2017
Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation 1 , 2
Shams-White MM, Chung M, Du M, Fu Z, Insogna KL, Karlsen MC, LeBoff MS, Shapses SA, Sackey J, Wallace TC, Weaver CM. Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation 1 , 2. American Journal Of Clinical Nutrition 2017, 105: 1528-1543. PMID: 28404575, DOI: 10.3945/ajcn.116.145110.Peer-Reviewed Original ResearchConceptsBone mineral densityHigh protein intakeProspective cohort studyProtein intakeSystematic reviewCohort studyBone healthTotal hipFemoral neckModerate evidenceLumbar spine bone mineral densityTotal body bone mineral densityTH bone mineral densityLS bone mineral densityBody bone mineral densitySpine bone mineral densityFN bone mineral densityBone health measuresBone health outcomesDietary proteinLow protein intakeFull-text screeningStrength of evidenceOverall RoBNonpharmacologic approaches
2014
Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2
Bihuniak JD, Sullivan RR, Simpson CA, Caseria DM, Huedo-Medina TB, O’Brien K, Kerstetter JE, Insogna KL. Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2. Journal Of Nutrition 2014, 144: 282-288. PMID: 24431325, PMCID: PMC3927545, DOI: 10.3945/jn.113.185009.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionDual-stable calcium isotopesYoung womenUrinary calcium excretionDietary proteinControl diet periodAmino acid L-arginineHigh-protein dietAmino acid L-tryptophanCalcium excretionDiet periodClinical trialsSupplementation periodL-arginineDay 5Control dietRandom orderPhysiologic rangeDietTrialsWomenPossible benefitsL-tryptophan
2013
Dietary Acid Load Is Associated With Lower Bone Mineral Density in Men With Low Intake of Dietary Calcium
Mangano KM, Walsh SJ, Kenny AM, Insogna KL, Kerstetter JE. Dietary Acid Load Is Associated With Lower Bone Mineral Density in Men With Low Intake of Dietary Calcium. Journal Of Bone And Mineral Research 2013, 29: 500-506. PMID: 23873776, PMCID: PMC3946957, DOI: 10.1002/jbmr.2053.Peer-Reviewed Original ResearchConceptsPotential renal acid loadNet endogenous acid productionProximal femur bone mineral densityDietary acid loadFemur bone mineral densityBone mineral densityCalcium intakeDietary calciumAcid loadMineral densitySupplemental calciumHigh dietary acid loadNutrition Examination Survey 2005Low bone mineral densityMean bone mineral densityLow calcium intakeRenal acid loadLow dietary calciumEndogenous acid productionBone healthBMD sitesMean ageInverse associationNational HealthLow intake
2011
Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006
Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE. Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006. Journal Of The Academy Of Nutrition And Dietetics 2011, 111: 687-695. PMID: 21515114, PMCID: PMC3896234, DOI: 10.1016/j.jada.2011.02.014.Peer-Reviewed Original ResearchConceptsDietary calcium intakeCalcium intakeCalcium supplement useSupplement useAdult age groupsNational HealthAge groupsCalcium densityEnergy intakeNutrition Examination Survey respondentsTotal calciumNutrition Examination Survey 2003Nutrition Examination Survey dataAdequate intake standardsSupplemental calcium useMedian energy intakeAge 50 yearsYears age groupRecent National HealthOlder age groupsEnergy intake ratioAge-associated changesCross-sectional analysisBone healthDietary calcium
2003
Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans
Kerstetter JE, O'Brien KO, Insogna KL. Low Protein Intake: The Impact on Calcium and Bone Homeostasis in Humans. Journal Of Nutrition 2003, 133: 855s-861s. PMID: 12612169, DOI: 10.1093/jn/133.3.855s.BooksConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionHigh-protein dietProtein dietSecondary hyperparathyroidismUrinary calciumBone resorptionDietary proteinAdditional urinary calciumDietary protein resultsSerum parathyroid hormoneNutrition intervention trialCalcium balance studiesRecent epidemiological studiesLow protein intakeNutrition intervention studiesParathyroid hormoneBone lossSkeletal healthIntervention trialsCalcium metabolismSkeletal fracturesBone densityLong-term consequences
2001
Dietary protein and intestinal calcium absorption
Kerstetter J, O’Brien K, Insogna K. Dietary protein and intestinal calcium absorption. American Journal Of Clinical Nutrition 2001, 73: 990-991. PMID: 11333855, DOI: 10.1093/ajcn/73.5.990.Peer-Reviewed Original Research
1997
Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet
Kerstetter J, Caseria D, Mitnick M, Ellison A, Gay L, Liskov T, Carpenter T, Insogna K. Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet. American Journal Of Clinical Nutrition 1997, 66: 1188-1196. PMID: 9356538, DOI: 10.1093/ajcn/66.5.1188.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcifediolCalcium, DietaryDietDietary ProteinsFemaleHomeostasisHumansMineralsParathyroid HormoneSteroid 17-alpha-HydroxylaseConceptsLow-protein dietHigh-protein dietSerum PTHDietary proteinMedium protein dietCyclic adenosine monophosphateDay 4Nephrogenous cyclic adenosine monophosphateYoung womenIntestinal calcium absorptionNegative calcium balanceProtein-restricted dietSerum calcitriolUrinary calciumCalcitropic hormonesHealthy womenParathyroid hormoneBone turnSkeletal healthPTH bioactivityCalcium absorptionCalcium metabolismProtein restrictionRenal mechanismsMineral metabolism
1994
Dietary hypercalciuria in patients with calcium oxalate kidney stones
Burtis W, Gay L, Insogna K, Ellison A, Broadus A. Dietary hypercalciuria in patients with calcium oxalate kidney stones. American Journal Of Clinical Nutrition 1994, 60: 424-429. PMID: 8074077, DOI: 10.1093/ajcn/60.3.424.Peer-Reviewed Original ResearchConceptsCalcium excretionFree dietDietary hypercalciuriaKidney stonesUrinary calcium excretionHigh sodium intakeCalcium oxalate stonesHypercalciuric patientsSodium excretionUnselected patientsDietary sodiumSodium intakeDietary calciumDietary factorsDietary habitsPatientsHypercalciuriaExcretionOxalate stonesDietary proteinDietMultiple regression analysisCalciumStonesIntake
1993
Calcium and Kidney Stones
Burtis WJ, Broadus AE, Insogna KL. Calcium and Kidney Stones. New England Journal Of Medicine 1993, 329: 508-509. PMID: 8332168, DOI: 10.1056/nejm199308123290716.Peer-Reviewed Original Research
1992
Cross-cultural association between dietary animal protein and hip fracture: A hypothesis
Abelow B, Holford T, Insogna K. Cross-cultural association between dietary animal protein and hip fracture: A hypothesis. Calcified Tissue International 1992, 50: 14-18. PMID: 1739864, DOI: 10.1007/bf00297291.Peer-Reviewed Original ResearchConceptsHip fracture incidenceFracture incidenceDietary animal proteinHigh animal protein dietTotal caloric intakeAnimal protein dietHip fractureDietary calciumFracture ratesCaloric intakeBone bufferingFracture associationMetabolic acid productionBone dissolutionProtein dietFurther studiesPositive associationProtein consumptionAnimal proteinIncidenceAssociationAnimal protein consumptionRecent studies
1989
Trichlormethiazide and Oral Phosphate Therapy in Patients with Absorptive Hypercalciuria
Insogna K, Ellison A, Burtis W, Sartori L, Lang R, Broadus A. Trichlormethiazide and Oral Phosphate Therapy in Patients with Absorptive Hypercalciuria. Journal Of Urology 1989, 141: 269-273. PMID: 2913343, DOI: 10.1016/s0022-5347(17)40737-3.Peer-Reviewed Original ResearchConceptsOral phosphate therapyDihydroxyvitamin D levelsAbsorptive hypercalciuriaUrinary calciumParathyroid functionPhosphate therapyPhosphate administrationD levelsOral phosphate administrationRenal phosphate thresholdTreatment urinary calciumStudy 36 patientsPre-treatment valuesTrichlormethiazide treatmentCalcium excretionDihydroxyvitamin DBiochemical abnormalitiesSecond drugPharmacological meansStudy subjectsHypercalciuriaPatientsTherapyPer cent decreaseTreatment
1987
Concerning the Pathogenesis of Idiopathic Hypercalciuria1
Broadus AE, Burtis WJ, Oren DA, Sartori L, Gay L, Ellison AF, Insogna KL. Concerning the Pathogenesis of Idiopathic Hypercalciuria1. Contributions To Nephrology 1987, 58: 127-136. PMID: 3691116, DOI: 10.1159/000414502.Books
1985
Sensitivity of the Parathyroid Hormone–1, 25-Dihydroxyvitamin D Axis to Variations in Calcium Intake in Patients with Primary Hyperparathyroidism
Insogna K, Mitnick M, Stewart A, Burtis W, Mallette L, Broadus A. Sensitivity of the Parathyroid Hormone–1, 25-Dihydroxyvitamin D Axis to Variations in Calcium Intake in Patients with Primary Hyperparathyroidism. New England Journal Of Medicine 1985, 313: 1126-1130. PMID: 2995810, DOI: 10.1056/nejm198510313131805.Peer-Reviewed Original ResearchConceptsPrimary hyperparathyroidismParathyroid functionParathyroid hormone-vitamin D axisAutonomous parathyroid functionNephrogenous cyclic AMPImmunoreactive parathyroid hormoneNormal dietary intakeExtracellular calcium concentrationParathyroid hormone 1Calcium excretionCalcium intakeUnselected patientsSerum levelsParathyroid hormoneDihydroxyvitamin DDietary calciumPlasma levelsDietary intakePhysiologic amountsHyperparathyroidismPatientsHormone 1Calcium concentrationCyclic AMPSignificant reduction
1984
Evidence for Disordered Control of 1,25-Dihydroxyvitamin D Production in Absorptive Hypercalciuria
Broadus A, Insogna K, Lang R, Ellison A, Dreyer B. Evidence for Disordered Control of 1,25-Dihydroxyvitamin D Production in Absorptive Hypercalciuria. New England Journal Of Medicine 1984, 311: 73-80. PMID: 6330548, DOI: 10.1056/nejm198407123110201.Peer-Reviewed Original ResearchMeSH KeywordsAdultCalcitriolCalciumCalcium Metabolism DisordersCalcium, DietaryCyclic AMPFemaleHumansKidney TubulesMaleMiddle AgedPhosphatesConceptsAbsorptive hypercalciuriaCalcium intakeDietary calcium intakeDihydroxyvitamin D productionRenal phosphate handlingDihydroxyvitamin DPhosphate handlingSuppression testHypercalciuriaPatientsD productionShort-term increaseSyndromeIntakePresent studyInitial levelLarge majorityPrevious studiesEvidenceAbnormalitiesWeeksHypercalciuria as a metabolic disease.
Insogna KL, Broadus AE. Hypercalciuria as a metabolic disease. Urologic Oncology Seminars And Original Investigations 1984, 2: 20-33. PMID: 6463459.Books
1981
Effect of Age on Serum Immunoreactive Parathyroid Hormone and Its Biological Effects*
INSOGNA K, LEWIS A, LIPINSKI B, BRYANT C, BARAN D. Effect of Age on Serum Immunoreactive Parathyroid Hormone and Its Biological Effects*. The Journal Of Clinical Endocrinology & Metabolism 1981, 53: 1072-1075. PMID: 6270181, DOI: 10.1210/jcem-53-5-1072.Peer-Reviewed Original ResearchConceptsIPTH levelsElderly subjectsTubular maximum phosphate reabsorptionImmunoreactive parathyroid hormone levelsSerum immunoreactive parathyroid hormoneImmunoreactive parathyroid hormoneParathyroid hormone levelsBiological effectsCreatinine clearanceEffect of ageNephrogenous cAMPUrinary calciumCreatinine ratioSerum phosphateParathyroid hormoneBone lossCalcium ingestionBone resorptionPhosphate reabsorptionHormone levelsHealthy volunteersSignificant negative correlationSignificant positive correlationIPTHOlder volunteers