2014
Cell-Cell Adhesions and Cell Contractility Are Upregulated upon Desmosome Disruption
Sumigray K, Zhou K, Lechler T. Cell-Cell Adhesions and Cell Contractility Are Upregulated upon Desmosome Disruption. PLOS ONE 2014, 9: e101824. PMID: 25006807, PMCID: PMC4090201, DOI: 10.1371/journal.pone.0101824.Peer-Reviewed Original ResearchConceptsAdherens junctionsMyosin IIAAdhesion structuresAnti-Dsg3 antibodiesCell-cell adhesion structuresCell adhesion structuresCell-cell adhesionMyosin II activityDesmosomal protein desmoplakinDesmosome functionTransmembrane componentBarrier functionClaudin genesGenetic disordersSignificant increaseMouse keratinocytesCell contractilityDisruption resultsPosttranslational changesTight junctionsII activity
2012
Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium
Sumigray KD, Lechler T. Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. Molecular Biology Of The Cell 2012, 23: 792-799. PMID: 22238362, PMCID: PMC3290639, DOI: 10.1091/mbc.e11-11-0923.Peer-Reviewed Original ResearchConceptsDesmosomal protein desmoplakinProper cell-cell adhesionCell adhesionSimple epitheliaCell adhesion structuresApical junctional regionCell-cell adhesionTissue-specific functionsFunction of desmosomesKeratin filament networkTight junctionsKeratin organizationAdherens junctionsTissue homeostasisIntestinal epitheliumAdhesion structuresFilament networkCanonical functionFilament localizationKeratin filamentsMicrovilli lengthMicrovillus structureStratified epitheliumDesmoplakinDesmosomes