PD-1 Blockade in Advanced Adrenocortical Carcinoma.
Raj N, Zheng Y, Kelly V, Katz SS, Chou J, Do RKG, Capanu M, Zamarin D, Saltz LB, Ariyan CE, Untch BR, O'Reilly EM, Gopalan A, Berger MF, Olino K, Segal NH, Reidy-Lagunes DL. PD-1 Blockade in Advanced Adrenocortical Carcinoma. Journal Of Clinical Oncology 2019, 38: 71-80. PMID: 31644329, PMCID: PMC7351334, DOI: 10.1200/jco.19.01586.Peer-Reviewed Original ResearchConceptsAdvanced adrenocortical carcinomaObjective response rateAdrenocortical carcinomaObjective responseResponse rateMedian progression-free survivalMismatch repair-deficient statusTreatment-related grade 3Disease control rateManageable safety profileMedian overall survivalPD-1 blockadePercent of patientsPhase II studyPrimary end pointProgression-free survivalDurable antitumor activityLimited treatment optionsMicrosatellite stable tumorsPrior therapyAdverse eventsII studyMedian durationOverall survivalStandard therapy