2023
In-home Visits and Subsequent Health Outcomes in Medicare Advantage Beneficiaries With Coronary Artery Disease, Diabetes, Hypertension, and Depression
Smolderen K, Heath K, Ameli O, Spencer D, Natwick T, Musich S, Miedico T, Mena-Hurtado C. In-home Visits and Subsequent Health Outcomes in Medicare Advantage Beneficiaries With Coronary Artery Disease, Diabetes, Hypertension, and Depression. Medical Care 2023, 61: 366-376. PMID: 37167558, DOI: 10.1097/mlr.0000000000001850.Peer-Reviewed Original ResearchConceptsPrimary care visitsCoronary artery diseaseMajor adverse cardiovascular eventsFirst primary care visitAdverse cardiovascular eventsCare visitsWait-list control groupHome visitsArtery diseaseList control groupControl groupCardiovascular eventsCare metricsOptum Labs Data WarehouseHigh-morbidity conditionsMedicare Advantage populationInpatient care episodesMedicare Advantage beneficiariesRetrospective data analysisSubsequent health outcomesIndex dateSecondary outcomesEmergency visitsPrimary outcomeInpatient stay
2022
Health status and cognitive function for risk stratification in chronic coronary and peripheral artery disease.
Smolderen K, Mena-Hurtado C, Eikelboom J, Bosch J, Xie F, Ramasundarahettige C, Bhatt D, Anand S. Health status and cognitive function for risk stratification in chronic coronary and peripheral artery disease. European Journal Of Preventive Cardiology 2022, 30: 535-545. PMID: 36444513, DOI: 10.1093/eurjpc/zwac282.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseDigit Symbol Substitution TestVisual analog scaleEQ visual analogue scaleHealth statusLimb eventsCAD cohortCognitive functionArtery diseaseEQ-5DHierarchical Cox regression modelsMajor adverse cardiovascular eventsStable coronary artery diseaseAdverse cardiovascular eventsPeripheral artery diseasePopulation attributable riskCox regression modelOverall health statusCognitive function assessmentCOMPASS trialPAD cohortCardiovascular eventsPAD patientsRisk stratificationAnalog scaleThe association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis
Scierka LE, Mena-Hurtado C, Ahmed ZV, Yousef S, Arham A, Grimshaw AA, Harris KM, Burg M, Vriens PW, Heyligers J, Lee M, Yazgan I, Smolderen KG. The association of depression with mortality and major adverse limb event outcomes in patients with peripheral artery disease: A systematic review and meta-analysis. Journal Of Affective Disorders 2022, 320: 169-177. PMID: 36179780, DOI: 10.1016/j.jad.2022.09.098.Peer-Reviewed Original ResearchConceptsMajor adverse limb eventsPeripheral artery diseaseAssociation of depressionCause mortalityArtery diseaseDepressive symptomsSystematic reviewAdverse limb eventsAdverse prognostic outcomeCoronary artery diseaseRisk of biasImportant comorbidityPoor outcomeAdverse outcomesPrognostic outcomesPooled resultsRisk factorsObservational studyTreatment statusLimb eventsDepression severityPatientsLarger sample sizeMortalityRisk estimates
2017
Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry
Sawano M, Kohsaka S, Abe T, Inohara T, Maekawa Y, Ueda I, Sueyoshi K, Suzuki M, Noma S, Numasawa Y, Miyata H, Fukuda K, Smolderen KG, Spertus JA. Patterns of statin non-prescription in patients with established coronary artery disease: A report from a contemporary multicenter Japanese PCI registry. PLOS ONE 2017, 12: e0182687. PMID: 28817616, PMCID: PMC5560610, DOI: 10.1371/journal.pone.0182687.Peer-Reviewed Original ResearchConceptsChronic kidney diseaseCoronary artery diseasePCI patientsStatin therapyArtery diseaseKidney diseaseHierarchical multivariable logistic regression analysisMultivariable logistic regression analysisPercutaneous coronary intervention registryJapanese PCI registryStatin prescription patternsCoronary Intervention RegistryLow-intensity statinsLogistic regression analysisCardiovascular eventsPCI registryIntervention RegistryPatient characteristicsPrescription patternsReal-world practiceStudy registryEffective medicationsHigh riskPatientsHigher age
2015
Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control
2014
Peripheral arterial disease, gender, and depression in the Heart and Soul Study
Grenon SM, Cohen BE, Smolderen K, Vittinghoff E, Whooley MA, Hiramoto J. Peripheral arterial disease, gender, and depression in the Heart and Soul Study. Journal Of Vascular Surgery 2014, 60: 396-403. PMID: 24661811, PMCID: PMC4199228, DOI: 10.1016/j.jvs.2014.02.013.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseRisk factorsArterial diseaseDevelopment of PADStable coronary artery diseaseGender-specific risk factorsNontraditional risk factorsProspective cohort studyWorse lipid profileHistory of smokingTraditional risk factorsCoronary artery diseaseStrongest independent factorRole of depressionLogistic regression modelsSoul StudyCohort studyInflammatory biomarkersArtery diseaseDiabetes mellitusElevated fibrinogenSimilar prevalenceLipid profileHigh prevalenceIndependent factors
2013
Treatment Differences by Health Insurance Among Outpatients With Coronary Artery Disease Insights From the National Cardiovascular Data Registry
Smolderen KG, Spertus JA, Tang F, Oetgen W, Borden WB, Ting HH, Chan PS. Treatment Differences by Health Insurance Among Outpatients With Coronary Artery Disease Insights From the National Cardiovascular Data Registry. Journal Of The American College Of Cardiology 2013, 61: 1069-1075. PMID: 23375933, PMCID: PMC3641586, DOI: 10.1016/j.jacc.2012.11.058.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAmbulatory CareAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCoronary Artery DiseaseDrug UtilizationFemaleHumansHypolipidemic AgentsInsurance, HealthMaleMedicaidMedically UninsuredMedicareMiddle AgedPlatelet Aggregation InhibitorsRegistriesUnited StatesUnited States Department of Veterans AffairsUnited States Indian Health ServiceConceptsCoronary artery diseaseUninsured patientsEvidence-based treatmentsInsurance statusARB therapyAngiotensin-converting enzyme inhibitors/angiotensin II receptor blockersEnzyme inhibitors/angiotensin II receptor blockersAngiotensin II receptor blockersNational Cardiovascular Data RegistryPublic insuranceEvidence-based medicationsLipid-lowering therapyII receptor blockersLeft ventricular dysfunctionHealth insuranceTreatment differencesPoisson regression modelsPINNACLE RegistryPhysician adherenceVentricular dysfunctionReceptor blockersArtery diseaseCardiac RegistryCardiac outpatientsData registry
2012
Association Between Depression and Peripheral Artery Disease: Insights From the Heart and Soul Study
Grenon SM, Hiramoto J, Smolderen KG, Vittinghoff E, Whooley MA, Cohen BE. Association Between Depression and Peripheral Artery Disease: Insights From the Heart and Soul Study. Journal Of The American Heart Association 2012, 1: e002667. PMID: 23130170, PMCID: PMC3487348, DOI: 10.1161/jaha.112.002667.Peer-Reviewed Original ResearchPrevalent peripheral artery diseasePeripheral artery diseaseCoronary artery diseaseArtery diseasePAD eventsDepressive symptomsSoul StudyRisk factorsCox proportional hazards modelIncident PAD eventsModifiable risk factorsCongestive heart failureAssociation of depressionPatient Health QuestionnaireProportional hazards modelHigh-density lipoproteinRace/ethnicityAggressive treatmentProspective cohortSerum creatinineHeart failureTriglyceride levelsExcess riskIndependent associationMedical records
2011
Two-year Vascular Hospitalisation Rates and Associated Costs in Patients at Risk of Atherothrombosis in France and Germany: Highest Burden for Peripheral Arterial Disease
Smolderen KG, Wang K, de Pouvourville G, Brüggenjürgen B, Röther J, Zeymer U, Parhofer KG, Steg PG, Bhatt DL, Magnuson EA, Investigators R. Two-year Vascular Hospitalisation Rates and Associated Costs in Patients at Risk of Atherothrombosis in France and Germany: Highest Burden for Peripheral Arterial Disease. European Journal Of Vascular And Endovascular Surgery 2011, 43: 198-207. PMID: 22001145, DOI: 10.1016/j.ejvs.2011.09.016.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseCoronary artery diseaseHospitalisation ratesCerebrovascular diseaseArterial diseaseMultiple risk factorsRisk of atherothrombosisMRF groupPAD subgroupsREACH RegistryCardiovascular eventsPeripheral revascularizationArtery diseaseHospitalisation costsAtherothrombotic diseasePeripheral proceduresRisk factorsRisk groupsHigh burdenEconomic burdenPatientsDiseaseAtherothrombosisEvaluated groupAssociated costsReal-World Lessons From the Implementation of a Depression Screening Protocol in Acute Myocardial Infarction Patients
Smolderen KG, Buchanan DM, Amin AA, Gosch K, Nugent K, Riggs L, Seavey G, Spertus JA. Real-World Lessons From the Implementation of a Depression Screening Protocol in Acute Myocardial Infarction Patients. Circulation Cardiovascular Quality And Outcomes 2011, 4: 283-292. PMID: 21505152, PMCID: PMC3336360, DOI: 10.1161/circoutcomes.110.960013.Peer-Reviewed Original ResearchConceptsDepression screening protocolAcute myocardial infarction patientsPatient Health QuestionnaireMyocardial infarction patientsScreening protocolInfarction patientsPHQ-9AHA recommendationsAcute Myocardial Infarction RegistryAmerican Heart Association statementMyocardial Infarction RegistryCoronary artery diseaseAcute myocardial infarctionQuality improvement initiativesFull PHQ-9Implementation feedbackAHA statementCoronary patientsArtery diseaseMyocardial infarctionPHQ-2Provider suggestionsHealth QuestionnaireRegistry dataScreening program
2010
One-year costs associated with cardiovascular disease in Canada: Insights from the REduction of Atherothrombosis for Continued Health (REACH) registry
Smolderen KG, Bell A, Lei Y, Cohen EA, Steg PG, Bhatt DL, Mahoney EM, investigators O. One-year costs associated with cardiovascular disease in Canada: Insights from the REduction of Atherothrombosis for Continued Health (REACH) registry. Canadian Journal Of Cardiology 2010, 26: e297-e305. PMID: 20931098, PMCID: PMC2954538, DOI: 10.1016/s0828-282x(10)70437-2.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseContinued Health (REACH) RegistryReduction of AtherothrombosisCardiovascular risk factorsCoronary artery diseaseArterial bedMedication useHospitalization costsAtherothrombotic diseaseArtery diseaseMedication costsCerebrovascular diseaseHealth registriesRisk factorsEconomic burdenMore cardiovascular risk factorsAnnual hospitalization costsCardiovascular-related hospitalizationsMean hospitalization costOne-year followOne-year costsCardiovascular eventsPolyvascular diseaseAnnual hospitalizationsClinical factors
2008
Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors
Smolderen KG, Aquarius AE, de Vries J, Smith OR, Hamming JF, Denollet J. Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors. Journal Of Affective Disorders 2008, 110: 27-35. PMID: 18237784, DOI: 10.1016/j.jad.2007.12.238.Peer-Reviewed Original ResearchConceptsAnkle-brachial indexPeripheral arterial diseaseDepressive symptomsPAD patientsArterial diseaseRisk factorsDepressed patientsSymptomatic lower extremity peripheral arterial diseaseLower extremity peripheral arterial diseaseEpidemiological Studies Depression ScaleTreadmill walking distanceCardiovascular risk factorsCoronary artery diseasePsychotropic medication useRelevant depressive symptomsOnly baseline dataPAD severityArtery diseaseMedication usePatient groupPoor prognosisClinical correlatesDepression ScaleClinical careWalking distance