2024
A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals
Konstantinidou P, Loubalova Z, Ahrend F, Friman A, Almeida M, Poulet A, Horvat F, Wang Y, Losert W, Lorenzi H, Svoboda P, Miska E, van Wolfswinkel J, Haase A. A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals. Cell Reports 2024, 43: 114777. PMID: 39302833, DOI: 10.1016/j.celrep.2024.114777.Peer-Reviewed Original ResearchPIWI-interacting RNAsPiwi-interacting RNA clustersPiRNA clustersPiRNA biologySilencing mobile genetic elementsGenomic piRNA clustersSingle-stranded precursorsMobile genetic elementsSafeguarding genome integrityGerm cell biologySpecies-specific variationGenome invadersTranscriptional readthroughTransposon insertionGenetic elementsGenome integrityRetroviral invasionMolecular mechanismsCell biologyRNAMammalsSpeciesBiologyTransposonReadthrough
2014
Whole-Body Acoel Regeneration Is Controlled by Wnt and Bmp-Admp Signaling
Srivastava M, Mazza-Curll K, van Wolfswinkel J, Reddien P. Whole-Body Acoel Regeneration Is Controlled by Wnt and Bmp-Admp Signaling. Current Biology 2014, 24: 1107-1113. PMID: 24768051, DOI: 10.1016/j.cub.2014.03.042.Peer-Reviewed Original ResearchConceptsWhole-body regenerationMolecular mechanismsLast common ancestorEarly branching positionDorsal-ventral axisYears of evolutionEnigmatic phylumBilaterian evolutionMolecular resourcesUnderlying molecular mechanismsSystemic RNAiAccessible embryosCommon ancestorHofsteniaPhylogenetic analysisVentral cellsAcoelsMolecular studiesTranscriptomePhylaRNAiPlanariansAncestorBranching positionModel system