2023
Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults
Lee M, Smolderen K, Ionescu C, Hillegass W, Romain G, Mena-Hurtado C. Lower extremity symptoms and ankle–brachial index screening as predictors of cardiovascular outcomes in Black adults. Vascular Medicine 2023, 28: 197-204. PMID: 37293738, DOI: 10.1177/1358863x231151729.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAbnormal ABILower extremity symptomsNormal ABILeg symptomsHigh riskBlack adultsExtremity symptomsStepwise Cox proportional hazards modelKaplan-Meier survival curvesCox proportional hazards modelAnkle-brachial indexFramingham risk factorsJackson Heart StudyProportional hazards modelCardiovascular outcomesCause mortalityArtery diseaseAsymptomatic diseaseAdverse outcomesMean ageSymptom assessmentAsymptomatic participantsRisk factorsSymptomatic participants
2022
Ankle- and Toe-Brachial Index for Peripheral Artery Disease Identification: Unlocking Clinical Data Through Novel Methods
Friberg JE, Qazi AH, Boyle B, Franciscus C, Vaughan-Sarrazin M, Westerman D, Patterson OV, Parr SK, Matheny ME, Arya S, Smolderen KG, Lund BC, Gobbel GT, Girotra S. Ankle- and Toe-Brachial Index for Peripheral Artery Disease Identification: Unlocking Clinical Data Through Novel Methods. Circulation Cardiovascular Interventions 2022, 15: e011092. PMID: 35176872, PMCID: PMC10807980, DOI: 10.1161/circinterventions.121.011092.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseAnkle-brachial indexToe-brachial indexElectronic health recordsABI testingVeterans Affairs electronic health recordsHealth recordsStructured chart reviewVeterans Affairs facilitiesPositive predictive valuePAD patientsChart reviewArtery diseaseClinical dataClinical impactHigh prevalenceBilling codesSeparate cohortPredictive valuePatientsClinical expertsPAD researchRandom sampleLateralityReport
2021
Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study
Jelani QU, Mena-Hurtado C, Gosch K, Mohammed M, Labrosciano C, Regan C, Scierka LE, Spertus JA, Nagpal S, Smolderen KG. Association of sleep apnea with outcomes in peripheral artery disease: Insights from the PORTRAIT study. PLOS ONE 2021, 16: e0256933. PMID: 34506511, PMCID: PMC8432750, DOI: 10.1371/journal.pone.0256933.Peer-Reviewed Original ResearchConceptsPeripheral artery diseasePeripheral Artery QuestionnaireSleep apneaHealth statusArtery diseaseSummary scoresDisease-specific Peripheral Artery QuestionnaireFive-year survival curvesHigh ankle-brachial indexPAQ summary scoreVascular specialty clinicsAnkle-brachial indexLog-rank testSleep apnea statusHealth status outcomesWorse health statusQuality of lifeBetter health statusCause mortalityMultivariable adjustmentPAD symptomsCoronary diseasePeripheral interventionsUS patientsMean age
2020
Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial
Rymer JA, Mulder H, Smolderen KG, Hiatt WR, Conte MS, Berger JS, Norgren L, Mahaffey KW, Baumgartner I, Fowkes FG, Katona BG, Rockhold F, Jones WS, Patel MR. Association of Health Status Scores With Cardiovascular and Limb Outcomes in Patients With Symptomatic Peripheral Artery Disease: Insights From the EUCLID (Examining Use of Ticagrelor in Symptomatic Peripheral Artery Disease) Trial. Journal Of The American Heart Association 2020, 9: e016573. PMID: 32924754, PMCID: PMC7792388, DOI: 10.1161/jaha.120.016573.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesDouble-Blind MethodFemaleHealth Status IndicatorsHumansLower ExtremityMaleMiddle AgedOutcome Assessment, Health CarePeripheral Arterial DiseasePlatelet Aggregation InhibitorsQuality of LifeSurveys and QuestionnairesSymptom AssessmentTicagrelorVascular Surgical ProceduresVisual Analog ScaleConceptsMajor adverse cardiovascular eventsMajor adverse limb eventsAdverse cardiovascular eventsAdverse limb eventsLower extremity revascularizationPeripheral artery diseaseCardiovascular eventsHealth status instrumentsLimb eventsEUCLID trialVAS scoresArtery diseaseEQ-5DQuestionnaire scoresSubsequent major adverse cardiovascular eventsLow ankle-brachial indexSymptomatic peripheral artery diseaseLower extremity revascularization proceduresBaseline EQ-5DAnkle-brachial indexHealth status scoresEQ-5D scoresHealth status measurementHealth status changesSubsequent end pointsLevel of disease and association with health status in patients presenting with claudication from the PORTRAIT registry
Vogel TR, Braet DJ, Kruse RL, Bath J, Wang J, Gosch K, Smolderen KG. Level of disease and association with health status in patients presenting with claudication from the PORTRAIT registry. Journal Of Vascular Surgery 2020, 72: 2017-2026. PMID: 32325227, DOI: 10.1016/j.jvs.2020.03.042.Peer-Reviewed Original ResearchMeSH KeywordsAgedFemaleFunctional StatusHealth Status IndicatorsHumansIntermittent ClaudicationMaleMiddle AgedPatient SatisfactionPeripheral Arterial DiseasePredictive Value of TestsQuality of LifeRegistriesRetrospective StudiesSeverity of Illness IndexSurveys and QuestionnairesTime FactorsTreatment OutcomeConceptsPeripheral artery diseasePAQ summary scorePeripheral Artery QuestionnaireQuality of lifeAnkle-brachial indexMultilevel diseaseAortoiliac diseaseHealth statusAnatomic levelSummary scoresMedical managementHigh ankle-brachial indexFemoral-popliteal diseaseTreatment of aortoiliacChronic kidney diseaseHistory of diabetesPAQ scoresPeripheral arterial diseaseOverall health statusSimilar health statusHealth status informationStudent's t-testLevel of diseaseRepeated-measures analysisInfrapopliteal disease
2019
Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status
Johnston AL, Vemulapalli S, Gosch KL, Aronow HD, Abbott JD, Patel MR, Smolderen KG, Shishebor M, Spertus JA, Jones WS. Ankle-brachial index in patients with intermittent claudication is a poor indicator of patient-centered and clinician-based evaluations of functional status. Journal Of Vascular Surgery 2019, 69: 906-912. PMID: 30626552, DOI: 10.1016/j.jvs.2018.07.039.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnkle Brachial IndexAustraliaCost of IllnessFemaleHealth StatusHemodynamicsHumansIntermittent ClaudicationMaleMiddle AgedNetherlandsPatient Reported Outcome MeasuresPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesQuality of LifeRegistriesSeverity of Illness IndexUnited StatesConceptsAnkle-brachial indexPeripheral artery diseasePeripheral Artery QuestionnaireIntermittent claudicationRutherford classificationABI valuesPAQ scoresArtery diseaseImpact of PADHealth statusMean ankle-brachial indexPAD-specific health statusSevere peripheral artery diseasePAQ summary scoreStudy of patientsQuality of lifeHealth status assessmentRutherford classNew onsetPatient's symptomsHemodynamic assessmentLife scoresFunctional statusPatients' perceptionsInternational cohort
2018
Associations of exercise ankle–brachial index, pain-free walking distance and maximum walking distance with the Peripheral Artery Questionnaire: Finding from the PORTRAIT PAD Registry
Hammad TA, Smolderen KG, Spertus JA, Jones PG, Shishehbor MH. Associations of exercise ankle–brachial index, pain-free walking distance and maximum walking distance with the Peripheral Artery Questionnaire: Finding from the PORTRAIT PAD Registry. Vascular Medicine 2018, 24: 32-40. PMID: 29992849, DOI: 10.1177/1358863x18785026.Peer-Reviewed Original ResearchConceptsPain-free walking distancePeripheral artery diseaseMaximum walking distancePeripheral Artery QuestionnairePhysical limitation scoreWalking distancePatient factorsLimitation scoresImpact of PADAnkle-brachial index (ABI) testExercise ankle-brachial indexOnset of claudicationPost-exercise ABIAnkle-brachial indexQuality of lifeHierarchical logistic regression modelsLogistic regression modelsPORTRAIT registryArtery diseasePatient's symptomsPatient functioningABI testingSummary scoresHealth statusSymptomsPORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease
Smolderen KG, Gosch K, Patel M, Jones WS, Hirsch AT, Beltrame J, Fitridge R, Shishehbor MH, Denollet J, Vriens P, Heyligers J, Stone MEd N, Aronow H, Abbott JD, Labrosciano C, Tutein-Nolthenius R, A Spertus J. PORTRAIT (Patient-Centered Outcomes Related to Treatment Practices in Peripheral Arterial Disease. Circulation Cardiovascular Quality And Outcomes 2018, 11: e003860. PMID: 29440123, DOI: 10.1161/circoutcomes.117.003860.Peer-Reviewed Original ResearchMeSH KeywordsAgedAustraliaCardiovascular AgentsExercise TherapyFemaleHealth StatusHealth Status IndicatorsHealthcare DisparitiesHumansIntermittent ClaudicationLife StyleMaleMiddle AgedMulticenter Studies as TopicNetherlandsPatient Outcome AssessmentPeripheral Arterial DiseaseProspective StudiesQuality of LifeRegistriesResearch DesignRisk FactorsSurveys and QuestionnairesTime FactorsTreatment OutcomeUnited StatesVascular Surgical ProceduresConceptsHealth status outcomesHealth statusMedical historyMedical recordsStatus outcomesAbnormal ankle-brachial indexPAD-related hospitalizationAnkle-brachial indexCardiovascular risk factorsMajor cardiovascular eventsPatients' medical recordsComparative effectiveness studiesHealth status dataPatient's medical historyPatients' health statusQuality of lifeClaudication symptomsEligible patientsCardiovascular eventsPAD symptomsPatient characteristicsClinician adherenceRisk stratificationLifestyle factorsFunctional status
2014
Determinants of invasive treatment in lower extremity peripheral arterial disease
van Zitteren M, Vriens PW, Burger DH, de Fijter WM, Gerritsen GP, Heyligers JM, Nooren MJ, Smolderen KG. Determinants of invasive treatment in lower extremity peripheral arterial disease. Journal Of Vascular Surgery 2014, 59: 400-408.e2. PMID: 24461863, DOI: 10.1016/j.jvs.2013.08.045.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAnkle Brachial IndexChi-Square DistributionDecision Support TechniquesEndovascular ProceduresFemaleHealth StatusHumansLower ExtremityMaleMiddle AgedNetherlandsOdds RatioPatient SelectionPeripheral Arterial DiseasePredictive Value of TestsProspective StudiesReferral and ConsultationRisk FactorsTreatment OutcomeUltrasonography, Doppler, DuplexVascular Surgical ProceduresConceptsPeripheral arterial diseaseLower extremity peripheral arterial diseasePhysical component scaleInvasive treatmentLesion locationHealth statusArterial diseaseTreatment referralSymptomatic lower extremity peripheral arterial diseaseProspective observational cohort studyVascular surgery outpatient clinicProximal lesion locationAnkle-brachial indexObservational cohort studySurgery outpatient clinicShort Form-12Poor health statusPatients' health statusPoisson regression analysisPAD diagnosisCohort studyPAD symptomsIndependent predictorsAmbulatory patientsForm-12
2010
Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States
Mahoney EM, Wang K, Keo HH, Duval S, Smolderen KG, Cohen DJ, Steg G, Bhatt DL, Hirsch AT. Vascular Hospitalization Rates and Costs in Patients With Peripheral Artery Disease in the United States. Circulation Cardiovascular Quality And Outcomes 2010, 3: 642-651. PMID: 20940249, DOI: 10.1161/circoutcomes.109.930735.Peer-Reviewed Original ResearchConceptsAsymptomatic peripheral artery diseasePeripheral artery diseaseAnkle-brachial indexArtery diseaseSymptomatic peripheral artery diseaseAtherothrombotic risk factorsContinued Health (REACH) RegistryCumulative hospitalization costsHistory of claudicationLimb ischemic eventsLower limb revascularizationReduction of AtherothrombosisInternational prospective registryAbsence of symptomsRisk of atherothrombosisLower limb amputationREACH cohortIntermittent claudicationProspective registryIschemic eventsPeripheral interventionsRevascularization proceduresArterial diseaseFirst admissionUS patientsYounger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms
Smolderen KG, Spertus JA, Vriens PW, Kranendonk S, Nooren M, Denollet J. Younger women with symptomatic peripheral arterial disease are at increased risk of depressive symptoms. Journal Of Vascular Surgery 2010, 52: 637-644. PMID: 20576397, DOI: 10.1016/j.jvs.2010.04.025.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAnkle Brachial IndexDepressionFemaleHealth Status DisparitiesHumansIncidenceLogistic ModelsMaleMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesProspective StudiesPsychiatric Status Rating ScalesRegistriesRisk AssessmentRisk FactorsSex FactorsTime FactorsConceptsPeripheral arterial diseaseSignificant depressive symptomsDepressive symptomsGender-age groupsYoung womenArterial diseaseSymptomatic peripheral arterial diseaseEpidemiological Studies Depression ScaleFourfold greater oddsVascular outpatient clinicAnkle-brachial indexPatients' depressive symptomsTime of diagnosisLogistic regression modelsImportant comorbidityPAD diagnosisPAD patientsClinical factorsDepression screeningOutpatient clinicCardiovascular diseaseDepression riskDepression ScaleAdditional adjustmentGreater odds
2009
Impact of peripheral arterial disease on health status: A comparison with chronic heart failure
Smolderen KG, Pelle AJ, Kupper N, Mols F, Denollet J. Impact of peripheral arterial disease on health status: A comparison with chronic heart failure. Journal Of Vascular Surgery 2009, 50: 1391-1398. PMID: 19958988, DOI: 10.1016/j.jvs.2009.07.109.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAmbulatory Care FacilitiesChronic DiseaseCost of IllnessCross-Sectional StudiesEducational StatusFemaleHeart DiseasesHeart FailureHumansLogistic ModelsMaleMarital StatusMental HealthMiddle AgedNetherlandsOdds RatioPeripheral Vascular DiseasesPropensity ScoreRisk AssessmentRisk FactorsSickness Impact ProfileConceptsPeripheral arterial diseaseChronic heart failurePhysical health statusMental health statusCHF patientsHealth statusPAD patientsCardiac historyDiabetes mellitusHeart failureArterial diseaseMedical recordsMedical conditionsImpact of PADLow ankle-brachial indexPatients' physical health statusYounger ageWorse physical health statusCross-sectional observational studyMental health status scoresComorbid diabetes mellitusAnkle-brachial indexClinical risk factorsHealth status scoresShort Form-12Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia
Smolderen KG, Hoeks SE, Pedersen SS, van Domburg RT, de Liefde II, Poldermans D. Lower-leg symptoms in peripheral arterial disease are associated with anxiety, depression, and anhedonia. Vascular Medicine 2009, 14: 297-304. PMID: 19808714, DOI: 10.1177/1358863x09104658.Peer-Reviewed Original ResearchConceptsAtypical leg symptomsPeripheral arterial diseaseExertional leg symptomsAnkle-brachial indexLeg symptomsIntermittent claudicationDepressive symptomsPAD patientsClinical factorsArterial diseaseAnkle-brachial index screeningSan Diego Claudication QuestionnaireClassic intermittent claudicationConsecutive PAD patientsLower leg symptomsDiverse clinical manifestationsErasmus Medical CenterMood statesSub-threshold symptomsCardiovascular historyMedication useTwofold riskClinical manifestationsPoor prognosisHospital AnxietyType D Personality and Mortality in Peripheral Arterial Disease: A Pilot Study
Aquarius AE, Smolderen KG, Hamming JF, De Vries J, Vriens PW, Denollet J. Type D Personality and Mortality in Peripheral Arterial Disease: A Pilot Study. JAMA Surgery 2009, 144: 728-733. PMID: 19687376, DOI: 10.1001/archsurg.2009.75.Peer-Reviewed Original ResearchConceptsPeripheral arterial diseaseType D personalityCause mortalityD personalityIndependent predictorsRenal diseaseArterial diseaseSymptomatic peripheral arterial diseasePilot studyAnkle-brachial indexHigh-risk patientsTraditional risk factorsPatients' medical filesMultivariable logistic regressionRisk of deathVascular surgery departmentType D ScaleClinical predictorsDiabetes mellitusPulmonary diseasePilot followMedical filesSurgery departmentRisk factorsTeaching hospital
2008
Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors
Smolderen KG, Aquarius AE, de Vries J, Smith OR, Hamming JF, Denollet J. Depressive symptoms in peripheral arterial disease: A follow-up study on prevalence, stability, and risk factors. Journal Of Affective Disorders 2008, 110: 27-35. PMID: 18237784, DOI: 10.1016/j.jad.2007.12.238.Peer-Reviewed Original ResearchConceptsAnkle-brachial indexPeripheral arterial diseaseDepressive symptomsPAD patientsArterial diseaseRisk factorsDepressed patientsSymptomatic lower extremity peripheral arterial diseaseLower extremity peripheral arterial diseaseEpidemiological Studies Depression ScaleTreadmill walking distanceCardiovascular risk factorsCoronary artery diseasePsychotropic medication useRelevant depressive symptomsOnly baseline dataPAD severityArtery diseaseMedication usePatient groupPoor prognosisClinical correlatesDepression ScaleClinical careWalking distance