Induction and detection of a human endothelial activation antigen in vivo.
Cotran RS, Gimbrone MA, Bevilacqua MP, Mendrick DL, Pober JS. Induction and detection of a human endothelial activation antigen in vivo. Journal Of Experimental Medicine 1986, 164: 661-666. PMID: 3723080, PMCID: PMC2188244, DOI: 10.1084/jem.164.2.661.Peer-Reviewed Original ResearchConceptsEndothelial activation antigenActivation antigensSequential skin biopsiesStrong positive stainingHuman umbilical vein endothelial cell culturesEndothelial cell functionLymph nodesHypersensitivity reactionsSkin biopsiesInflammatory reactionImmunoperoxidase techniqueVascular endotheliumPositive stainingEndothelial cell culturesNormal endotheliumMurine mAbsUseful markerH4/18EndotheliumAntigenCell functionSkinPathological tissuesHuman skinTissueRecombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1.
Bevilacqua MP, Pober JS, Majeau GR, Fiers W, Cotran RS, Gimbrone MA. Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 4533-4537. PMID: 3487091, PMCID: PMC323768, DOI: 10.1073/pnas.83.12.4533.Peer-Reviewed Original ResearchConceptsRecombinant tumor necrosis factorCultured human vascular endotheliumTumor necrosis factorIL-1Procoagulant activityHuman vascular endotheliumNecrosis factorInterleukin-1Vascular endotheliumTissue factor-like procoagulant activityInduction of PCANatural human interleukin-1Human recombinant tumor necrosis factorEndothelial cell damageCellular procoagulant activityEndothelial procoagulant activityRecombinant IL-1Specific neutralizing antiseraHuman interleukin-1Effects of TNFInitiation of coagulationIliac arteryMaximal dosesPCA responseSaphenous vein