2024
Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact
Zhang X, Noah J, Singh R, McPartland J, Hirsch J. Support vector machine prediction of individual Autism Diagnostic Observation Schedule (ADOS) scores based on neural responses during live eye-to-eye contact. Scientific Reports 2024, 14: 3232. PMID: 38332184, PMCID: PMC10853508, DOI: 10.1038/s41598-024-53942-z.Peer-Reviewed Original ResearchConceptsAutism Diagnostic Observation ScheduleAutism spectrum disorderAutism Diagnostic Observation Schedule scoresEye-to-eye contactSocial difficultiesNeural processesNeural responsesObservation ScheduleSymptoms of autism spectrum disorderBehavioural symptoms of autism spectrum disorderNeural activity patternsLive interaction paradigmTD groupSupport vector machineNeural mechanismsSymptom severityADOS scoresBehavioral symptomsSpectrum disorderASD diagnosisNeural dataActivity patternsAutismClassification methodMultivariate classification methods
2015
A pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder
Talati A, Pantazatos SP, Hirsch J, Schneier F. A pilot study of gray matter volume changes associated with paroxetine treatment and response in social anxiety disorder. Psychiatry Research 2015, 231: 279-285. PMID: 25659476, PMCID: PMC4363180, DOI: 10.1016/j.pscychresns.2015.01.008.Peer-Reviewed Original ResearchConceptsParoxetine treatmentSignificant gray matter reductionsGray matter volume changesAnxiety disordersNeuro-anatomical changesGray matter reductionsSocial anxiety disorderClinical responseLiebowitz Social Anxiety ScaleSymptom improvementRight thalamusVBM8 toolboxLeft thalamusSuccessful treatmentWeek 8Bilateral caudateControl groupGray matterDSM-IVSymptom severityLongitudinal changesPilot study
2013
Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment
Pantazatos SP, Talati A, Schneier FR, Hirsch J. Reduced Anterior Temporal and Hippocampal Functional Connectivity During Face Processing Discriminates Individuals with Social Anxiety Disorder from Healthy Controls and Panic Disorder, and Increases Following Treatment. Neuropsychopharmacology 2013, 39: 425-434. PMID: 24084831, PMCID: PMC3870777, DOI: 10.1038/npp.2013.211.Peer-Reviewed Original ResearchConceptsSocial anxiety disorderFunctional connectivityAnxiety disordersFace perceptionTemporal poleFunctional magnetic resonance imaging studyPanic disorderSpecific anxiety disordersIndependent replication sampleHippocampal functional connectivityMagnetic resonance imaging studyFace processingPerceptual tasksResonance imaging studyBrain activationSAD diagnosisReplication sampleHIGH-SADSAD samplesSimilar tasksDisorder-specific biomarkersFC featuresSymptom severityAnterior temporalPerception