Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development
Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 8916-8921. PMID: 15951419, PMCID: PMC1157054, DOI: 10.1073/pnas.0503741102.Peer-Reviewed Original ResearchConceptsCardiac neural crest cellsNeural crest cellsNeural crestTranscription factorsMuscle differentiationSmooth muscle differentiationCrest cellsSmooth muscle cell differentiationTranscription factor BArch arteriesWnt-1 promoterCardiac outflow tract defectsMuscle cell differentiationMutant allele resultsNormal cardiovascular morphogenesisPremigratory neural crestCardiac neural crestGene trap micePattern of expressionCritical roleTranscriptional controlGene trapOutflow tract defectsAortic arch arteriesInsertional mutation