez Y, Romain G, Lee M, Turner J, Mena‐Hurtado C. Drug‐Coated Balloon and Drug‐Eluting Stent Safety in Patients With Femoropopliteal and Severe Chronic Kidney Disease. Journal Of The American Heart Association 2023, 12: e028622. PMID: 36974774, PMCID: PMC10122876, DOI: 10.1161/jaha.122.028622.Peer-Reviewed Original ResearchConceptsEarly-stage chronic kidney diseaseChronic kidney diseaseBare metal stentsDrug-eluting stentsDrug-coated balloonsMortality riskAmputation riskKidney diseaseSevere chronic kidney diseaseMajor amputation riskPlain balloon angioplastyDrug-Coated BalloonAmputation outcomesCKD statusAmputation rateCause mortalityBackground PatientsAdjusted analysisBalloon angioplastyFemoropopliteal interventionsDES useBMS useRegistry dataDisease trialsPatientsGuideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions
Smolderen K, Romain G, Provance J, Scierka L, Mao J, Goodney P, Henke P, Sedrakyan A, Mena-Hurtado C. Guideline-Directed Medical Therapy and Long-Term Mortality and Amputation Outcomes in Patients Undergoing Peripheral Vascular Interventions. JACC Cardiovascular Interventions 2023, 16: 332-343. PMID: 36792257, PMCID: PMC10359106, DOI: 10.1016/j.jcin.2022.09.022.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyPeripheral vascular interventionsMedical therapyVascular interventionsEnzyme inhibitors/angiotensin receptor blockersVascular Quality Initiative registryAngiotensin receptor blockersLong-term mortalityRisk of amputationRisk of mortalityNational quality registryQuality improvement effortsAmputation outcomesAmputation riskMajor amputationAntiplatelet therapyCause mortalityReceptor blockersMean ageVascular careQuality registryObservational studyMortality riskHigh riskAmputation data
2022
Association of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease
Tran AT, Spertus JA, Mena‐Hurtado C, Jones PG, Aronow HD, Safley DM, Malik AO, Peri‐Okonny P, Shishehbor MH, Labrosciano C, Smolderen KG. Association of Disease‐Specific Health Status With Long‐Term Survival in Peripheral Artery Disease. Journal Of The American Heart Association 2022, 11: e022232. PMID: 35132874, PMCID: PMC9245831, DOI: 10.1161/jaha.121.022232.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePAD-specific health statusHealth statusPAD symptomsArtery diseaseHierarchical Cox regression modelsDisease-specific health statusLong-term mortality riskTime of diagnosisCox regression modelLong-term survivalPORTRAIT registryCardiovascular morbidityCause mortalityResults PatientsKaplan-MeierMortality riskUnadjusted modelsSummary scoresUS sitesPatientsMortalityBaselineSymptomsDisease
2016
Clinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction
Shore S, Smolderen KG, Spertus JA, Kennedy KF, Jones PG, Zhao Z, Wang TY, Arnold SV. Clinical Relevance of Rehospitalizations for Unstable Angina and Unplanned Revascularization Following Acute Myocardial Infarction. Journal Of The American Heart Association 2016, 5: e003129. PMID: 27543798, PMCID: PMC5015270, DOI: 10.1161/jaha.115.003129.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionUnplanned revascularizationUnstable anginaMyocardial infarctionSubsequent rehospitalizationClinical relevanceAcute Myocardial Infarction RegistryProportional hazard Cox regressionUnplanned coronary revascularizationComposite end pointMyocardial Infarction RegistryRehospitalization groupCause mortalityCoronary revascularizationRevascularization groupRehospitalization ratesPropensity matchingCox regressionMean ageClinical trialsRehospitalizationRevascularizationMortality riskHigh riskPatients