Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses
Franco L, Gadkari M, Howe K, Sun J, Kardava L, Kumar P, Kumari S, Hu Z, Fraser I, Moir S, Tsang J, Germain R. Immune regulation by glucocorticoids can be linked to cell type–dependent transcriptional responses. Journal Of Experimental Medicine 2019, 216: 384-406. PMID: 30674564, PMCID: PMC6363437, DOI: 10.1084/jem.20180595.Peer-Reviewed Original ResearchConceptsCell typesHuman cell typesPrimary human cell typesCell-specific effectsTranscriptional outputTranscriptional regulationTranscriptional responseIndividual genesB cell receptorNew mechanistic understandingTranscriptional effectsImmunomodulatory cytokine IL-10Toll-like receptor 7Cytokine IL-10Immunoglobulin lociAnti-inflammatory drugsFunctional studiesMechanistic understandingBlimp-1Immunoregulatory therapyIL-10GenesCell receptorReceptor 7Glucocorticoid action