Featured Publications
Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study
Kauke-Navarro M, Panayi AC, Formica R, Marty F, Parikh N, Foroutanjazi S, Safi AF, Mardini S, Razonable RR, Morelon E, Gelb B, Rodriguez E, Lassus P, Pomahac B. Cytomegalovirus-related Complications and Management in Facial Vascularized Composite Allotransplantation: An International Multicenter Retrospective Cohort Study. Transplantation 2022, 106: 2031-2043. PMID: 35389381, DOI: 10.1097/tp.0000000000004132.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyAntiviral prophylaxisCohort studyComposite allotransplantationInternational multicenter retrospective cohort studyMulticenter retrospective cohort studyCMV-related complicationsFirst year posttransplantHigh-risk transplantsMore rejection episodesHigh-risk groupFacial Vascularized Composite AllotransplantationAllograft-related complicationsVascularized Composite AllotransplantationPaucity of dataAllograft lossCMV diseaseCMV viremiaCytomegalovirus serostatusR serostatusRejection episodesCMV infectionPrompt treatmentActive surveillancePatientsFull facial retransplantation in a female patient—Technical, immunologic, and clinical considerations
Kauke M, Panayi AC, Safi A, Haug V, Perry B, Kollar B, Nizzi M, Broyles J, Annino DJ, Marty FM, Sinha I, Lian CG, Murphy GF, Chandraker A, Pomahac B. Full facial retransplantation in a female patient—Technical, immunologic, and clinical considerations. American Journal Of Transplantation 2021, 21: 3472-3480. PMID: 34033210, DOI: 10.1111/ajt.16696.Peer-Reviewed Original ResearchConceptsChronic antibody-mediated rejectionPatient underwent retransplantationRecurrent cellular rejectionAntibody-mediated rejectionImmediate postoperative phaseInterposition vein graftAllograft lossCellular rejectionFirst allograftOlder allograftsRejection episodesUnderwent retransplantationSecond transplantationFirst transplantPostoperative outcomesAllotransplant recipientsPostoperative phaseVein graftsHyperacute rejectionFacial nerveOutcomes 6Arterial anastomosisRetransplantationSurgical techniquePsychosocial managementFace Transplantation in a Black Patient — Racial Considerations and Early Outcomes
Kauke M, Panayi AC, Tchiloemba B, Diehm YF, Haug V, Kollar B, Perry B, Singhal D, Sinha I, Riella LV, Annino DJ, Pomahac B. Face Transplantation in a Black Patient — Racial Considerations and Early Outcomes. New England Journal Of Medicine 2021, 384: 1075-1076. PMID: 33730460, PMCID: PMC8182672, DOI: 10.1056/nejmc2033961.Peer-Reviewed Original Research
2024
Letter in Reply to Comment on: Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes
Kauke-Navarro M, Klimitz F, Pomahac B. Letter in Reply to Comment on: Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes. Aesthetic Plastic Surgery 2024, 1-3. PMID: 39085527, DOI: 10.1007/s00266-024-04285-7.Peer-Reviewed Original ResearchAdvancements in facial implantology: a review of hydroxyapatite applications and outcomes
Kauke-Navarro M, Knoedler L, Knoedler S, Safi A. Advancements in facial implantology: a review of hydroxyapatite applications and outcomes. Frontiers In Surgery 2024, 11: 1409733. PMID: 39092153, PMCID: PMC11291363, DOI: 10.3389/fsurg.2024.1409733.Peer-Reviewed Original ResearchFacial skeletal reconstructionLong-term safetySkeletal reconstructionFacial balanceTumor resectionCraniofacial surgeryAesthetic resultsFacial implantsReconstructive surgeryWeb of Science databasesInclusion criteriaPatient outcomesPatient satisfactionPatientsImplant integrationSystematic reviewSurgeryFacial reconstructionHAP implantsOutcomesGoogle ScholarScience databasesEfficacyHydroxyapatite applicationImplantationC-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation
Kiefer J, Zeller J, Schneider L, Thomé J, McFadyen J, Hoerbrand I, Lang F, Deiss E, Bogner B, Schaefer A, Chevalier N, Horner V, Kreuzaler S, Kneser U, Kauke-Navarro M, Braig D, Woollard K, Pomahac B, Peter K, Eisenhardt S. C-reactive protein orchestrates acute allograft rejection in vascularized composite allotransplantation via subset-selective monocyte activation. Journal Of Advanced Research 2024 PMID: 38992424, DOI: 10.1016/j.jare.2024.07.007.Peer-Reviewed Original ResearchAcute allograft rejectionC-reactive proteinVascularized composite allotransplantationAllograft rejectionAcute rejectionAllograft survivalGraft rejectionAttenuate acute allograft rejectionPreventing acute allograft rejectionImmune responseLong-term allograft survivalFacial vascularized composite allotransplantationClinical allograft rejectionReduced allograft survivalChronic allograft rejectionIntravital imagingNon-classical monocytesMarkers of inflammationAcute-phase reactantsImmune-inflammatory reactionPro-inflammatory propertiesMononuclear phagocyte systemAcute-phase responseGraft infiltrationInnate immune responseSurgical Management of Breast Capsular Contracture—A Multi-institutional Data Analysis of Risk Factors for Early Complications
Knoedler S, Knoedler L, Boroumand S, Alfertshofer M, Diatta F, Sofo G, Huelsboemer L, Hansen F, Könneker S, Kim B, Perozzo F, Ayyala H, Allam O, Pomahac B, Kauke-Navarro M. Surgical Management of Breast Capsular Contracture—A Multi-institutional Data Analysis of Risk Factors for Early Complications. Aesthetic Plastic Surgery 2024, 1-12. PMID: 38926252, DOI: 10.1007/s00266-024-04203-x.Peer-Reviewed Original ResearchRisk factorsPostoperative complicationsCC surgeryInpatient settingMedical complicationsAmerican College of Surgeons National Surgical Quality Improvement Program databaseRisk factors of postoperative complicationsSurgeons National Surgical Quality Improvement Program databaseNational Surgical Quality Improvement Program databaseImplant-based breast surgeryMultivariate analysisPreoperative diagnosis of hypertensionFactors of postoperative complicationsQuality Improvement Program databaseLevel of Evidence IIIThis journalEvidence-Based Medicine ratingsAnalysis of risk factorsDay complication ratesDays follow-upEvidence IIIThis journalLevel of evidenceSurgical adverse eventsDiagnosis of hypertensionMulti-institutional dataTreatment of CCA Nationwide Analysis on Major Upper Extremity Amputations and Replantations.
Stögner V, Hauc S, Hosseini H, Williams M, Boroumand S, Huelsboemer L, Kauke-Navarro M, Pomahac B, Colen D. A Nationwide Analysis on Major Upper Extremity Amputations and Replantations. Hand 2024, 15589447241259189. PMID: 38907654, DOI: 10.1177/15589447241259189.Peer-Reviewed Original ResearchUpper extremity amputationExtremity amputationTraumatic upper extremity amputationsUtilization Project's National Inpatient SampleProportion of amputationsUrban teaching hospitalLevel of injuryNational Inpatient SampleNontraumatic amputationsUnited StatesHospital typeLength of stayInternational ClassificationTraumatic amputationHealthcare costsHighest burdenUpper extremityAlcohol useTeaching hospitalInpatient SamplePool of casesAmputationNational trendsNationwide analysisLow likelihoodQuality of life and satisfaction after breast augmentation: A systematic review and meta-analysis of Breast-Q patient-reported outcomes
Knoedler S, Knoedler L, Kauke-Navarro M, Alfertshofer M, Obed D, Broer N, Kim B, Könneker S, Panayi A, Hundeshagen G, Kneser U, Pomahac B, Haug V. Quality of life and satisfaction after breast augmentation: A systematic review and meta-analysis of Breast-Q patient-reported outcomes. Journal Of Plastic Reconstructive & Aesthetic Surgery 2024, 95: 300-318. PMID: 38945110, DOI: 10.1016/j.bjps.2024.06.016.Peer-Reviewed Original ResearchPhysical well-beingSexual well-beingWell-beingPatient-reported physical well-beingPatient reportsMeta-analysisPsychosocial well-beingPatient-reported outcomesPatient-reported quality of lifeBreast augmentationQuality of lifeHigher QoLPairwise meta-analysisA systematic reviewPatients' QoLPatient satisfactionSystematic reviewEligibility criteriaPRISMA guidelinesPostoperative follow-up timeQoLQuantitative synthesisFollow-up timeSubgroup analysisSatisfactionUnderstanding Epidemiological Trends in Geriatric Burn Injuries: A National Multicenter Analysis from NEISS 2004-2022
Boroumand S, Katsnelson B, Dony A, Stögner V, Huelsboemer L, Parikh N, Oh S, Kauke-Navarro M, Savetamal A, Pomahac B. Understanding Epidemiological Trends in Geriatric Burn Injuries: A National Multicenter Analysis from NEISS 2004-2022. Journal Of Burn Care & Research 2024, irae102. PMID: 38842413, DOI: 10.1093/jbcr/irae102.Peer-Reviewed Original ResearchGeriatric patientsRisk of hospital admissionAwareness of preventive measuresBurn injuryAffected body partED mortalityBurn epidemiologyNEISS databaseAdult patientsHospital admissionVulnerable populationsPatient morbidity/mortalityEpidemiological trendsLower legBurn etiologyProportion Z testAge groupsInjury sourcesMulticenter samplePatients to datePreventive measuresIncident locationLower armZ-testMulticenter analysisTurn Your Vision into Reality—AI-Powered Pre-operative Outcome Simulation in Rhinoplasty Surgery
Knoedler S, Alfertshofer M, Simon S, Panayi A, Saadoun R, Palackic A, Falkner F, Hundeshagen G, Kauke-Navarro M, Vollbach F, Bigdeli A, Knoedler L. Turn Your Vision into Reality—AI-Powered Pre-operative Outcome Simulation in Rhinoplasty Surgery. Aesthetic Plastic Surgery 2024, 1-6. PMID: 38777929, DOI: 10.1007/s00266-024-04043-9.Peer-Reviewed Original ResearchRhinoplasty surgeryRhinoplasty outcomesLevel of Evidence IIIThis journalEvidence-Based Medicine ratingsStudy participantsEvidence IIIThis journalLevel of evidencePre-operative consultationManaging patient expectationsResultsThe study sampleFemale study participantsPostoperative imagingPostoperative outcomesPatient photographsRhinoplasty patientsMale study participantsRhinoplastyPatient imagesPatient expectationsSurgeryGAN-generated imagesEffective doctor-patient communicationOnline InstructionsOutcomesDoctor-patient communicationTruth Lies in the Depths: Novel Insights into Facial Aesthetic Measurements from a U.S. Survey Panel
Knoedler L, Alfertshofer M, Geldner B, Sherwani K, Knoedler S, Kauke-Navarro M, Safi A. Truth Lies in the Depths: Novel Insights into Facial Aesthetic Measurements from a U.S. Survey Panel. Aesthetic Plastic Surgery 2024, 1-7. PMID: 38772944, DOI: 10.1007/s00266-024-04022-0.Peer-Reviewed Original ResearchFacial aestheticsFacial attractivenessLevel of Evidence IVThis journalEvidence-Based Medicine ratingsFacial bone surgeryFacial measurementsFacial soft tissuesLevel of evidenceMiddle-aged femalesMandibular projectionSurgical approachIVThis journalPerception of facial attractivenessFrontal photographsFacial implantsMethodsA totalTreatment conceptFacial surgeryFacial skeletonPotential treatmentSoft tissueBone surgeryAttractiveness ratingsConclusionThis studySurgeryD111. Ten year Follow up after Face Transplantation
Huelsboemer L, Kauke-Navarro M, Boroumand S, Parikh N, Hosseini H, Yu C, Stögner V, Ko C, Perry B, Formica R, Hung P, Mahajan A, Azzi J, Murphy G, Pomahac B. D111. Ten year Follow up after Face Transplantation. Plastic & Reconstructive Surgery Global Open 2024, 12: 120-121. PMCID: PMC11340540, DOI: 10.1097/01.gox.0001018916.83172.5e.Peer-Reviewed Original ResearchIncreased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty
Sanchez J, Rancu A, Diatta F, Jonnalagadda A, Dhodapkar M, Knoedler L, Kauke-Navarro M, Grauer J. Increased Risk of 90-Day Complications in Patients With Fibromyalgia Undergoing Total Shoulder Arthroplasty. JAAOS Global Research And Reviews 2024, 8: e24.00102. PMID: 38722914, PMCID: PMC11081627, DOI: 10.5435/jaaosglobal-d-24-00102.Peer-Reviewed Original ResearchConceptsRevision-free survivalDay of surgeryAdverse eventsTSA patientsIncreased riskMultivariate analysisOdds ratioIncreased risk of adverse eventsUrinary tract infectionLog-rank testRisk of adverse eventsSurgical site infectionSevere adverse eventsEffective treatment optionAcute kidney injuryDeep vein thrombosisMinor adverse eventsNon-fibromyalgia patientsEnd-stage glenohumeral osteoarthritisAssociation of fibromyalgiaIncreased odds ratioTotal shoulder arthroplastyShoulder infectionPulmonary embolismTract infectionsFrom standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases
Knoedler L, Huelsboemer L, Hollmann K, Alfertshofer M, Herfeld K, Hosseini H, Boroumand S, Stoegner V, Safi A, Perl M, Knoedler S, Pomahac B, Kauke-Navarro M. From standard therapies to monoclonal antibodies and immune checkpoint inhibitors – an update for reconstructive surgeons on common oncological cases. Frontiers In Immunology 2024, 15: 1276306. PMID: 38715609, PMCID: PMC11074450, DOI: 10.3389/fimmu.2024.1276306.Peer-Reviewed Original ResearchConceptsImmune checkpoint inhibitorsHead and neck cancerBreast cancerMonoclonal antibodiesCheckpoint inhibitorsSkin cancerReconstructive surgeryNon-surgical treatment strategiesProlonged progression-free survivalSuboptimal treatment plansProgression-free survivalNon-surgical therapySurgical tumor resectionImpaired patient outcomeStandardized treatment algorithmSurgical therapy planningAnti-cancer strategyUnresectable tumorsConventional chemotherapyRemission rateTumor resectionCurative therapyTargeted therapyNeck cancerOncology cases12. Functional Long-Term Outcome Of Eight Face Transplant Patients - A Single Center Study
Huelsboemer L, Stoegner V, Boroumand S, Parikh N, Hosseini H, Perry B, Formica R, Kauke-Navarro M, Pomahac B. 12. Functional Long-Term Outcome Of Eight Face Transplant Patients - A Single Center Study. Plastic & Reconstructive Surgery Global Open 2024, 12: 8-9. PMCID: PMC11041197, DOI: 10.1097/01.gox.0001015140.10439.0d.Peer-Reviewed Original ResearchCellular therapeutics and immunotherapies in wound healing – on the pulse of time?
Huelsboemer L, Knoedler L, Kochen A, Yu C, Hosseini H, Hollmann K, Choi A, Stögner V, Knoedler S, Hsia H, Pomahac B, Kauke-Navarro M. Cellular therapeutics and immunotherapies in wound healing – on the pulse of time? Military Medical Research 2024, 11: 23. PMID: 38637905, PMCID: PMC11025282, DOI: 10.1186/s40779-024-00528-5.Peer-Reviewed Original ResearchConceptsStandard of careChronic wound healing disordersLocal wound irrigationWound healingChronic inflammatory microenvironmentFree flap techniqueWound healing disordersChronic woundsGenetic risk profilesPhysiological wound healingAdequate blood supplySurgical debridementFlap techniqueCellular therapyCurrent therapiesHealing disordersInflammatory microenvironmentWound irrigationNon-healing woundsCellular therapeuticsGeneral anesthesiaFormation of biofilmsWound debridementSkin graftsImmunotherapyImmune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions
Knoedler L, Dean J, Diatta F, Thompson N, Knoedler S, Rhys R, Sherwani K, Ettl T, Mayer S, Falkner F, Kilian K, Panayi A, Iske J, Safi A, Tullius S, Haykal S, Pomahac B, Kauke-Navarro M. Immune modulation in transplant medicine: a comprehensive review of cell therapy applications and future directions. Frontiers In Immunology 2024, 15: 1372862. PMID: 38650942, PMCID: PMC11033354, DOI: 10.3389/fimmu.2024.1372862.Peer-Reviewed Original ResearchConceptsRegulatory myeloid cellsSolid organ transplantationVascularized composite allotransplantationMesenchymal stromal cellsT cellsTransplant patientsCellular therapyChimeric antigen receptor T cellsTransplant surgerySide effectsIncreased risk of malignancyProgression to chronic rejectionAcute rejection ratesPerioperative treatment strategiesRegulatory T cellsPromote immune toleranceRisk of malignancySystemic side effectsRelated side effectsCell typesImprove transplant survivalCAR-TCell therapy applicationsImmunosuppressive regimensChronic rejectionHard shell, soft core? Multi-disciplinary and multi-national insights into mental toughness among surgeons
Knoedler L, Dean J, Knoedler S, Kauke-Navarro M, Hollmann K, Alfertshofer M, Helm S, Prantl L, Schliermann R. Hard shell, soft core? Multi-disciplinary and multi-national insights into mental toughness among surgeons. Frontiers In Surgery 2024, 11: 1361406. PMID: 38645505, PMCID: PMC11027567, DOI: 10.3389/fsurg.2024.1361406.Peer-Reviewed Original ResearchMental toughnessGeneral life satisfactionLife satisfactionPrevalence of burnoutMental Toughness QuestionnaireCross-sectional designResilience-building programsHealthcare outcomesPatient safetyReduce burnoutTargeted interventionsInferential statistical analysesMedical professionalsPersonal well-beingPersonal life satisfactionProfessional dedicationPsychological skillsWell-beingSurgical performancePersonal factorsLongitudinal dataBurnoutStatistically significant higher levelsSatisfactionMulti-disciplinaryGynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes
Knoedler L, Knoedler S, Alfertshofer M, Hansen F, Schenck T, Sofo G, Obed D, Hollmann K, Siegwart L, Vollbach F, Bigdeli A, Kauke-Navarro M, Pomahac B. Gynecomastia Surgery in 4996 Male Patients Over 14 Years: A Retrospective Analysis of Surgical Trends, Predictive Risk Factors, and Short-Term Outcomes. Aesthetic Plastic Surgery 2024, 1-9. PMID: 38528130, DOI: 10.1007/s00266-024-03927-0.Peer-Reviewed Original ResearchACS-NSQIP databaseGynecomastia surgeryRisk factorsGS patientsACS-NSQIPBleeding disordersAmerican College of Surgeons National Surgical Quality Improvement ProgramSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramLevel of Evidence IIIThis journalSurgical Quality Improvement ProgramPreoperative risk factorsEvidence-Based Medicine ratingsInvestigate postoperative outcomesIndependent risk factorPredictive risk factorsShort-term outcomesMale adult patientsEvidence IIIThis journalPostoperative time periodLevel of evidencePredicting adverse eventsQuality Improvement ProgramGS casesGynecomastia cases