2005
Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development
Li J, Zhu X, Chen M, Cheng L, Zhou D, Lu MM, Du K, Epstein JA, Parmacek MS. Myocardin-related transcription factor B is required in cardiac neural crest for smooth muscle differentiation and cardiovascular development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2005, 102: 8916-8921. PMID: 15951419, PMCID: PMC1157054, DOI: 10.1073/pnas.0503741102.Peer-Reviewed Original ResearchConceptsCardiac neural crest cellsNeural crest cellsNeural crestTranscription factorsMuscle differentiationSmooth muscle differentiationCrest cellsSmooth muscle cell differentiationTranscription factor BArch arteriesWnt-1 promoterCardiac outflow tract defectsMuscle cell differentiationMutant allele resultsNormal cardiovascular morphogenesisPremigratory neural crestCardiac neural crestGene trap micePattern of expressionCritical roleTranscriptional controlGene trapOutflow tract defectsAortic arch arteriesInsertional mutation
2001
Binding of Serum Response Factor to CArG Box Sequences Is Necessary but Not Sufficient to Restrict Gene Expression to Arterial Smooth Muscle Cells*
Strobeck M, Kim S, Zhang J, Clendenin C, Du K, Parmacek M. Binding of Serum Response Factor to CArG Box Sequences Is Necessary but Not Sufficient to Restrict Gene Expression to Arterial Smooth Muscle Cells*. Journal Of Biological Chemistry 2001, 276: 16418-16424. PMID: 11279108, DOI: 10.1074/jbc.m100631200.Peer-Reviewed Original ResearchMeSH Keywords3' Untranslated Regions3T3 Cells5' Untranslated RegionsAnimalsAortaArteriesBase SequenceBeta-GalactosidaseBinding SitesCell LineCells, CulturedDNA-Binding ProteinsGene Expression RegulationGenes, fosHeartHeLa CellsHumansMiceMice, TransgenicMicrofilament ProteinsMolecular Sequence DataMuscle ProteinsMuscle, Smooth, VascularNuclear ProteinsPromoter Regions, GeneticRatsSequence DeletionSerum Response FactorTranscription FactorsConceptsSerum response factorBinding of SRFC-fos SRESM22alpha promoterCArG boxBind serum response factorActivity of SRFSmooth muscle cell developmentArterial SMCsMuscle cell developmentResponse factorTransgenic miceProtein binding assaysTransgene expressionBox sequenceDeletion analysisNuclear proteinsSME-1Arterial smooth muscle cellsGene expressionPromoter activityMolecular mechanismsCell developmentPromoterSmooth muscle cells