Analysis of SM22α-Deficient Mice Reveals Unanticipated Insights into Smooth Muscle Cell Differentiation and Function
Zhang J, Kim S, Helmke B, Yu W, Du K, Lu M, Strobeck M, Yu Q, Parmacek M. Analysis of SM22α-Deficient Mice Reveals Unanticipated Insights into Smooth Muscle Cell Differentiation and Function. Molecular And Cellular Biology 2001, 21: 1336-1344. PMID: 11158319, PMCID: PMC99586, DOI: 10.1128/mcb.2001.21.4.1336-1344.2001.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationEmbryonic and Fetal DevelopmentGene Expression Regulation, DevelopmentalGene TargetingLac OperonMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicMicrofilament ProteinsMuscle DevelopmentMuscle ProteinsMuscle, SmoothSignal TransductionTranscriptional ActivationConceptsVisceral SMCsBacterial lacZ reporter geneLocal mesenchymeWestern blot analysisSmooth muscle cell differentiationBeta-galactosidase activityBlood pressureControl littermatesHeart ratePostnatal developmentHomeostatic functionsHistological analysisMiceContractile SMCsBlot analysisDorsal aortaLittermatesAngiogenic programMuscle cell differentiationSM22alphaYolk sacCephalic mesenchymeCell differentiationLacZ reporter geneDetectable beta-galactosidase activity