1997
Effect of alpha-methyl-para-tyrosine on response to cocaine challenge
Stine S, Krystal J, Petrakis I, Jatlow P, Heninger G, Kosten T, Chamey D. Effect of alpha-methyl-para-tyrosine on response to cocaine challenge. Biological Psychiatry 1997, 42: 181-190. PMID: 9232210, DOI: 10.1016/s0006-3223(96)00331-9.Peer-Reviewed Original ResearchConceptsDopamine metabolite homovanillic acidCocaine-induced euphoriaNorepinephrine metabolite 3Placebo-controlled studyBlood pressure responseMetabolite homovanillic acidReduced plasma levelsTyrosine hydroxylase inhibitorSerum cocaine levelsTuberoinfundibular dopamine systemAMPT pretreatmentAcute reductionIntranasal administrationPara-tyrosinePlasma levelsProlactin levelsCocaine challengeHomovanillic acidCatecholamine synthesisHeart rateHydroxylase inhibitorAlpha-methylDopamine systemCocaine levelsTherapeutic potential
1996
AMPT Effects on Cue‐Induced Craving for Cocaine
Petrakis I, Satel S, Stine S, Kosten T, Namanworth S, Charney D, Krystal J. AMPT Effects on Cue‐Induced Craving for Cocaine. American Journal On Addictions 1996, 5: 313-320. DOI: 10.1111/j.1521-0391.1996.tb00317.x.Peer-Reviewed Original ResearchCue-induced cravingCue exposure sessionsDouble-blind conditionsCocaine-dependent patientsNorepinephrine metaboliteAcute reductionPara-tyrosineDopamine metabolitesPlasma levelsHomovanillic acidSelf-report assessmentsCatecholamine synthesisCocaine cravingCrossover designExposure sessionsCue exposureCravingDiphenhydramineCocaine
1991
Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study
Satel SL, Price LH, Palumbo JM, McDougle CJ, Krystal JH, Gawin F, Charney DS, Heninger GR, Kleber HD. Clinical phenomenology and neurobiology of cocaine abstinence: a prospective inpatient study. American Journal Of Psychiatry 1991, 148: 1712-1716. PMID: 1957935, DOI: 10.1176/ajp.148.12.1712.Peer-Reviewed Original ResearchConceptsHomovanillic acidGrowth hormoneRating ScaleGH valuesNormal subjectsCentral dopamine functionProspective inpatient studySerial blood samplesVisual analog scaleDSM-III-R cocaine dependenceSignificant decreaseSymptom Rating ScaleShort clinical rating scalesClinical rating scalesBeck Depression InventoryPhysical Symptoms ScalePatients prolactinInpatient managementSuch patientsAnalog scaleInpatient studyDopaminergic functionPatient levelBlood samplesPharmacological agents