How to Establish the Outer Limits of Reperfusion Therapy
Wechsler L, Jadhav A, Jovin T, Adeoye O, Albers G, Ansari S, Boltze J, Buchan A, Campbell B, Chaisinanunkul N, Chen C, Derdeyn C, Haddad W, Hill M, Holt W, Houser G, Khatri P, Krtolica A, Landen J, Lansberg M, Liebeskind D, Lyden P, Lynch J, Meinzer C, Mistry E, Mocco J, Nogueira R, Saver J, Savitz S, Schwamm L, Sheth K, Snyder M, Solberg Y, Vagal A, Venkatasubramanian C, Warach S, Ziogas N. How to Establish the Outer Limits of Reperfusion Therapy. Stroke 2021, 52: 3399-3403. PMID: 34470484, DOI: 10.1161/strokeaha.121.035022.Peer-Reviewed Original ResearchConceptsReperfusion therapyAcute ischemic strokeLarge pragmatic trialRoutine clinical practiceDrug Administration approvalTreatment effectsIntravenous alteplaseIschemic strokeStroke onsetEndovascular therapyRandomized trialsPragmatic trialImaging featuresAdministration approvalPlatform trialsSignificant treatment effectEffective treatmentTreatment efficacyAcademic centersClinical practiceTherapyPatientsTrialsMedical communityStatistical significanceAcute Stroke Imaging Research Roadmap IV: Imaging Selection and Outcomes in Acute Stroke Clinical Trials and Practice
Campbell B, Lansberg M, Broderick J, Derdeyn C, Khatri P, Sarraj A, Saver J, Vagal A, Albers G, Adeoye O, Ansari S, Boltze J, Buchan A, Chaisinanunkul N, Chen C, Davis T, Ermakova T, Fisher M, Haddad W, Hill M, Houser G, Jadhav A, Kimberly W, Landen J, Liebeskind D, Lyden P, Lynch J, Mansi C, Mocco J, Nogueira R, Savitz S, Schwamm L, Sheth K, Solberg Y, Venkatasubramanian C, Warach S, Wechsler L, Zhu B, Ziogas N. Acute Stroke Imaging Research Roadmap IV: Imaging Selection and Outcomes in Acute Stroke Clinical Trials and Practice. Stroke 2021, 52: 2723-2733. PMID: 34233464, PMCID: PMC8316368, DOI: 10.1161/strokeaha.121.035132.Peer-Reviewed Original ResearchConceptsPrimary stroke centerAcute stroke clinical trialsStroke centersStroke clinical trialsReperfusion therapyClinical trialsConsensus recommendationsComprehensive stroke centerAcute stroke trialsImaging sessionOptimal imaging strategyExtended time windowStroke neurologistsAcute strokeStroke trialsImaging selectionComputed tomographyTreatment windowUS FoodDrug AdministrationNeurological disordersStroke imagingTrialsNational InstituteOptimal imaging