2024
Improved total shoulder arthroplasty outcomes associated with semaglutide utilization in patients with type II diabetes: A promising new addition to preoperative optimization
Seddio A, Wilhelm C, Gouzoulis M, Islam W, Vasudevan R, Halperin S, Rubin L, Medvecky M, Donohue K, Grauer J. Improved total shoulder arthroplasty outcomes associated with semaglutide utilization in patients with type II diabetes: A promising new addition to preoperative optimization. JSES International 2024 DOI: 10.1016/j.jseint.2024.10.006.Peer-Reviewed Original ResearchTotal shoulder arthroplastyBody mass indexT2DM patientsElixhauser Comorbidity IndexMultivariate analysisOdds of surgical site infectionUrinary tract infectionSurgical site infectionAcute kidney injuryType II diabetes mellitusII diabetes mellitusTract infectionsSite infectionClinical benefitPreoperative optimizationCardiac eventsKidney injuryVenous thromboembolismMetformin useAdverse eventsManagement of type II diabetes mellitusMass indexDiabetes mellitusType II diabetesAdverse outcomesTotal Hip Arthroplasty in Patients Who Have Factor V Leiden: Elevated Risks Isolated to Venous Thromboembolism Events
Sanchez J, Jiang W, Dhodapkar M, Radford Z, Rubin L, Grauer J. Total Hip Arthroplasty in Patients Who Have Factor V Leiden: Elevated Risks Isolated to Venous Thromboembolism Events. The Journal Of Arthroplasty 2024, 39: 2421-2426. PMID: 38838962, DOI: 10.1016/j.arth.2024.05.083.Peer-Reviewed Original ResearchFactor V LeidenAdverse eventsChemoprophylactic agentV LeidenMultivariate analysisFactor V Leiden patientsTotal hip arthroplastyPatients to venous thromboembolismLog-rank testIncreased VTE riskVenous thromboembolic eventsElevated riskPerioperative adverse eventsPre-existing comorbiditiesAdministrative claims databaseInherited thrombophiliaThromboembolic eventsElixhauser Comorbidity IndexAdult patientsVenous thromboembolismImplant survivalVTE riskComorbidity indexClaims databaseHip arthroplastyTotal shoulder arthroplasty in patients with Factor V Leiden
Zehner K, Sanchez J, Dhodapkar M, Modrak M, Luo X, Grauer J. Total shoulder arthroplasty in patients with Factor V Leiden. Journal Of Shoulder And Elbow Surgery 2024 PMID: 38479723, DOI: 10.1016/j.jse.2024.01.041.Peer-Reviewed Original ResearchFactor V LeidenVenous thromboembolismAdverse eventsV LeidenTSA patientsRevision rateProphylactic agentFactor V Leiden patientsVTE prophylactic agentOdds ratioRisk of venous thromboembolismEffective treatment optionOdds of bleeding complicationsDeep vein thrombosisMultivariate logistic regressionEnd-stage glenohumeral osteoarthritisTotal shoulder arthroplastyInherited thrombophiliaBleeding complicationsElixhauser Comorbidity IndexLonger-term outcomesPulmonary embolismProthrombotic stateVein thrombosisAdult patientsOutcomes Following Total Hip Arthroplasty in Patients Who Have Von Willebrand Disease Depend on Postoperative Anticoagulation
Jiang W, Sanchez J, Dhodapkar M, Radford Z, Rubin L, Grauer J. Outcomes Following Total Hip Arthroplasty in Patients Who Have Von Willebrand Disease Depend on Postoperative Anticoagulation. The Journal Of Arthroplasty 2024, 39: 2088-2093. PMID: 38462141, DOI: 10.1016/j.arth.2024.03.004.Peer-Reviewed Original ResearchVon Willebrand diseaseVon Willebrand disease patientsRevision-free survivalVenous thromboembolismAdverse eventsOdds of venous thromboembolismTotal hip arthroplastyIncreased oddsDefects of von Willebrand factorCongenital bleeding disordersPatients to dateQualitative defects of von Willebrand factorPostoperative adverse eventsThrombotic adverse eventsMultivariate logistic regressionAutosomal dominant conditionVon Willebrand factorElixhauser Comorbidity IndexBleeding disordersPostoperative anticoagulationAdult patientsCompare bleedingPrescription patternsQualitative defectsWillebrand disease
2023
Timing of Adverse Events Within 90 Days of Hip Fracture Surgery: A Database Study
Kammien A, Ratnasamy P, Caruana D, Grauer J. Timing of Adverse Events Within 90 Days of Hip Fracture Surgery: A Database Study. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: 245-251. PMID: 36821080, DOI: 10.5435/jaaos-d-22-00368.Peer-Reviewed Original ResearchConceptsHip fracture surgeryTime of diagnosisAdverse eventsFracture surgeryDay 31Hip fracture surgery patientsElixhauser comorbidity index scoreAcute kidney injuryCommon adverse eventsComorbidity Index scorePatients 65 yearsPostoperative day 0Surgical site infectionUrinary tract infectionPostoperative day 30Specific adverse eventsKidney injuryCardiac eventsSurgery patientsTract infectionsVenous thromboembolismSite infectionPatient counselingNotable morbidityDatabase studyIncidental Durotomy After Posterior Lumbar Decompression Surgery Associated With Increased Risk for Venous Thromboembolism
Gouzoulis M, Joo P, Caruana D, Kammien A, Rubio D, Grauer J. Incidental Durotomy After Posterior Lumbar Decompression Surgery Associated With Increased Risk for Venous Thromboembolism. Journal Of The American Academy Of Orthopaedic Surgeons 2023, 31: e445-e450. PMID: 36727948, DOI: 10.5435/jaaos-d-22-00917.Peer-Reviewed Original ResearchConceptsLumbar decompression surgeryPosterior lumbar decompression surgeryRisk of VTEVenous thromboembolismIncidental durotomyDecompression surgeryMultivariate analysisOdds of VTETiming of VTEMore VTEDecompression patientsDurotomy groupPatient demographicsPulmonary embolismAdult patientsDegenerative etiologyBed restLumbar laminectomyPatient recoveryUnivariate analysisSpinal surgeryAdministrative codingDurotomySurgeryPatients
2022
Risk factors for venous thromboembolism following fractures isolated to the foot and ankle fracture
Gouzoulis MJ, Joo PY, Kammien AJ, McLaughlin WM, Yoo B, Grauer JN. Risk factors for venous thromboembolism following fractures isolated to the foot and ankle fracture. PLOS ONE 2022, 17: e0276548. PMID: 36264985, PMCID: PMC9584400, DOI: 10.1371/journal.pone.0276548.Peer-Reviewed Original ResearchConceptsVenous thromboembolismAnkle fracturesFactor V LeidenSurgical treatmentRisk factorsActive cancerV LeidenTiming of VTEPrior venous thromboembolismIsolated footIndependent risk factorDeep vein thrombosisRisk/benefit considerationsMultivariate logistical regressionSpecific fracture patternsElixhauser indexPulmonary embolismVein thrombosisPearlDiver databaseMetatarsal fracturesAppendicular fracturesMale sexSuch injuriesTraumatic injuryChi-square analysisAdverse Events After Posterior Lumbar Fusion Are Not Sufficiently Characterized With 30-day Follow-up: A Database Study
Kammien AJ, Zhu JR, Gillinov SM, Gouzoulis MJ, Grauer JN. Adverse Events After Posterior Lumbar Fusion Are Not Sufficiently Characterized With 30-day Follow-up: A Database Study. Journal Of The American Academy Of Orthopaedic Surgeons 2022, 30: 528-533. PMID: 35234736, DOI: 10.5435/jaaos-d-21-01121.Peer-Reviewed Original ResearchConceptsPosterior lumbar fusionTime of diagnosisAdverse eventsLumbar fusionIndividual adverse outcomesNinety-day ratesAcute kidney injurySurgical site infectionUrinary tract infectionSpecific adverse eventsMultiple adverse eventsPLF patientsKidney injuryCardiac eventsTract infectionsVenous thromboembolismPostoperative periodSite infectionAdverse outcomesPatient counselingAdministrative data setsDatabase studyDay 0Time pointsInterquartile range
2021
Risk Factors for Venous Thromboembolism in Children Undergoing Orthopedic Surgery.
Mets EJ, Pathak N, Galivanche AR, McLynn RP, Frumberg DB, Grauer JN. Risk Factors for Venous Thromboembolism in Children Undergoing Orthopedic Surgery. Orthopedics 2021, 45: 31-37. PMID: 34846239, DOI: 10.3928/01477447-20211124-06.Peer-Reviewed Original ResearchConceptsVenous thromboembolismAdverse eventsRisk factorsOrthopedic surgeryNational Surgical Quality Improvement Program Pediatric databaseSurgeons National Surgical Quality Improvement Program Pediatric databaseIncidence of VTEPostoperative venous thromboembolismMinor adverse eventsPostoperative adverse eventsPreoperative blood transfusionIndependent risk factorMajor adverse eventsHigh-risk subpopulationsVTE prophylaxisPerioperative outcomesPatient demographicsBlood transfusionPatient factorsPediatric patientsSurgical variablesPreventable complicationsFemur fracturesPatient populationRetrospective analysis
2020
Venous thromboembolism in children undergoing surgery: incidence, risk factors and related adverse events
Mets E, McLynn R, Grauer J. Venous thromboembolism in children undergoing surgery: incidence, risk factors and related adverse events. World Journal Of Pediatric Surgery 2020, 3: e000084. PMID: 36474866, PMCID: PMC9716836, DOI: 10.1136/wjps-2019-000084.Peer-Reviewed Original ResearchPostoperative venous thromboembolismVenous thromboembolismAdverse eventsSurgical factorsRisk factorsNational Surgical Quality Improvement Project Pediatric databaseSubsequent venous thromboembolismPerioperative adverse eventsPostoperative adverse outcomesRelated adverse eventsRetrospective cohort analysisLonger operative timePediatric surgical patientsPediatric surgical populationPreventable adverse eventsNon-elective surgeryAnesthesiologists classSurgical populationVTE eventsSurgical patientsPediatric patientsTrauma patientsOperative timeAdverse outcomesCardiothoracic surgery
2018
Longer Operative Time Is Associated With Increased Adverse Events After Anterior Cervical Diskectomy and Fusion: 15-Minute Intervals Matter.
Ondeck NT, Bohl DD, McLynn RP, Cui JJ, Bovonratwet P, Singh K, Grauer JN. Longer Operative Time Is Associated With Increased Adverse Events After Anterior Cervical Diskectomy and Fusion: 15-Minute Intervals Matter. Orthopedics 2018, 41: e483-e488. PMID: 29708570, DOI: 10.3928/01477447-20180424-02.Peer-Reviewed Original ResearchConceptsAnterior cervical diskectomyOperative timeAdverse eventsCervical diskectomyPerioperative outcomesSurgical durationSurgeons National Surgical Quality Improvement ProgramNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramIndividual adverse outcomesPostoperative adverse eventsLonger operative timeGreater operative timeQuality Improvement ProgramUnplanned intubationHospital stayBaseline characteristicsVenous thromboembolismHospital readmissionAdverse outcomesPatient variablesAmerican CollegeAnesthetic effectSurgical pathologyPhysiologic stressInaccuracies in ICD Coding for Obesity Would Be Expected to Bias Administrative Database Spine Studies Toward Overestimating the Impact of Obesity on Perioperative Adverse Outcomes
McLynn RP, Geddes BJ, Cui JJ, Ondeck NT, Bovonratwet P, Shultz BN, Grauer JN. Inaccuracies in ICD Coding for Obesity Would Be Expected to Bias Administrative Database Spine Studies Toward Overestimating the Impact of Obesity on Perioperative Adverse Outcomes. Spine 2018, 43: 526-532. PMID: 28767639, DOI: 10.1097/brs.0000000000002356.Peer-Reviewed Original ResearchConceptsBody mass indexMajor adverse eventsAdverse eventsICD codesVenous thromboembolismElective posterior lumbar fusionGreater body mass indexPerioperative adverse outcomesPostoperative adverse eventsRetrospective cohort studyAssociation of obesityImpact of obesityLength of stayPosterior lumbar fusionLarge academic hospitalSpine surgery literaturePostoperative complicationsPostoperative factorsCohort studyMass indexAdverse outcomesLumbar fusionAcademic hospitalBACKGROUND DATASpine studies
2017
Risk factors and pharmacologic prophylaxis for venous thromboembolism in elective spine surgery
McLynn RP, Diaz-Collado PJ, Ottesen TD, Ondeck NT, Cui JJ, Bovonratwet P, Shultz BN, Grauer JN. Risk factors and pharmacologic prophylaxis for venous thromboembolism in elective spine surgery. The Spine Journal 2017, 18: 970-978. PMID: 29056565, DOI: 10.1016/j.spinee.2017.10.013.Peer-Reviewed Original ResearchConceptsElective spine surgeryPrior venous thromboembolismPharmacologic prophylaxisVenous thromboembolismAssociation of patientSpine surgeryRisk factorsUnfractionated heparinVTE prophylaxisInstitutional cohortNational Surgical Quality Improvement Program databaseElective spine surgery patientsRate of VTEQuality Improvement Program databaseDependent functional statusPerioperative blood transfusionRetrospective cohort studySpine surgery patientsImprovement Program databaseIndependent risk factorRetrospective cohort analysisIncidence of hematomaLonger operative timeLumbar spine surgerySingle-institution cohort