2024
Cognitive Motor Dissociation in Disorders of Consciousness
Bodien Y, Allanson J, Cardone P, Bonhomme A, Carmona J, Chatelle C, Chennu S, Conte M, Dehaene S, Finoia P, Heinonen G, Hersh J, Kamau E, Lawrence P, Lupson V, Meydan A, Rohaut B, Sanders W, Sitt J, Soddu A, Valente M, Velazquez A, Voss H, Vrosgou A, Claassen J, Edlow B, Fins J, Gosseries O, Laureys S, Menon D, Naccache L, Owen A, Pickard J, Stamatakis E, Thibaut A, Victor J, Giacino J, Bagiella E, Schiff N. Cognitive Motor Dissociation in Disorders of Consciousness. New England Journal Of Medicine 2024, 391: 598-608. PMID: 39141852, DOI: 10.1056/nejmoa2400645.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingTask-based fMRICognitive motor dissociationDisorders of consciousnessComa Recovery Scale-RevisedCognitive tasksMotor dissociationObserved responseBrain injuryVerbal commandsBrain traumaScale-RevisedMagnetic resonance imagingDisordersBrainParticipantsEtiological factorsAssociated with younger ageElectroencephalographyCohort of personsResonance imagingProspective cohort studyTaskElectroencephalography dataMedian age
2023
Standards and Ethics Issues in the Determination of Death: A Position Paper From the American College of Physicians.
DeCamp M, Prager K, Opole I, Deep N, Callister T, Abraham G, Bornstein S, Bruera E, Burnett J, Carney J, Collamer A, Cooney T, Esbensen K, Fins J, Fuson O, Harp T, Holbrook A, Huddle T, Jung D, Levine M, Mire R, Prager K, Wallace E. Standards and Ethics Issues in the Determination of Death: A Position Paper From the American College of Physicians. Annals Of Internal Medicine 2023, 176: 1245-1250. PMID: 37665984, DOI: 10.7326/m23-1361.Peer-Reviewed Original ResearchConceptsDetermination of deathUniform Determination of Death ActDead donor ruleEthical significanceAmerican College of Physicians position paperEthical issuesPatient-physician relationshipUniform DeterminationAmerican College of PhysiciansAmerican CollegeCollege of PhysiciansBiological conceptsHealth professionalsEducational effortsSocial implicationsPosition paperMedical testsPatient deathProfessionPhysiciansHonestyIndividual patientsCommitmentAmericanControversiesCognitive Motor Dissociation: Gap Analysis and Future Directions
Claassen J, Kondziella D, Alkhachroum A, Diringer M, Edlow B, Fins J, Gosseries O, Hannawi Y, Rohaut B, Schnakers C, Stevens R, Thibaut A, Monti M. Cognitive Motor Dissociation: Gap Analysis and Future Directions. Neurocritical Care 2023, 40: 81-98. PMID: 37349602, DOI: 10.1007/s12028-023-01769-3.Peer-Reviewed Original ResearchConceptsMethodsThe Neurocritical Care SocietyCognitive motor dissociationNeurocritical Care SocietyDisorders of consciousnessCare SocietyFunctional magnetic resonance imagingHealth care personnelEducational gapPotential prognostic relevanceCaregiver accountsManagement of patientsIdentification of patientsPatient experienceCare personnelInternational group of expertsUnmet needsMagnetic resonance imagingPrognostic significanceKnowledge gapsMethodological variablesTreatment trialsEpidemiological dataGroup of expertsClinical practiceLarge-scale implementation
2022
Brain Device Research and the Underappreciated Role of Care Partners before, during, and Post-Trial
Merner A, Fins J, Lázaro-Muñoz G. Brain Device Research and the Underappreciated Role of Care Partners before, during, and Post-Trial. AJOB Neuroscience 2022, 13: 236-239. PMID: 36272159, PMCID: PMC9639607, DOI: 10.1080/21507740.2022.2126548.Peer-Reviewed Original Research
2021
Brain Organoids and Consciousness: Late Night Musings Inspired by Lewis Thomas
Fins J. Brain Organoids and Consciousness: Late Night Musings Inspired by Lewis Thomas. Cambridge Quarterly Of Healthcare Ethics 2021, 30: 557-560. PMID: 34702402, DOI: 10.1017/s0963180121000037.Peer-Reviewed Original Research
2016
Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research
Fins J. Neuroethics and Disorders of Consciousness: Discerning Brain States in Clinical Practice and Research. The AMA Journal Of Ethic 2016, 18: 1182. PMID: 28009244, DOI: 10.1001/journalofethics.2016.18.12.ecas2-1612.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessMinimally conscious stateEnd-of-life careConscious stateEnd-of-lifeEthical obligationNeuropalliative careDeep brain stimulationPatientsBrain statesClinicians' ethical obligationsClinical practiceCivil rightsConsciousnessScientific advancesDiagnostic discernmentClinical researchBrain stimulationResearch decisionsDisordersFunctional communicationInvestigate useCareNeuroethicsPainBrain death and disorders of consciousness
Schiff N, Fins J. Brain death and disorders of consciousness. Current Biology 2016, 26: r572-r576. PMID: 27404252, DOI: 10.1016/j.cub.2016.02.027.Peer-Reviewed Original ResearchConceptsDisorders of consciousnessBrain-dead patientsBrain deathVegetative stateCognitive motor dissociationScientific knowledgeCognitive functionMinimally conscious stateNon-medical specialistsSocietal contextBrain statesConsciousnessConscious stateMotor dissociationBrainDisordersDead patientsConceptual frameworkLack of sustainabilityHigher levelsFutilityParadoxDistinction
2015
Nanotechnology, neuromodulation & the immune response: Discourse, materiality & ethics
Fins J. Nanotechnology, neuromodulation & the immune response: Discourse, materiality & ethics. Biomedical Microdevices 2015, 17: 28. PMID: 25681046, DOI: 10.1007/s10544-015-9934-0.Peer-Reviewed Original Research
2011
Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury
Bardin J, Fins J, Katz D, Hersh J, Heier L, Tabelow K, Dyke J, Ballon D, Schiff N, Voss H. Dissociations between behavioural and functional magnetic resonance imaging-based evaluations of cognitive function after brain injury. Brain 2011, 134: 769-782. PMID: 21354974, PMCID: PMC3044833, DOI: 10.1093/brain/awr005.Peer-Reviewed Original ResearchConceptsBrain-injured subjectsBlood oxygen level-dependent responsesBrain-injured patientsCognitive functionFunctional magnetic resonance imaging assessmentsEvaluation of cognitive functionFunctional neuroimaging methodsOvert behavioral responsesSeverely brain-injured patientsNeuroimaging methodsBrain functionBehavioral responsesBrain injuryMagnetic resonance imaging-based methodMotor functionControl groupBrainMagnetic resonance imaging assessmentSubjectsClinical useImaging assessmentResponseNeuroethics, neuroimaging, and disorders of consciousness: promise or peril?
Fins J. Neuroethics, neuroimaging, and disorders of consciousness: promise or peril? Transactions Of The American Clinical And Climatological Association 2011, 122: 336-46. PMID: 21686236, PMCID: PMC3116331.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingDisorders of consciousnessPositron emission tomographyBehavior-based assessmentsMinimally conscious stateNeuroimaging dataNeuroimaging toolsBrain statesBrain injuryMagnetic resonance imagingNeuroimagingEmission tomographyConscious stateDisordersBrainResonance imagingNeuroimaging applicationsConsciousnessDiagnostic dilemmaTherapeutic useCommunication vectorNeuroethics
2010
In the Blink of the Mind's Eye
Fins J, Schiff N. In the Blink of the Mind's Eye. The Hastings Center Report 2010, 40: 21-23. PMID: 20549875, DOI: 10.1353/hcr.0.0257.Peer-Reviewed Original Research
2008
Lights, Camera, Inaction? Neuroimaging and Disorders of Consciousness
Fins J, Illes J. Lights, Camera, Inaction? Neuroimaging and Disorders of Consciousness. The American Journal Of Bioethics 2008, 8: w1-w3. PMID: 18853370, DOI: 10.1080/15265160802479568.Peer-Reviewed Original ResearchAre we equal in death?
Laureys S, Fins J. Are we equal in death? Neurology 2008, 70: e14-e15. PMID: 18209196, DOI: 10.1212/01.wnl.0000303264.66049.c1.Peer-Reviewed Original Research
2007
Neuroimaging and neuroethics: clinical and policy considerations
Fins J, Shapiro Z. Neuroimaging and neuroethics: clinical and policy considerations. Current Opinion In Neurology 2007, 20: 650-654. PMID: 17992084, DOI: 10.1097/wco.0b013e3282f11f6d.Peer-Reviewed Original ResearchConceptsMinimally conscious stateMechanisms of recoveryBrain injuryConscious stateMechanisms of brain recoveryFunctional imagingDiagnostic nosologyDisorders of consciousnessNeuroimaging responsesDiagnostic categoriesSevere brain injuryPremature disseminationNeuroimagingBrain recoveryDisordersHealth policyConsciousness disorderEthical implicationsTherapeutic approachesClinical diagnosisClinical practiceCliniciansPatientsNosologyImplicationsDeep brain stimulation and cognition: moving from animal to patient
Schiff N, Fins J. Deep brain stimulation and cognition: moving from animal to patient. Current Opinion In Neurology 2007, 20: 638-642. PMID: 17992082, DOI: 10.1097/wco.0b013e3282f1c6e4.Peer-Reviewed Original ResearchConceptsCognitive functionBrain injuryDeep brain stimulationModulate cognitive functionsBrain stimulationCentral thalamic deep brain stimulationImpaired cognitive functionBehavioral improvementBrain electrical stimulationThalamic deep brain stimulationTherapeutic optionsBrainNonprogressive brain injuryArea of researchElectrical stimulationInjuryPatientsStimulationCognitionStudy design
2006
Shades of Gray: New Insights on the Vegetative State
Fins J, Schiff N. Shades of Gray: New Insights on the Vegetative State. The Hastings Center Report 2006, 36: 8-8. PMID: 17278863, DOI: 10.1353/hcr.2006.0094.Peer-Reviewed Original Research
2005
The Afterlife of Terri Schiavo
Fins J, Schiff N. The Afterlife of Terri Schiavo. The Hastings Center Report 2005, 35: 8-8. PMID: 16225295, DOI: 10.1353/hcr.2005.0038.Peer-Reviewed Original Research
2003
Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access
Fins J. Constructing an ethical stereotaxy for severe brain injury: balancing risks, benefits and access. Nature Reviews Neuroscience 2003, 4: 323-327. PMID: 12671648, DOI: 10.1038/nrn1079.Peer-Reviewed Original ResearchFrom psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research
Fins J. From psychosurgery to neuromodulation and palliation: history's lessons for the ethical conduct and regulation of neuropsychiatric research. Neurosurgery Clinics Of North America 2003, 14: 303-319. PMID: 12856496, DOI: 10.1016/s1042-3680(02)00118-3.Peer-Reviewed Original ResearchConceptsPsychiatric illnessDeep brain stimulationObsessive-compulsive disorderEra of psychosurgerySevere psychiatric illnessTreat psychiatric illnessBrain stimulationTreatment of Parkinson's diseaseModulation of consciousnessTraumatic brain injurySomatic therapiesNeuropsychiatric researchPrefrontal lobotomyBrain injuryCongressional callsPsychosurgeryParkinson's diseaseImplanted deep brain stimulationNeuromodulationIllnessHistory lessonsPsychiatristsPsychiatryLobotomyWidespread condemnation
2002
Deep Brain Stimulation for Psychiatric Disorders
Nuttin B, Gybels J, Cosyns P, Gabriels L, Meyerson B, Andréewitch S, Rasmussen S, Greenberg B, Friehs G, Rezai A, Montgomery E, Malone D, Fins J. Deep Brain Stimulation for Psychiatric Disorders. Neurosurgery 2002, 51: 519-519. PMID: 12197492, DOI: 10.1227/00006123-200208000-00044.Peer-Reviewed Original Research