2024
Neuroethics, Covert Consciousness, and Disability Rights: What Happens When Artificial Intelligence Meets Cognitive Motor Dissociation?
Fins J, Shulman K. Neuroethics, Covert Consciousness, and Disability Rights: What Happens When Artificial Intelligence Meets Cognitive Motor Dissociation? Journal Of Cognitive Neuroscience 2024, 36: 1667-1674. PMID: 38579252, DOI: 10.1162/jocn_a_02157.Peer-Reviewed Original ResearchConceptsCognitive motor dissociationCovert consciousnessBrain injuryRight-to-die movementOvert behaviorEEG studiesCognitive activityMotor dissociationSevere brain injuryNormative challengesModes of assessmentDisability biasClinical practiceNormative reasonsGenerate speechEthical challengesArtificial intelligenceAlphabet soupAnticipatory governanceTranslational research
2023
Minding Brain Injury, Consciousness, and Ethics: Discourse and Deliberations.
Fins J, Giordano J. Minding Brain Injury, Consciousness, and Ethics: Discourse and Deliberations. Kennedy Institute Of Ethics Journal 2023, 33: 227-248. PMID: 38588134, DOI: 10.1353/ken.2023.a917928.Peer-Reviewed Original ResearchCognitive Motor Dissociation: Gap Analysis and Future Directions
Claassen J, Kondziella D, Alkhachroum A, Diringer M, Edlow B, Fins J, Gosseries O, Hannawi Y, Rohaut B, Schnakers C, Stevens R, Thibaut A, Monti M. Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care 2023, 40: 81-98. PMID: 37349602, DOI: 10.1007/s12028-023-01769-3.Peer-Reviewed Original ResearchMeSH KeywordsBrainBrain InjuriesConsciousnessConsciousness DisordersHumansMagnetic Resonance ImagingConceptsMethodsThe Neurocritical Care SocietyCognitive motor dissociationNeurocritical Care SocietyDisorders of consciousnessCare SocietyFunctional magnetic resonance imagingHealth care personnelEducational gapPotential prognostic relevanceCaregiver accountsManagement of patientsIdentification of patientsPatient experienceCare personnelInternational group of expertsUnmet needsMagnetic resonance imagingPrognostic significanceKnowledge gapsMethodological variablesTreatment trialsEpidemiological dataGroup of expertsClinical practiceLarge-scale implementationPhysician attitudes about disorders of consciousness: Good facts make for good ethics
Fins J. Physician attitudes about disorders of consciousness: Good facts make for good ethics. Developmental Medicine & Child Neurology 2023, 65: 1549-1550. PMID: 37058590, PMCID: PMC10576007, DOI: 10.1111/dmcn.15619.Peer-Reviewed Original ResearchEthics Along the Continuum of Research Involving Persons with Disorders of Consciousness
Lewis A, Young M, Rohaut B, Jox R, Claassen J, Creutzfeldt C, Illes J, Kirschen M, Trevick S, Fins J. Ethics Along the Continuum of Research Involving Persons with Disorders of Consciousness. Neurocritical Care 2023, 39: 565-577. PMID: 36977963, PMCID: PMC11023737, DOI: 10.1007/s12028-023-01708-2.Peer-Reviewed Original ResearchConceptsTranslation of researchDisclosure of resultsDisorders of consciousnessContinuum of researchEthical considerationsNeuropalliative careEthics Working GroupInterpretation of outcomesLegally authorized representativeCommunication of resultsComparison of risksStudy designCarePromote recoveryInvolved personsInclusion of minoritiesExclusion criteriaNeurocritical careWorking GroupPersonsInformal reviewOutcomesAwarenessParticipation rightsData protection
2022
Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness
Mainali S, Aiyagari V, Alexander S, Bodien Y, Boerwinkle V, Boly M, Brown E, Brown J, Claassen J, Edlow BL, Fink EL, Fins JJ, Foreman B, Frontera J, Geocadin RG, Giacino J, Gilmore EJ, Gosseries O, Hammond F, Helbok R, Claude Hemphill J, Hirsch K, Kim K, Laureys S, Lewis A, Ling G, Livesay SL, McCredie V, McNett M, Menon D, Molteni E, Olson D, O’Phelan K, Park S, Polizzotto L, Javier Provencio J, Puybasset L, Venkatasubba Rao CP, Robertson C, Rohaut B, Rubin M, Sharshar T, Shutter L, Sampaio Silva G, Smith W, Stevens RD, Thibaut A, Vespa P, Wagner AK, Ziai WC, Zink E, I Suarez J. Proceedings of the Second Curing Coma Campaign NIH Symposium: Challenging the Future of Research for Coma and Disorders of Consciousness. Neurocritical Care 2022, 37: 326-350. PMID: 35534661, PMCID: PMC9283342, DOI: 10.1007/s12028-022-01505-3.Peer-Reviewed Original ResearchEthics and the 2018 Practice Guideline on Disorders of Consciousness
Peterson A, Young M, Fins J. Ethics and the 2018 Practice Guideline on Disorders of Consciousness. Neurology 2022, 98: 712-718. PMID: 35277446, PMCID: PMC9071367, DOI: 10.1212/wnl.0000000000200301.Peer-Reviewed Original ResearchConsciousness, Conflations, and Disability Rights: Denials of Care for Children in the "Minimally Conscious State".
Fins J. Consciousness, Conflations, and Disability Rights: Denials of Care for Children in the "Minimally Conscious State". The Journal Of Law, Medicine & Ethics 2022, 50: 181-183. PMID: 35243988, DOI: 10.1017/jme.2022.22.Peer-Reviewed Original Research
2021
Brain Organoids and Consciousness: Late Night Musings Inspired by Lewis Thomas
Fins J. Brain Organoids and Consciousness: Late Night Musings Inspired by Lewis Thomas. Cambridge Quarterly Of Healthcare Ethics 2021, 30: 557-560. PMID: 34702402, DOI: 10.1017/s0963180121000037.Peer-Reviewed Original ResearchEmpiricism and Rights Justify the Allocation of Health Care Resources to Persons with Disorders of Consciousness
Giacino J, Bodien Y, Zuckerman D, Henderson J, Schiff N, Fins J. Empiricism and Rights Justify the Allocation of Health Care Resources to Persons with Disorders of Consciousness. AJOB Neuroscience 2021, 12: 169-171. PMID: 33960891, DOI: 10.1080/21507740.2021.1904055.Peer-Reviewed Original Research
2020
Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit
Edlow B, Barra M, Zhou D, Foulkes A, Snider S, Threlkeld Z, Chakravarty S, Kirsch J, Chan S, Meisler S, Bleck T, Fins J, Giacino J, Hochberg L, Solt K, Brown E, Bodien Y. Personalized Connectome Mapping to Guide Targeted Therapy and Promote Recovery of Consciousness in the Intensive Care Unit. Neurocritical Care 2020, 33: 364-375. PMID: 32794142, PMCID: PMC8336723, DOI: 10.1007/s12028-020-01062-7.Peer-Reviewed Original ResearchMeSH KeywordsBrain InjuriesBrain Injuries, TraumaticConnectomeConsciousnessHumansIntensive Care UnitsTreatment OutcomeConceptsIntensive care unitPromote recovery of consciousnessRecovery of consciousnessIntravenous methylphenidateEarly recovery of consciousnessPromote early recoveryPhase 2aDrug-related adverse eventsCare unitAscending arousal networkEscalating daily dosesHighest tolerated doseAcute severe traumatic brain injuryDose-finding studyOutcome measuresBrain injurySerum half-lifeMaximal serum concentrationPrimary outcome measureWithdrawal of life-sustaining therapyDrug’s pharmacodynamic propertiesSecondary outcome measuresMagnetic resonance imagingOpen-labelPharmacodynamic criteriaTHE JEREMIAH METZGER LECTURE: DISORDERS OF CONSCIOUSNESS AND THE NORMATIVE UNCERTAINTY OF AN EMERGING NOSOLOGY.
Fins J. THE JEREMIAH METZGER LECTURE: DISORDERS OF CONSCIOUSNESS AND THE NORMATIVE UNCERTAINTY OF AN EMERGING NOSOLOGY. Transactions Of The American Clinical And Climatological Association 2020, 131: 235-269. PMID: 32675864, PMCID: PMC7358498.Peer-Reviewed Original Research
2019
When No One Notices: Disorders of Consciousness and the Chronic Vegetative State
Fins J. When No One Notices: Disorders of Consciousness and the Chronic Vegetative State. The Hastings Center Report 2019, 49: 14-17. PMID: 31429953, DOI: 10.1002/hast.1030.Peer-Reviewed Original ResearchConceptsNational Institute on DisabilityMulti-Society Task Force ReportDisorders of consciousnessAmerican Academy of NeurologyComprehensive evidence-based reviewEvidence-based reviewRehabilitation researchRehabilitation medicineVegetative stateChronic vegetative stateHealthcare facilitiesTask Force ReportPractice guidelinesIndependent livingPersistent vegetative stateAmerican CollegeAmerican AcademyMisdiagnosis of patientsLevel of consciousnessPermanent vegetative stateForce ReportDiagnostic categoriesPatientsAmericanGuidelinesAuthor response: Ethical, palliative, and policy considerations in disorders of consciousness.
Fins J, Bernat J. Author response: Ethical, palliative, and policy considerations in disorders of consciousness. Neurology 2019, 92: 974. PMID: 31085728, DOI: 10.1212/wnl.0000000000007519.Peer-Reviewed Original ResearchOnce and Future Clinical Neuroethics: A History of What Was and What Might Be.
Fins J. Once and Future Clinical Neuroethics: A History of What Was and What Might Be. The Journal Of Clinical Ethics 2019, 30: 27-34. PMID: 30896441, DOI: 10.1086/jce2019301027.Peer-Reviewed Original ResearchMeSH KeywordsBioethicsConsciousnessHistory, 20th CenturyHumansNeurosciencesPersistent Vegetative State
2018
Assessment of Covert Consciousness in the Intensive Care Unit
Edlow B, Fins J. Assessment of Covert Consciousness in the Intensive Care Unit. Journal Of Head Trauma Rehabilitation 2018, 33: 424-434. PMID: 30395042, PMCID: PMC6317885, DOI: 10.1097/htr.0000000000000448.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTraumatic brain injuryAcute severe traumatic brain injurySevere traumatic brain injuryIntensive care unitCovert consciousnessEthical challengesIntensive care unit patientsTask-based functional magnetic resonance imagingTask-based fMRILife-sustaining therapyWithdrawal of life-sustaining therapyCare unitEthical frameworkBehavioral assessmentCritically ill patientsEvaluation normsMagnetic resonance imagingConsciousnessBrain injuryGoals of careClinical scenariosIll patientsRecovered consciousnessTreatment decisionsConstructive Disappointment and Disbelief: Building a Career in Neuroethics
Fins J. Constructive Disappointment and Disbelief: Building a Career in Neuroethics. Cambridge Quarterly Of Healthcare Ethics 2018, 27: 544-553. PMID: 30198463, DOI: 10.1017/s0963180118000063.Peer-Reviewed Original Research
2016
Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research
Fins J. Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research. The AMA Journal Of Ethic 2016, 18: 1182. PMID: 28009244, DOI: 10.1001/journalofethics.2016.18.12.ecas2-1612.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMinimally conscious stateEnd-of-life careConscious stateEnd-of-lifeEthical obligationNeuropalliative careDeep brain stimulationPatientsBrain statesClinicians' ethical obligationsClinical practiceCivil rightsConsciousnessScientific advancesDiagnostic discernmentClinical researchBrain stimulationResearch decisionsDisordersFunctional communicationInvestigate useCareNeuroethicsPainThe historical origins of the vegetative state: Received wisdom and the utility of the text
Adams Z, Fins J. The historical origins of the vegetative state: Received wisdom and the utility of the text. Journal Of The History Of The Neurosciences 2016, 26: 140-153. PMID: 27295518, DOI: 10.1080/0964704x.2016.1184074.Peer-Reviewed Original ResearchConceptsPersistent vegetative stateHistorical originsEarly-twentieth centuriesClassical scholarshipOriginal GreekAristotle’s treatisesAristotle’s definitionXavier BichatVegetative stateTheory of MindReception studiesMedical nosologyAristotleReceived wisdomPhrasesBichatAntiquityNineteenthGreekTreatisesCenturyEtymologyClassicsOriginScholarship
2011
Neuroethics, neuroimaging, and disorders of consciousness: promise or peril?
Fins J. Neuroethics, neuroimaging, and disorders of consciousness: promise or peril? Transactions Of The American Clinical And Climatological Association 2011, 122: 336-46. PMID: 21686236, PMCID: PMC3116331.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDisorders of consciousnessPositron emission tomographyBehavior-based assessmentsMinimally conscious stateNeuroimaging dataNeuroimaging toolsBrain statesBrain injuryMagnetic resonance imagingNeuroimagingEmission tomographyConscious stateDisordersBrainResonance imagingNeuroimaging applicationsConsciousnessDiagnostic dilemmaTherapeutic useCommunication vectorNeuroethics