2024
Fever Prevention in Patients With Acute Vascular Brain Injury
Greer D, Helbok R, Badjatia N, Ko S, Guanci M, Sheth K, Diringer M, Mehta Y, Cava L, Hinduja A, Lele A, Sarwal A, Kulik T, Keller E, Smith G, Dennesen P, Dimitriadis K, Schonenberger S, Gunther A, Meisel A, Wolf S, Kollmar R, Barlinn K, Jeon S, Han M, Hong J, Lee R, Falcone G, Dashti S, Busl K, Ermak D, Berkeley J, Amory C, Swor R, DeGeorgia M, Green-LaRoche D, Thompson B, Hatton K, Sung G, Mehta C, Zurasky J, Da Silva I, James M, Aysenne A, Cervantes A, Devlin T, Chang I, Morris N, Venkatasubramanian C, Mushlschlegel S, Zachariah J, Chaudry F, Claassen J, Dangayach N, Choi H, Sadaka F, Miller C. Fever Prevention in Patients With Acute Vascular Brain Injury. JAMA 2024, 332: 1525-1534. PMID: 39320879, PMCID: PMC11425189, DOI: 10.1001/jama.2024.14745.Peer-Reviewed Original ResearchVascular brain injuryStandard care groupCare groupMajor adverse eventsPrimary outcomeStandard care patientsBlinded outcome assessmentIntensive care unit dischargeFunctional outcomesAdverse eventsBrain injuryFever preventionFever burdenPrincipal secondary end pointBetween-group differencesOpen-label randomized clinical trialPrevention groupFunctional recoveryPrincipal secondary outcomeCare patientsAssociated with worse outcomesMain OutcomesImpact functional outcomesSecondary end pointsTemperature management device0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting
Schwarz J, Masroor K, Radulescu R, Tsang S, Sheth K, Redeker N, Yaggi H, Geer J. 0488 Exploring Study Recruitment Trends in the Acute Post-Stroke Setting. Sleep 2024, 47: a210-a210. DOI: 10.1093/sleep/zsae067.0488.Peer-Reviewed Original ResearchContinuous positive airway pressureObstructive sleep apneaPositive airway pressureAcute ischemic strokeAirway pressureUpper airway closureSleep-disordered breathingYale-New Haven HospitalCerebral blood flowOSA screeningOSA treatmentSleep apneaImpact cerebral blood flowAcademic medical centerSympathetic activityClinical trialsPatient populationHemodynamic changesRisk factorsPatientsFunctional recoveryExclusion criteriaAirway closureCardiovascular diseaseBlood flow
2023
Code ICH: A Call to Action
Li Q, Yakhkind A, Alexandrov A, Alexandrov A, Anderson C, Dowlatshahi D, Frontera J, Hemphill J, Ganti L, Kellner C, May C, Morotti A, Parry-Jones A, Sheth K, Steiner T, Ziai W, Goldstein J, Mayer S. Code ICH: A Call to Action. Stroke 2023, 55: 494-505. PMID: 38099439, DOI: 10.1161/strokeaha.123.043033.Peer-Reviewed Original ResearchIntracerebral hemorrhageHematoma expansionNeurological outcomeEarly aggressive careAcute ischemic strokeBlood pressure controlPoor functional outcomeMultiple simultaneous interventionsBundled careAggressive careIschemic strokeIndependent predictorsPrimary outcomeAcute phaseEmergency reversalFunctional recoveryRandomized trialsFunctional outcomeWorse outcomesConsensus statementCurrent evidenceTreatment opportunitiesSingle interventionEarly interventionPressure control