Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum
Yadav VK, Ryu JH, Suda N, Tanaka KF, Gingrich JA, Schütz G, Glorieux FH, Chiang CY, Zajac JD, Insogna KL, Mann JJ, Hen R, Ducy P, Karsenty G. Lrp5 Controls Bone Formation by Inhibiting Serotonin Synthesis in the Duodenum. Cell 2008, 135: 825-837. PMID: 19041748, PMCID: PMC2614332, DOI: 10.1016/j.cell.2008.09.059.Peer-Reviewed Original ResearchConceptsBone massBone formationLrp5-deficient miceSerotonin blood levelsExpression of TPH1High bone massOsteoblast-specific disruptionRate-limiting biosynthetic enzymeBone lossEnterochromaffin cellsBlood levelsSerotonin synthesisPotential therapyBone remodelingWnt coreceptorSerotoninLRP5Function mutationsDuodenumTPH1Independent mannerOsteoporosisTherapyBiosynthetic enzymesMice