2024
Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax
Cao Y, Hayashi C, Araujo M, Tripathi A, Andrade A, Medeiros J, Vinetz J, Kumar N. Evaluation of combination vaccines targeting transmission of Plasmodium falciparum and P. vivax. Vaccine 2024, 42: 126140. PMID: 39033079, PMCID: PMC11338703, DOI: 10.1016/j.vaccine.2024.07.041.Peer-Reviewed Original ResearchDirect membrane feeding assaysTransmission-reducing activityStandard membrane feeding assayMembrane feeding assaysP. vivaxDNA vaccineP. falciparumPlasmodium falciparumTransmission of Plasmodium falciparumAntibody responseDNA vaccine platformP. vivax accountsGlobal malaria burdenTransmission-blocking activityTransmission of malariaCombination of DNA vaccineIn vivo electroporationCombined DNA vaccineMalaria burdenMalaria transmissionTransmission-blockingAssess immunogenicityVaccine platformClinical studiesCombination groupTransmission-reducing and -enhancing monoclonal antibodies against Plasmodium vivax gamete surface protein Pvs48/45
Bansal G, da Silva Araujo M, Cao Y, Shaffer E, Araujo J, Medeiros J, Hayashi C, Vinetz J, Kumar N. Transmission-reducing and -enhancing monoclonal antibodies against Plasmodium vivax gamete surface protein Pvs48/45. Infection And Immunity 2024, 92: e00374-23. PMID: 38289124, PMCID: PMC10929423, DOI: 10.1128/iai.00374-23.Peer-Reviewed Original ResearchDirect membrane feeding assaysTransmission-blocking vaccinesTransmission-blocking vaccine developmentMalaria transmission-blocking vaccineBlocked oocyst developmentInfectivity of gametocytesMale gamete fertilityMonoclonal antibodiesMembrane feeding assaysTransmission-blocking activityPvs48/45Activity of antibodiesNon-overlapping epitopesOocyst developmentPotential vaccine candidatesIndividual MAbsVaccine candidatesEffective immunogensChallenge modelMAbAntibodiesGametocytesEpitopesRecombinant fragmentsEnhanced activity
2023
Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi
Andrade A, Santos N, Bastos A, Pontual J, Araújo J, Silva A, Martinez L, Lima A, Aguiar A, Teles C, Medeiros J, Pereira D, Vinetz J, Gazzinelli R, Araújo M. Transmission-blocking activity of antimalarials for Plasmodium vivax malaria in Anopheles darlingi. PLOS Neglected Tropical Diseases 2023, 17: e0011425. PMID: 37327209, PMCID: PMC10310017, DOI: 10.1371/journal.pntd.0011425.Peer-Reviewed Original ResearchConceptsDensity of gametocytesTransmission-blocking efficacyPlasmodium vivax malariaTransmission-blocking activityImportant infectious diseasesOne-doseVivax malariaP. vivaxMosquito infectionPlasmodium vivaxTreatment groupsPatient's bloodGametocyte productionMalaria transmissionInfectious diseasesGenus PlasmodiumMalariaTreatmentChloroquinePrimaquineVivaxBloodDirect membraneBiological characteristicsMosquitoes