1996
Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary hyperparathyroidism and correlate with markers of bone resorption--a clinical research center study
Grey A, Mitnick MA, Shapses S, Ellison A, Gundberg C, Insogna K. Circulating levels of interleukin-6 and tumor necrosis factor-alpha are elevated in primary hyperparathyroidism and correlate with markers of bone resorption--a clinical research center study. The Journal Of Clinical Endocrinology & Metabolism 1996, 81: 3450-3454. PMID: 8855783, DOI: 10.1210/jcem.81.10.8855783.Peer-Reviewed Original ResearchConceptsPrimary hyperparathyroidismUntreated primary hyperparathyroidismSerum type ITumor necrosisInterleukin-6Bone resorptionSerum levelsBiochemical markersSerum deoxypyridinolineUrinary deoxypyridinolineUrinary pyridinolineBone lossCarboxyterminal telopeptideSoluble receptorClinical research center studyControl valuesNormal parathyroid functionSuccessful surgical treatmentBone-resorbing cytokinesInterleukin-1 betaType IIntact PTHParathyroid functionSurgical treatmentCenter study
1990
THE PARATHYROID HORMONE-RELATED PROTEIN STIMULATES HUMAN OSTEOBLAST-LIKE CELLS TO SECRETE A 9,000 DALTON BONERESORBING PROTEIN
Morris CA, Mitnick ME, Weir EC, Horowitz M, Kreider BL, Insogna KL. THE PARATHYROID HORMONE-RELATED PROTEIN STIMULATES HUMAN OSTEOBLAST-LIKE CELLS TO SECRETE A 9,000 DALTON BONERESORBING PROTEIN. Endocrinology 1990, 126: 1783-1786. PMID: 2307127, DOI: 10.1210/endo-126-3-1783.Peer-Reviewed Original ResearchConceptsParathyroid hormone-related proteinBone-resorbing activityHormone-related proteinBone resorptionPTH/Bone-resorbing cytokinesIL-1GM-CSFSingle fractionSequential reverse-phase HPLCII cellsUntreated cellsKD fractionHuman osteoblast-like cellsResorptionSize-exclusion HPLCNgeqOsteoblast-like cellsSpecific activityCellsKD proteinOsteoblastsReversed-phase HPLCCytokinesPGE2