2022
Inactivity is associated with worse cognition and neurodegeneration in aging adults
Gogniat M, Khan O, Li J, Park C, Robb W, Moore E, Houston M, Pechman K, Liu D, Hohman T, Gifford K, Jefferson A. Inactivity is associated with worse cognition and neurodegeneration in aging adults. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.067713.Peer-Reviewed Original ResearchCommunity-dwelling older adultsAPOE e4 statusEpisodic memory performanceGray matter volumeE4 statusPhysical activityOlder adultsMemory performanceMatter volumeAging adultsGenetic riskGreater physical activityAverage daily minutesIncreased physical activityFramingham Stroke Risk Profile scoreAPOE-e4 statusStratified modelsAssociated with worse cognitionCortical thicknessModifiable risk factorsTotal gray matter volumeBrain aging outcomesDays of wrist actigraphyE4 carriersParietal lobe volume
2021
Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Li J, Moore E, Cambronero F, Pechman K, Liu D, Gifford K, Landman B, Donahue M, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease-related neurodegeneration and poorer cognitive performance among apolipoprotein E ε4 carriers. Cerebrovascular And Brain Metabolism Reviews 2021, 42: 642-655. PMID: 34743630, PMCID: PMC9051148, DOI: 10.1177/0271678x211056393.Peer-Reviewed Original ResearchConceptsEpisodic memory performanceCognitive performancePathogenesis of Alzheimer's diseaseMemory performanceAlzheimer's disease-related neurodegenerationPoorer cognitive performanceE4 carriersLateral ventricle volumeExecutive functionEpisodic memoryOxygen homeostasisDisease-related neurodegenerationAlzheimer's diseaseBrain agingCognitive impairmentNeuroimaging variablesE4 statusCerebral metabolic rateVentricle volumeOlder adultsBad languageHippocampalNeurodegenerationMetabolic rateMetabolismAssociation of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration
Moore E, Liu D, Li J, Schimmel S, Cambronero F, Terry J, Nair S, Pechman K, Moore M, Bell S, Beckman J, Gifford K, Hohman T, Blennow K, Zetterberg H, Carr J, Jefferson A. Association of Aortic Stiffness With Biomarkers of Neuroinflammation, Synaptic Dysfunction, and Neurodegeneration. Neurology 2021, 97: e329-e340. PMID: 34031194, PMCID: PMC8362359, DOI: 10.1212/wnl.0000000000012257.Peer-Reviewed Original ResearchConceptsPulse wave velocitySynaptic dysfunctionYears of ageParticipants free of strokeP-tauMemory and Aging ProjectFramingham Stroke Risk ProfileFree of strokeT-tauAortic pulse wave velocityCommunity-based studyObservational community-based studyAssociation of aortic stiffnessStroke Risk ProfileAging ProjectOlder adultsTau phosphorylationE4 statusAlzheimer's disease pathologyHypertension statusCentral arterial stiffeningHigher aortic pulse wave velocityYKL-40Risk profileCognitive diagnosis
2020
Lower cerebral oxygen utilization is associated with Alzheimer’s disease‐related neurodegeneration on MRI and poorer cognitive performances among apolipoprotein E ε4 carriers
Robb W, Khan O, Ahmed H, Liu D, Moore E, Li J, Cambronero F, Pechman K, Gifford K, Landman B, Hohman T, Jefferson A. Lower cerebral oxygen utilization is associated with Alzheimer’s disease‐related neurodegeneration on MRI and poorer cognitive performances among apolipoprotein E ε4 carriers. Alzheimer's & Dementia 2020, 16 DOI: 10.1002/alz.046467.Peer-Reviewed Original ResearchAPOE e4 statusE4 statusModified associationsParticipants free of strokeAPOE e4 carriersFramingham Stroke Risk ProfileFree of strokeClinical Dementia RatingApolipoprotein E e4 carriersE4 carriersWorse cognitive performanceStroke Risk ProfileNeuroimaging variablesCognitive performancePoorer cognitive performanceDementia RatingGenetic risk factorsOlder adultsAlzheimer's disease-related neurodegenerationGray matter volumeAlzheimer's diseaseRisk factorsRisk profileApo E4Matter volume