2025
Gamma oscillations and excitation/inhibition imbalance: parallel effects of N-methyl D-aspartate receptor antagonism and psychosis
Roach B, Ford J, Nicholas S, Ferri J, Gunduz-Bruce H, Krystal J, Jaeger J, Mathalon D. Gamma oscillations and excitation/inhibition imbalance: parallel effects of N-methyl D-aspartate receptor antagonism and psychosis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2025 PMID: 39832734, DOI: 10.1016/j.bpsc.2025.01.008.Peer-Reviewed Original ResearchN-methyl-D-aspartate glutamate receptorAuditory steady-state responsePhase-locking factorBroadband gamma powerGamma powerNMDAR hypofunctionAcute administration of ketamineN-methyl-D-aspartate glutamate receptor antagonistEvoked powerN-methyl-D-aspartate receptor antagonismDrug challenge studiesReplicate previous findingsReplicate prior studiesAdministration of ketamineHealthy control subjectsComparison of patientsSchizophrenia patientsAcute administrationSchizophreniaExcitation/inhibition imbalanceStudy 1Study 2Gamma oscillationsReceptor antagonismEEG studies
1995
Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT)
Krystal J, Woods S, Kosten T, Rosen M, Seibyl J, Van Dyck C, Price L, Zubal I, Hoffer P, Charney D. Opiate Dependence and Withdrawal: Preliminary Assessment Using Single Photon Emission Computerized Tomography (SPECT). The American Journal Of Drug And Alcohol Abuse 1995, 21: 47-63. PMID: 7762544, DOI: 10.3109/00952999509095229.Peer-Reviewed Original ResearchConceptsRegional brain functionOpiate withdrawal signsSingle Photon Emission Computerized TomographyHealthy subjectsNaloxone administrationOpiate withdrawalOpiate dependenceBrain functionParietal cortexHexamethylpropyleneamine oximeWithdrawal signsNaloxone effectChronic opiate dependencePlacebo-controlled studyRegional alterationsComparison of patientsMethadone-maintained patientsRegional cerebral perfusionPhoton Emission Computerized TomographyOpiate-dependent patientsRight temporal cortexRight parietal cortexFunctional brain imaging technologiesSingle photon emissionEmission computerized tomography