John Davis
Associate Research Scientist in NeurosurgeryCards
About
Research
Publications
2021
Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells
Kim T, Puckett S, Zhang K, Herpai D, Ornelles D, Davis J, van den Pol A, Debinski W, Lyles D. Diversity in responses to oncolytic Lassa-vesicular stomatitis virus in patient-derived glioblastoma cells. Molecular Therapy Oncology 2021, 22: 232-244. PMID: 34514102, PMCID: PMC8424128, DOI: 10.1016/j.omto.2021.06.003.Peer-Reviewed Original ResearchGreen fluorescent proteinGlioblastoma cell linesCell deathCell linesLevels of viral gene expressionViral gene expressionExpression of interferon-stimulated genesLassa virus glycoproteinInterferon-stimulated genesRNA-seqIndividual cell linesLow passagePatient-derived cellsPatient-derived glioblastoma cellsExpressing green fluorescent proteinRNA sequencingInterferon pathway activationFluorescent proteinGene expressionGlioma stem-like cellsStem-like cellsStomatitis virusCell viability assayBrain Tumor CenterSusceptible cells
2020
Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response
van den Pol A, Zhang X, Lima E, Pitruzzello M, Albayrak N, Alvero A, Davis J, Mor G. Lassa-VSV chimeric virus targets and destroys human and mouse ovarian cancer by direct oncolytic action and by initiating an anti-tumor response. Virology 2020, 555: 44-55. PMID: 33453650, PMCID: PMC8451984, DOI: 10.1016/j.virol.2020.10.009.Peer-Reviewed Original ResearchConceptsOvarian cancer cellsHuman ovarian cancer cellsLong-term survivalOvarian cancerCancer cellsTreatment of immunocompetent miceKill ovarian cancer cellsMouse ovarian cancer cellsTreatment of ovarian cancerAnti-tumor responsesImmunocompromised nude miceOncolytic actionImmunocompetent miceMetastatic spreadChemotherapeutic paclitaxelFemale cancersPoor survivalNude miceIntraperitoneal injectionCancer growthSurvival extensionVesicular stomatitis virusVSV glycoproteinCancerReduced neurotropismMucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors
Zhang X, Zhang T, Davis JN, Marzi A, Marchese AM, Robek MD, van den Pol AN. Mucin-Like Domain of Ebola Virus Glycoprotein Enhances Selective Oncolytic Actions against Brain Tumors. Journal Of Virology 2020, 94: 10.1128/jvi.01967-19. PMID: 32051271, PMCID: PMC7108827, DOI: 10.1128/jvi.01967-19.Peer-Reviewed Original ResearchConceptsChimeric vesicular stomatitis virusVSV-EBOVNormal brain cellsBrain tumorsVesicular stomatitis virusEBOV glycoproteinEbola virus glycoproteinEbola virusBrain cellsNormal immunocompetent miceBrain tumor-bearing miceImmunodeficient SCID miceTumor-bearing miceHuman brain tumorsSCID mouse brainStomatitis virusTranscription-quantitative PCRMost tumor cellsVirus glycoproteinOncolytic actionImmune system evasionImmunocompetent miceWild-type vesicular stomatitis virusSCID miceVirus infection
2017
Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain
van den Pol AN, Mao G, Chattopadhyay A, Rose JK, Davis JN. Chikungunya, Influenza, Nipah, and Semliki Forest Chimeric Viruses with Vesicular Stomatitis Virus: Actions in the Brain. Journal Of Virology 2017, 91: 10.1128/jvi.02154-16. PMID: 28077641, PMCID: PMC5331823, DOI: 10.1128/jvi.02154-16.Peer-Reviewed Original ResearchConceptsAdult mouse brainVesicular stomatitis virusVSV glycoprotein (G) geneAdult brainChimeric virusesOncolytic virusesVirus-like vesiclesChimeric vesicular stomatitis virusMouse brainSemliki Forest virusStomatitis virusPostnatal day 14 miceHealthy adult mouse brainRecombinant vesicular stomatitis virusKey immune mechanismsType I interferon responseG glycoproteinI interferon responseInterferon-stimulated genesDay 14 miceInfluenza H5N1 virusGlycoprotein geneNeurotropic natureIntranasal inoculationWild-type vesicular stomatitis virusZika Virus Targeting in the Developing Brain
van den Pol AN, Mao G, Yang Y, Ornaghi S, Davis JN. Zika Virus Targeting in the Developing Brain. Journal Of Neuroscience 2017, 37: 2161-2175. PMID: 28123079, PMCID: PMC5338758, DOI: 10.1523/jneurosci.3124-16.2017.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, NewbornAntiviral AgentsBrainCell Line, TransformedCells, CulturedDisease Models, AnimalGene Expression Regulation, ViralHumansImmunocompromised HostInterferonsMental DisordersMiceMice, TransgenicNervous System DiseasesNeurogliaNeuronsReceptors, InterferonZika VirusZika Virus InfectionConceptsZika virusPeripheral inoculationZIKV infectionSomatosensory cortexType 1 interferon responseContralateral somatosensory cortexSecond trimester human fetusesEarly neonatal stageDay of birthNormal mouse brainSerious neurological problemsMidline brain regionsDevelopmental mouse modelAstrocyte infectionRNA flavivirusInfected astrocytesCortical thinningOptic tractImmunocompetent miceLateral geniculateRetinal neuronsGlial cellsMouse modelNeurological problemsNewborn mice
2016
Mood stabilizers inhibit cytomegalovirus infection
Ornaghi S, Davis JN, Gorres KL, Miller G, Paidas MJ, van den Pol AN. Mood stabilizers inhibit cytomegalovirus infection. Virology 2016, 499: 121-135. PMID: 27657833, PMCID: PMC5102808, DOI: 10.1016/j.virol.2016.09.012.Peer-Reviewed Original ResearchConceptsCytomegalovirus infectionAvailable anti-CMV drugsAnti-CMV drugsCommon infectious causeCongenital birth defectsInfected newbornsFetal exposureInfectious causesInfected fetusesMood stabilizersMouse CMVMood disordersImmunocompromised individualsPsychiatric disordersBody weightViral resistanceHuman CMVDevelopmental maturationBirth defectsSpecific inhibitionCMVInfectionValnoctamideDisordersDrugs
2015
Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors
Wollmann G, Drokhlyansky E, Davis JN, Cepko C, van den Pol AN. Lassa-Vesicular Stomatitis Chimeric Virus Safely Destroys Brain Tumors. Journal Of Virology 2015, 89: 6711-6724. PMID: 25878115, PMCID: PMC4468483, DOI: 10.1128/jvi.00709-15.Peer-Reviewed Original ResearchConceptsLymphocytic choriomeningitis virusBrain tumorsVesicular stomatitis virusChimeric virusesBrain cancerLassa virusEbola virusMarburg virusRabies virusAdverse neurologic consequencesExquisite tumor specificityHigh-grade tumorsPromising oncolytic virusLassa virus glycoprotein precursorAdverse side effectsTumor-bearing miceMetastatic cancer modelsStomatitis virusNovel chimeric virusHigh-grade glioblastomaEbola virus glycoproteinMultiple cancer typesNoninjected tumorNeurologic consequencesOncolytic potential
2013
Vesicular Stomatitis Virus Variants Selectively Infect and Kill Human Melanomas but Not Normal Melanocytes
Wollmann G, Davis JN, Bosenberg MW, van den Pol AN. Vesicular Stomatitis Virus Variants Selectively Infect and Kill Human Melanomas but Not Normal Melanocytes. Journal Of Virology 2013, 87: 6644-6659. PMID: 23552414, PMCID: PMC3676084, DOI: 10.1128/jvi.03311-12.Peer-Reviewed Original ResearchConceptsVesicular stomatitis virusReplication-competent vesicular stomatitis virusMetastatic malignant melanomaRecombinant vesicular stomatitis virusMouse melanoma modelHuman melanoma samplesGene mutation statusVSV-CT9Low viral concentrationsMelanoma typesMalignant melanomaSCID miceViral oncolysisMelanoma xenograftsViral infectionMelanoma modelMutation statusMalignant transformationHuman melanomaInfectionMelanomaVirus variantsComplete protectionMelanoma samplesGene mutations
2012
Highly Attenuated Recombinant Vesicular Stomatitis Virus VSV-12′GFP Displays Immunogenic and Oncolytic Activity
van den Pol A, Davis J. Highly Attenuated Recombinant Vesicular Stomatitis Virus VSV-12′GFP Displays Immunogenic and Oncolytic Activity. Journal Of Virology 2012, 87: 1019-1034. PMID: 23135719, PMCID: PMC3554062, DOI: 10.1128/jvi.01106-12.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression ProfilingGenes, ReporterGliomaGreen Fluorescent ProteinsHumansMiceMice, SCIDMolecular Sequence DataOncolytic VirusesRNA, ViralSequence Analysis, DNASurvival AnalysisTreatment OutcomeVaccines, AttenuatedVaccines, SyntheticVesiculovirusViral Plaque AssayViral VaccinesConceptsVesicular stomatitis virusGreen fluorescent proteinReporter geneOne-step growth curveVesicular stomatitis virus genomeAttenuated vesicular stomatitis virusCancer cellsHigh-titer antibody responsesInjection of tumorHuman cancer cellsSuppressed tumor growthRNA transcriptsOncolytic virusesIntratumoral injectionSCID micePostnatal daySafety profileFluorescent proteinTumor growthVSV-G/GFPGenesRecombinant virusesStomatitis virusImmune responseAntibody response
2009
Viral Mutagenesis as a Means for Generating Novel Proteins
Davis J, van den Pol A. Viral Mutagenesis as a Means for Generating Novel Proteins. Journal Of Virology 2009, 84: 1625-1630. PMID: 19906913, PMCID: PMC2812339, DOI: 10.1128/jvi.01747-09.Peer-Reviewed Original Research
News
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- November 08, 2015
Yale Medical Group welcomes its newest physicians
- June 14, 2013
Fast-acting virus targets melanoma in mice
- February 07, 2010
Yale Scientists Shed Colorful Light On Novel Proteins