2024
Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact
Zhang X, Noah J, Singh R, McPartland J, Hirsch J. Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact. Scientific Reports 2024, 14: 3232. PMID: 38332184, PMCID: PMC10853508, DOI: 10.1038/s41598-024-53942-z.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderAutism Diagnostic Observation Schedule scoresEye-to-eye contactSocial difficultiesNeural processesNeural responsesObservation ScheduleSymptoms of autism spectrum disorderBehavioural symptoms of autism spectrum disorderNeural activity patternsLive interaction paradigmTD groupSupport vector machineNeural mechanismsSymptom severityADOS scoresBehavioral symptomsSpectrum disorderASD diagnosisNeural dataActivity patternsAutismClassification methodMultivariate classification methods
2023
Quantification of inter-brain coupling: A review of current methods used in haemodynamic and electrophysiological hyperscanning studies
Hakim U, De Felice S, Pinti P, Zhang X, Noah J, Ono Y, Burgess P, Hamilton A, Hirsch J, Tachtsidis I. Quantification of inter-brain coupling: A review of current methods used in haemodynamic and electrophysiological hyperscanning studies. NeuroImage 2023, 280: 120354. PMID: 37666393, DOI: 10.1016/j.neuroimage.2023.120354.Peer-Reviewed Original ResearchConceptsInter-brain couplingHyperscanning studyFunctional magnetic resonanceBrain imaging modalitiesSocial neuroscienceCognitive mechanismsSocial anxietyBrain couplingCognitive researchSocial interactionHyperscanningMental healthDifferent modalitiesMagnetoencephalographyDevelopmental conditionsElectroencephalographyMore participantsParticipantsAutismNeuroscienceFNIRSAnxietyBrainModalitiesSchizophreniaNeural mechanisms for emotional contagion and spontaneous mimicry of live facial expressions
Hirsch J, Zhang X, Noah J, Bhattacharya A. Neural mechanisms for emotional contagion and spontaneous mimicry of live facial expressions. Philosophical Transactions Of The Royal Society B Biological Sciences 2023, 378: 20210472. PMID: 36871593, PMCID: PMC9985973, DOI: 10.1098/rstb.2021.0472.Peer-Reviewed Original ResearchConceptsEmotional contagionFacial expressionsFacial mimicryNeural correlatesAffect ratingsDyadic partnersFace processing areasRatings of emotionDistinct neural componentsShort movie clipsTwo-person paradigmFacial action unitsSpontaneous mimicryNeural underpinningsEmotional experienceNeural mechanismsSupramarginal gyrusNatural facial expressionsAction unitsRest blocksMovie clipsSocial interactionFacial classificationMovie watchersDyadic roleVolume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group
Groenewold N, Bas-Hoogendam J, Amod A, Laansma M, Van Velzen L, Aghajani M, Hilbert K, Oh H, Salas R, Jackowski A, Pan P, Salum G, Blair J, Blair K, Hirsch J, Pantazatos S, Schneier F, Talati A, Roelofs K, Volman I, Blanco-Hinojo L, Cardoner N, Pujol J, Beesdo-Baum K, Ching C, Thomopoulos S, Jansen A, Kircher T, Krug A, Nenadić I, Stein F, Dannlowski U, Grotegerd D, Lemke H, Meinert S, Winter A, Erb M, Kreifelts B, Gong Q, Lui S, Zhu F, Mwangi B, Soares J, Wu M, Bayram A, Canli M, Tükel R, Westenberg P, Heeren A, Cremers H, Hofmann D, Straube T, Doruyter A, Lochner C, Peterburs J, Van Tol M, Gur R, Kaczkurkin A, Larsen B, Satterthwaite T, Filippi C, Gold A, Harrewijn A, Zugman A, Bülow R, Grabe H, Völzke H, Wittfeld K, Böhnlein J, Dohm K, Kugel H, Schrammen E, Zwanzger P, Leehr E, Sindermann L, Ball T, Fonzo G, Paulus M, Simmons A, Stein M, Klumpp H, Phan K, Furmark T, Månsson K, Manzouri A, Avery S, Blackford J, Clauss J, Feola B, Harper J, Sylvester C, Lueken U, Veltman D, Winkler A, Jahanshad N, Pine D, Thompson P, Stein D, Van der Wee N. Volume of subcortical brain regions in social anxiety disorder: mega-analytic results from 37 samples in the ENIGMA-Anxiety Working Group. Molecular Psychiatry 2023, 28: 1079-1089. PMID: 36653677, PMCID: PMC10804423, DOI: 10.1038/s41380-022-01933-9.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderSubcortical brain regionsAnxiety disordersSAD patientsBilateral putamen volumesSubcortical regionsBrain regionsLinear mixed effects analysisComorbid anxiety disordersSubcortical volumesFamily-wise errorPutamen volumeSAD onsetVolumetric differencesPallidum volumeMixed effects analysisD effect sizesInconsistent findingsLeft putamenEffect sizeFull samplePrevious findingsInternational sampleSignificant interactionLimited convergence
2022
Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder
Fertuck E, Stanley B, Kleshchova O, Mann J, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Grinband J. Rejection Distress Suppresses Medial Prefrontal Cortex in Borderline Personality Disorder. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 8: 651-659. PMID: 36868964, PMCID: PMC10388534, DOI: 10.1016/j.bpsc.2022.11.006.Peer-Reviewed Original ResearchConceptsBorderline personality disorderRejection distressFunctional magnetic resonancePrefrontal cortex responsesCortex responsesPrefrontal cortexPersonality disorderControl participantsWhole-brain responsesNeural responsesFunctional magnetic resonance imagingMagnetic resonance imagingMedial prefrontal cortexHealthy control participantsUnivariate analysisMagnetic resonanceBPD groupResonance imagingNovel functional magnetic resonanceGroup differencesRostromedial prefrontal cortexNeural substratesBrain activityDistressNeural mechanismsNeural correlates of eye contact and social function in autism spectrum disorder
Hirsch J, Zhang X, Noah J, Dravida S, Naples A, Tiede M, Wolf J, McPartland J. Neural correlates of eye contact and social function in autism spectrum disorder. PLOS ONE 2022, 17: e0265798. PMID: 36350848, PMCID: PMC9645655, DOI: 10.1371/journal.pone.0265798.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderDorsal parietal regionsNeural correlatesEye contactLive eyesNeural responsesSpectrum disorderAutism Diagnostic Observation ScheduleUnderlying neural correlatesSocial Responsiveness ScaleGold standard measureCentral diagnostic criterionDiagnostic criteriaDiagnostic biomarkersSRS-2ADOS-2Responsiveness ScaleObservation ScheduleParietal regionsPupillometry dataNeural systemsEyesNatural interactionDisordersCorrelatesAn Approach to Neuroimaging Interpersonal Interactions in Mental Health Interventions
Crum J, Zhang X, Noah A, Hamilton A, Tachtsidis I, Burgess PW, Hirsch J. An Approach to Neuroimaging Interpersonal Interactions in Mental Health Interventions. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 669-679. PMID: 35144035, PMCID: PMC9271588, DOI: 10.1016/j.bpsc.2022.01.008.Peer-Reviewed Original ResearchConceptsInterpersonal interactionsPrefrontal cortexRostral prefrontal cortexInferior parietal lobuleMental health interventionsNeural underpinningsDysfunctional cognitionsBrain systemsEcological validityPrefrontal systemsParietal lobuleNeural couplingNeuroimaging techniquesVerbal communicationVerbal interactionClinical neuroscienceMental healthCortexClinical situationsClinical settingClinical tasksClinical interactionsParadigmHealth interventionsCognition
2021
Bidirectional Connectivity Between Broca's Area and Wernicke's Area During Interactive Verbal Communication
Ono Y, Zhang X, Noah JA, Dravida S, Hirsch J. Bidirectional Connectivity Between Broca's Area and Wernicke's Area During Interactive Verbal Communication. Brain Connectivity 2021, 12: 210-222. PMID: 34128394, PMCID: PMC9058861, DOI: 10.1089/brain.2020.0790.Peer-Reviewed Original ResearchConceptsWernicke's areaNeural mechanismsBroca's areaDirectional connectivityHealthy adult participantsHemodynamic responseBidirectional connectivityFunctional connectivityNeural modulationBrainNeuronal informationSpeech areasNeural activityAdult participantsBrocaContrast findingsHuman brainImpact statementNeural dynamicsBrain modelFindingsWernicke'sSocial functionGranger causality analysisVerbal condition
2020
Facial and neural mechanisms during interactive disclosure of biographical information
Cañigueral R, Zhang X, Noah JA, Tachtsidis I, Hamilton AFC, Hirsch J. Facial and neural mechanisms during interactive disclosure of biographical information. NeuroImage 2020, 226: 117572. PMID: 33221448, PMCID: PMC7612862, DOI: 10.1016/j.neuroimage.2020.117572.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultCerebral CortexDisclosureEye Movement MeasurementsFacial ExpressionFacial MusclesFemaleFixation, OcularFunctional NeuroimagingHumansMaleMiddle AgedParietal LobePrefrontal CortexSelf DisclosureSignal Processing, Computer-AssistedSocial InteractionSpectroscopy, Near-InfraredTemporal LobeYoung AdultConceptsNeurocognitive mechanismsFacial displaysCommunicative interactionMore eye gazeNon-interactive situationsPairs of participantsBiographical informationBilateral TPJRight TPJLeft SMGNeuroscience hypothesisNeural mechanismsEye gazeMultimodal findingsBrain activitySocial signalingTPJDLPFCMutual sharingParticipantsSpontaneous productionLong-range mechanismsGazeDisplaySynchronyNeural processes for live pro-social dialogue between dyads with socioeconomic disparity
Descorbeth O, Zhang X, Noah JA, Hirsch J. Neural processes for live pro-social dialogue between dyads with socioeconomic disparity. Social Cognitive And Affective Neuroscience 2020, 15: 875-887. PMID: 32879986, PMCID: PMC7543936, DOI: 10.1093/scan/nsaa120.Peer-Reviewed Original ResearchConceptsDorsolateral pre-frontal cortexFrontal lobe hypothesisFrontal lobe processesFrontal lobe networksPre-frontal cortexGroups of dyadsNeural processesNovel neuroimaging techniquesFrontopolar areaNeural activationPars triangularisSpeech dialogueNeuroimaging techniquesDialectic discourseDyadsNeural functionTheoretical frameworkSocioeconomic backgroundHemodynamic signalsSocioeconomic statusAnxietyStereotypingNeuroimagingPrejudiceTriangularis
2019
Remote photonic sensing of cerebral hemodynamic changes via temporal spatial analysis of acoustic vibrations
Ozana N, Noah JA, Zhang X, Ono Y, Hirsch J, Zalevsky Z. Remote photonic sensing of cerebral hemodynamic changes via temporal spatial analysis of acoustic vibrations. Journal Of Biophotonics 2019, 13: e201900201. PMID: 31415118, DOI: 10.1002/jbio.201900201.Peer-Reviewed Original ResearchConceptsHemodynamic changesCerebral hemodynamic changesNeural activityTask-specific neural activityVisual checkerboard stimulationHuman brain activationHemodynamic responseOccipital lobeBlood flowTissue oxygenationCheckerboard stimulationRest epochsBrain activationHemodynamic response functionHuman brainBrainRemote sensingNovel photonic methodPhysiological processesAcoustic vibrationsTemporal vibrationsTemporal-spatial analysisPhotonic sensing
2018
Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment
Fertuck EA, Grinband J, Mann JJ, Hirsch J, Ochsner K, Pilkonis P, Erbe J, Stanley B. Trustworthiness appraisal deficits in borderline personality disorder are associated with prefrontal cortex, not amygdala, impairment. NeuroImage Clinical 2018, 21: 101616. PMID: 30639176, PMCID: PMC6411618, DOI: 10.1016/j.nicl.2018.101616.Peer-Reviewed Original ResearchFunctional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation
Galgano J, Pantazatos S, Allen K, Yanagihara T, Hirsch J. Functional connectivity of PAG with core limbic system and laryngeal cortico-motor structures during human phonation. Brain Research 2018, 1707: 184-189. PMID: 30500402, PMCID: PMC7434632, DOI: 10.1016/j.brainres.2018.11.040.Peer-Reviewed Original ResearchConceptsPeriaqueductal gray regionPsychophysiological interaction analysisFunctional connectivityDiffusion tensor imaging (DTI) analysisTrend-level evidenceNeural mechanismsBilateral auditory corticesGreater functional connectivityAmygdala couplingWhole-brain resultsDorsomedial prefrontal cortexLimbic systemMotor areaAmygdala clustersAuditory cortexLaryngeal musculatureHealthy adultsPrefrontal cortexNeuroimaging studiesNeural activityVoice disordersStructural connectivityGray regionCortexMovement paradigmCommunication of emotion via drumming: dual-brain imaging with functional near-infrared spectroscopy
Rojiani R, Zhang X, Noah A, Hirsch J. Communication of emotion via drumming: dual-brain imaging with functional near-infrared spectroscopy. Social Cognitive And Affective Neuroscience 2018, 13: 1047-1057. PMID: 30215809, PMCID: PMC6204489, DOI: 10.1093/scan/nsy076.Peer-Reviewed Original ResearchConceptsInternational Affective Picture SystemCommunication of emotionsTemporoparietal junction (TPJ) activationExpression of emotionsSocial neuroscienceNeuroimaging paradigmEmotional contentRight TPJHigh arousalPicture SystemValence measuresNeural responsesNonverbal communicationEmotionsNatural communicationNeural activityCommunication modalitiesJunction activationHuman interactionUnderstudied topicDrummingHemodynamic signalsEffective clinical approachContrast comparisonsTPJA cross-brain neural mechanism for human-to-human verbal communication
Hirsch J, Noah J, Zhang X, Dravida S, Ono Y. A cross-brain neural mechanism for human-to-human verbal communication. Social Cognitive And Affective Neuroscience 2018, 13: 907-920. PMID: 30137601, PMCID: PMC6137318, DOI: 10.1093/scan/nsy070.Peer-Reviewed Original ResearchConceptsSuperior temporal gyrusInteractive brain hypothesisNeural mechanismsSocial interactionBrain hypothesisCanonical language areasHuman verbal communicationNon-interactive conditionDynamic social interactionsObject NamingSocial cuesInterpersonal informationBrain substratesDescription taskTemporal gyrusBroca's areaLanguage areasWernicke's areaNeural activitySubcentral areaVerbal communicationNatural settingsTheoretical frameworkGeneral theoretical frameworkDeoxyhemoglobin signalThe present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience
Pinti P, Tachtsidis I, Hamilton A, Hirsch J, Aichelburg C, Gilbert S, Burgess PW. The present and future use of functional near‐infrared spectroscopy (fNIRS) for cognitive neuroscience. Annals Of The New York Academy Of Sciences 2018, 1464: 5-29. PMID: 30085354, PMCID: PMC6367070, DOI: 10.1111/nyas.13948.Peer-Reviewed Original ResearchConceptsCognitive neuroscienceSocial cognitive neuroscienceCognitive neuroscience researchFunctional magnetic resonance imagingElectroencephalography/magnetoencephalographyPotential of fNIRSNaturalistic environmentNeuroscience researchNeuroscienceNeuroimaging modalitiesBodily movementParticipant populationExperimental settingsMagnetic resonance imagingFNIRSMagnetoencephalographyResonance imagingParticular focusResearch
2017
Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact
Hirsch J, Zhang X, Noah JA, Ono Y. Frontal temporal and parietal systems synchronize within and across brains during live eye-to-eye contact. NeuroImage 2017, 157: 314-330. PMID: 28619652, PMCID: PMC5863547, DOI: 10.1016/j.neuroimage.2017.06.018.Peer-Reviewed Original ResearchConceptsEye contactInterpersonal interactionsSupplementary motor cortexSpecificity hypothesisFrontal clusterSubcentral areaLeft superior temporal gyrusInteractive brain hypothesisTwo-person neuroscienceLimited head motionSuperior temporal gyrusTwo-person interactionsConventional neuroimaging methodsNeural correlatesSocial cuesNeural processesBrain hypothesisNeural mechanismsNeural responsesParietal systemSupramarginal gyrusMutual gazeSynchrony hypothesisLanguage functionTemporal gyrusNeural correlates of conflict between gestures and words: A domain-specific role for a temporal-parietal complex
Noah JA, Dravida S, Zhang X, Yahil S, Hirsch J. Neural correlates of conflict between gestures and words: A domain-specific role for a temporal-parietal complex. PLOS ONE 2017, 12: e0173525. PMID: 28278240, PMCID: PMC5344449, DOI: 10.1371/journal.pone.0173525.Peer-Reviewed Original ResearchConceptsTemporal-parietal junctionDorsolateral prefrontal cortexRight temporal-parietal junctionRight dorsolateral prefrontal cortexLeft dorsolateral prefrontal cortexSuperior temporal gyrusColor taskConflict taskIncongruent trialsSocial cuesGesture tasksSupramarginal gyrusBehavioral interference effectDomain-general mechanismsUnderlying neural processesReceptive language areasHuman social behaviorAuditory association cortexDomain-specific rolesFrontal eye fieldConflict processing mechanismCongruent trialsGestural cuesNeural correlatesNeural processes
2015
Motor learning and modulation of prefrontal cortex: an fNIRS assessment
Ono Y, Noah JA, Zhang X, Nomoto Y, Suzuki T, Shimada S, Tachibana A, Bronner S, Hirsch J. Motor learning and modulation of prefrontal cortex: an fNIRS assessment. Journal Of Neural Engineering 2015, 12: 066004. PMID: 26401727, DOI: 10.1088/1741-2560/12/6/066004.Peer-Reviewed Original ResearchConceptsDance video gameHemodynamic responsePrefrontal cortexMotor tasksMotor learningMotor performanceSpecific rehabilitation programPrefrontal hemodynamic responsesBaseline patternsHealthy young adultsTraining-induced changesComplex motor tasksRehabilitation programYoung adultsRegression analysisCortexRegression modelsAuditory cuesNovice playersSensitive indicatorResponseParticipantsGreater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings
Geliebter A, Benson L, Pantazatos SP, Hirsch J, Carnell S. Greater anterior cingulate activation and connectivity in response to visual and auditory high-calorie food cues in binge eating: Preliminary findings. Appetite 2015, 96: 195-202. PMID: 26275334, PMCID: PMC4684801, DOI: 10.1016/j.appet.2015.08.009.Peer-Reviewed Original ResearchConceptsDorsal anterior cingulate cortexHigh-calorie food cuesNon-BE groupFood cuesNeural responsesPsychophysiologic interactionsOrbitofrontal cortexFunctional connectivityGreater functional connectivityRegional brain activationAnterior cingulate activationHigh energy density foodsAnterior cingulate cortexLow-ED foodsAuditory cuesFMRI scanningActivation differencesBrain activationCingulate activationMore activationSupramarginal gyrusNeuroimaging studiesBE groupObese individualsCingulate cortex