Featured Publications
Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney
Chaurasia R, Salovey A, Guo X, Desir G, Vinetz JM. Vaccination With Leptospira interrogans PF07598 Gene Family-Encoded Virulence Modifying Proteins Protects Mice From Severe Leptospirosis and Reduces Bacterial Load in the Liver and Kidney. Frontiers In Cellular And Infection Microbiology 2022, 12: 926994. PMID: 35837473, PMCID: PMC9274288, DOI: 10.3389/fcimb.2022.926994.Peer-Reviewed Original ResearchConceptsLethal challenge infectionChallenge infectionBacterial loadC3H/HeJ miceKey target organClinical pathogenesisSevere leptospirosisOrgan infectionProtein immunizationHeJ miceSerovar CanicolaTarget organsAnimal modelsLeptospirosis pathogenesisCellular pathogenesisMicePathogenesisInfectionLeptospira interrogansVirulence factorsModifying proteinsImmunizationKidneyLeptospirosisLiver
2016
What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira
Fouts DE, Matthias MA, Adhikarla H, Adler B, Amorim-Santos L, Berg DE, Bulach D, Buschiazzo A, Chang YF, Galloway RL, Haake DA, Haft DH, Hartskeerl R, Ko AI, Levett PN, Matsunaga J, Mechaly AE, Monk JM, Nascimento AL, Nelson KE, Palsson B, Peacock SJ, Picardeau M, Ricaldi JN, Thaipandungpanit J, Wunder EA, Yang XF, Zhang JJ, Vinetz JM. What Makes a Bacterial Species Pathogenic?:Comparative Genomic Analysis of the Genus Leptospira. PLOS Neglected Tropical Diseases 2016, 10: e0004403. PMID: 26890609, PMCID: PMC4758666, DOI: 10.1371/journal.pntd.0004403.Peer-Reviewed Original ResearchConceptsGenes/gene familiesProtein secretion systemComparative genomic analysisSignal peptide motifsCRISPR/Cas systemComputational biology analysisMammalian host adaptationBacterial pathogensWhole-genome analysisSialic acid biosynthesisLeptospira speciesEvolutionary relatednessSaprophytic Leptospira speciesGene familyMetabolic reconstructionGenomic comparisonSecretion motifBacterial virulence factorsHost adaptationSecretion systemGenome analysisAcid biosynthesisGenomic analysisNew insightsMammalian hosts
2001
Disruption of Plasmodium falciparumChitinase Markedly Impairs Parasite Invasion of Mosquito Midgut
Tsai Y, Hayward R, Langer R, Fidock D, Vinetz J. Disruption of Plasmodium falciparumChitinase Markedly Impairs Parasite Invasion of Mosquito Midgut. Infection And Immunity 2001, 69: 4048-4054. PMID: 11349075, PMCID: PMC98468, DOI: 10.1128/iai.69.6.4048-4054.2001.Peer-Reviewed Original ResearchConceptsMosquito midgutChitinase geneAvian malaria parasite Plasmodium gallinaceumMalaria parasite Plasmodium gallinaceumMutant ookinetesGenome databasePeritrophic matrixGene productsIntracellular traffickingBp upstreamOokinete invasionStop codonParasite invasionChitinolytic activityPfCHT1MidgutOokinetesOokinete formationGenesConfocal microscopyBlood mealApical endPlasmodium gallinaceumP. falciparumInvasion