2011
When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study.
Cain L, Logan R, Robins J, Sterne J, Sabin C, Bansi L, Justice A, Goulet J, van Sighem A, de Wolf F, Bucher H, von Wyl V, Esteve A, Casabona J, del Amo J, Moreno S, Seng R, Meyer L, Perez-Hoyos S, Muga R, Lodi S, Lanoy E, Costagliola D, Hernan M. When to initiate combined antiretroviral therapy to reduce mortality and AIDS-defining illness in HIV-infected persons in developed countries: an observational study. Annals Of Internal Medicine 2011, 154: 509-15. PMID: 21502648, PMCID: PMC3610527, DOI: 10.7326/0003-4819-154-8-201104190-00001.Peer-Reviewed Original ResearchConceptsCD4 cell countCombined end pointHazard ratioCell countCells/LAntiretroviral therapyCells/L.CD4 cell count thresholdBaseline CD4 cell countEnd pointVeterans Health Administration systemInitiation of cARTThreshold CD4 countCorresponding hazard ratiosMortality hazard ratioAIDS-free survivalProspective observational dataHIV-CAUSAL CollaborationMost clinical guidelinesHealth Administration systemUse of CD4Marginal structural modelsCell count thresholdCART initiationDynamic marginal structural models
2000
HIV as a chronic disease: Implications for long-term care at an AIDS-dedicated skilled nursing facility
Selwyn P, Goulet J, Molde S, Constantino J, Fennie K, Wetherill P, Gaughan D, Brett-Smith H, Kennedy C. HIV as a chronic disease: Implications for long-term care at an AIDS-dedicated skilled nursing facility. Journal Of Urban Health 2000, 77: 187-203. PMID: 10856000, PMCID: PMC3456125, DOI: 10.1007/bf02390530.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultChronic DiseaseConnecticutFemaleHumansLong-Term CareMaleMedicaidOrganizations, NonprofitOutcome Assessment, Health CarePalliative CareSkilled Nursing FacilitiesUnited StatesConceptsSkilled nursing facilitiesLong-term careNursing facilitiesPsychiatric illnessNeurologic diseaseTerminal careChronic disease phaseComparison of admissionMedian Karnofsky scoreLong-term care facilitiesCurrent antiretroviral therapyLength of stayInjection drug usersYear of admissionSerious neurologic diseaseAcute medical treatmentLevel of careAdmission medicationsMedian CD4Advanced diseaseAntiretroviral therapyImportant service needsKarnofsky scoreChart reviewImmunodeficiency syndrome