Evidence for a Functional Association between Phosphatidylinositol 3-Kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1*
Grey A, Chen Y, Paliwal I, Carlberg K, Insogna K. Evidence for a Functional Association between Phosphatidylinositol 3-Kinase and c-src in the Spreading Response of Osteoclasts to Colony-Stimulating Factor-1*. Endocrinology 2000, 141: 2129-2138. DOI: 10.1210/en.141.6.2129.Peer-Reviewed Original ResearchC-SrcPhosphatidylinositol 3-kinasePI3K activityColony-stimulating factor-1SH3 domainPI3KSH3 domain of c-SrcRegulatory subunit of PI3KActivation of phosphatidylinositol 3-kinaseSubunit of PI3KProline-rich sequenceActivation of PI3KIntracellular signaling moleculesRegulatory subunitOsteoclast cytoskeletonCytoskeletal changesColony-stimulating factor 1 treatmentOsteoclast motilitySignaling moleculesFunctional associationGrowth factor/cytokineSignaling pathwayInhibitor wortmanninTreatment of osteoclast-like cellsReceptor c-fms