1999
Bone Densities in Patients Receiving Isotretinoin for Cystic Acne
Leachman SA, Insogna KL, Katz L, Ellison A, Milstone LM. Bone Densities in Patients Receiving Isotretinoin for Cystic Acne. JAMA Dermatology 1999, 135: 961-965. PMID: 10456346, DOI: 10.1001/archderm.135.8.961.Peer-Reviewed Original ResearchConceptsCystic acneBone densityWard's triangleCalcium metabolismHealthy control subjectsYoung menIsotretinoin useOral isotretinoinPatient groupControl subjectsMean changeHealthy volunteersControl groupAcnePatientsMeasurable alterationsIsotretinoinFurther studiesOsteoporosisDecreased densityRetinoidsMetabolismMenBoneDirect effect
1992
The Effects of Isotretinoin on the Axial Skeleton and the Retinoid Effect-Reply
Milstone L, Insogna K. The Effects of Isotretinoin on the Axial Skeleton and the Retinoid Effect-Reply. JAMA Dermatology 1992, 128: 1650-1650. DOI: 10.1001/archderm.1992.04530010086018.Commentaries, Editorials and LettersSecondary hyperparathyroidismBone demineralizationEffect of isotretinoinDisorders of keratinizationRole of retinoidsExtraskeletal calcificationHypervitaminosis ACompression fracturesIndex patientsExperimental animalsLoss of calciumRetinoidsLong bonesHyperparathyroidismAxial skeletonPatientsIngestionBoneDemineralizationIsotretinoinOsteopeniaHumansLucencyCalcificationKeratinization