2015
Macrophage Activation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
Schupp J, Binder H, Jäger B, Cillis G, Zissel G, Müller-Quernheim J, Prasse A. Macrophage Activation in Acute Exacerbation of Idiopathic Pulmonary Fibrosis. PLOS ONE 2015, 10: e0116775. PMID: 25590613, PMCID: PMC4295887, DOI: 10.1371/journal.pone.0116775.Peer-Reviewed Original ResearchMeSH KeywordsAgedCase-Control StudiesChemokine CXCL1Chemokines, CCFemaleHumansIdiopathic Pulmonary FibrosisInterleukinsMacrophage ActivationMaleMiddle AgedNeutrophilsTumor Necrosis Factor-alphaConceptsIdiopathic pulmonary fibrosisAcute exacerbationBAL cellsMacrophage activationPulmonary fibrosisIL-8M2 cytokinesAE of IPFBAL differential cell countsFuture acute exacerbationsM2 macrophage activationCytokine production levelsDifferential cell countsHigher baseline levelsPatients wSerial lavagesBAL neutrophilsCytokine profileNeutrophil countStable patientsDisease accelerationCCL18 levelsInitial diagnosisIL-1raIL-1β
2010
Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis
Prasse A, Zissel G, Lützen N, Schupp J, Schmiedlin R, Gonzalez-Rey E, Rensing-Ehl A, Bacher G, Cavalli V, Bevec D, Delgado M, Müller-Quernheim J. Inhaled Vasoactive Intestinal Peptide Exerts Immunoregulatory Effects in Sarcoidosis. American Journal Of Respiratory And Critical Care Medicine 2010, 182: 540-548. PMID: 20442436, DOI: 10.1164/rccm.200909-1451oc.Peer-Reviewed Original ResearchConceptsVasoactive intestinal peptideRegulatory T cellsT cellsImmunoregulatory effectsImmunoregulatory roleLung disordersVIP treatmentCapacity of VIPChronic inflammatory lung disordersPeripheral regulatory T cellsTumor necrosis factor-alpha productionClinical phase II studyNecrosis factor-alpha productionConventional effector T cellsEpitheloid cell granulomasFatal organ dysfunctionPhase II studyEffector T cellsExaggerated immune responseChronic lung inflammationInflammatory lung disordersBronchoalveolar lavage fluidNew therapeutic principleImportant immunoregulatory roleActive disease