Featured Publications
2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients
Forrest JK, Deeb GM, Yakubov SJ, Rovin JD, Mumtaz M, Gada H, O'Hair D, Bajwa T, Sorajja P, Heiser JC, Merhi W, Mangi A, Spriggs DJ, Kleiman NS, Chetcuti SJ, Teirstein PS, Zorn GL, Tadros P, Tchétché D, Resar JR, Walton A, Gleason TG, Ramlawi B, Iskander A, Caputo R, Oh JK, Huang J, Reardon MJ. 2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients. Journal Of The American College Of Cardiology 2022, 79: 882-896. PMID: 35241222, DOI: 10.1016/j.jacc.2021.11.062.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEvolut Low Risk trialLow-risk trialsAortic valve replacementPrimary endpointRisk trialsCause mortalityValve replacementTranscatheter Versus Surgical Aortic Valve ReplacementLow surgical risk patientsSurgical aortic valve replacementIndependent clinical events committeeEchocardiographic core laboratoryKaplan-Meier ratesSevere aortic stenosisClinical events committeeLow-risk patientsCause mortality ratesSelf-expanding valvesDisabling strokeEchocardiographic outcomesSurgical AVRTAVR groupSurgery groupAdverse events
2024
Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials
Reddy R, Howard J, Reardon M, Thyregod H, Jorgensen T, Toff W, Forrest J, Leon M, Ahmad Y. Transcatheter versus surgical aortic valve replacement in lower-risk patients: an updated meta-analysis of randomised controlled trials. European Heart Journal 2024, 45: ehae666.2456. DOI: 10.1093/eurheartj/ehae666.2456.Peer-Reviewed Original ResearchLower-risk patientsIndividual patient dataFollow-upNo significant differenceClinical outcomesPairwise random-effects meta-analysesNew-onset atrial fibrillationLong-term clinical outcomesSurgical aortic valve replacementKaplan-Meier survival curvesMeta-analysis of randomised controlled trialsLow-surgical riskMeta-analysesAortic valve reinterventionReconstructed individual patient dataLow surgical riskAortic valve replacementFollow-up durationSevere aortic stenosisMeta-analysisSignificant differenceCox proportional hazards regressionComposite of deathKaplan-Meier plotsLonger-term follow-upThree-Year Outcomes Following TAVR in Younger (<75 Years) Low-Surgical-Risk Severe Aortic Stenosis Patients.
Modine T, Tchétché D, Van Mieghem N, Deeb G, Chetcuti S, Yakubov S, Sorajja P, Gada H, Mumtaz M, Ramlawi B, Bajwa T, Crouch J, Teirstein P, Kleiman N, Iskander A, Bagur R, Chu M, Berthoumieu P, Sudre A, Adrichem R, Ito S, Huang J, Popma J, Forrest J, Reardon M. Three-Year Outcomes Following TAVR in Younger (<75 Years) Low-Surgical-Risk Severe Aortic Stenosis Patients. Circulation Cardiovascular Interventions 2024, e014018. PMID: 39421943, DOI: 10.1161/circinterventions.124.014018.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementSelf-expanding transcatheter aortic valve replacementLow-risk patientsPatients aged <Society of Thoracic Surgeons Predicted Risk of MortalityRandomized to TAVRRate of severe prosthesis-patient mismatchSupra-annularThoracic Surgeons Predicted Risk of MortalityEvolut Low Risk TrialIncidence of disabling strokePatients treated with transcatheter aortic valve replacementRate of valve thrombosisSevere prosthesis-patient mismatchPatients treated with surgeryDisabling strokeIncidence of pacemaker implantationSevere aortic stenosis patientsRates of all-cause mortalityProsthesis-patient mismatchAortic valve replacementSevere aortic stenosisAortic stenosis patientsPatients to treatmentAll-cause mortality3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study
Zahr F, Ramlawi B, Reardon M, Deeb G, Yakubov S, Song H, Kleiman N, Chetcuti S, Gada H, Mumtaz M, Leung S, Merhi W, Rovin J, DeFrain M, Muppala M, Kauten J, Rajagopal V, Huang J, Ito S, Forrest J. 3-Year Outcomes From the Evolut Low Risk TAVR Bicuspid Study. JACC Cardiovascular Interventions 2024, 17: 1667-1675. PMID: 39048253, DOI: 10.1016/j.jcin.2024.05.017.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBicuspid Aortic Valve DiseaseBioprosthesisFemaleHeart Valve DiseasesHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProspective StudiesProsthesis DesignRecovery of FunctionRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsTranscatheter aortic valve replacementRates of all-cause mortalityAll-cause mortalityAortic stenosisThoracic Surgeons Predicted Risk of Mortality scoreThoracic Surgeons Predicted RiskSevere paravalvular aortic regurgitationBicuspid aortic valve anatomyRisk of Mortality scoreEchocardiographic core laboratoryLow-surgical risk patientsAortic valve anatomyKaplan-Meier ratesLow surgical riskClinical events committeeAortic valve replacementSevere aortic stenosisParavalvular aortic regurgitationPermanent pacemaker implantationBicuspid aortic stenosisFavorable hemodynamic performanceEvaluated 3 yearsAttempted implantEchocardiographic outcomesAortic regurgitationTranscatheter or Surgical Aortic Valve Replacement in Women With Small Annuli at Low or Intermediate Surgical Risk
Modine T, Forrest J, Van Mieghem N, Deeb G, Yakubov S, Ali W, Tchétché D, Lam K, Oh J, Huang J, Mehran R, Reardon M. Transcatheter or Surgical Aortic Valve Replacement in Women With Small Annuli at Low or Intermediate Surgical Risk. The American Journal Of Cardiology 2024, 223: 147-155. PMID: 38641189, DOI: 10.1016/j.amjcard.2024.04.013.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementIntermediate surgical riskValve replacementSurgical riskAortic stenosisTranscatheter aortic valve replacement groupImpact of transcatheter aortic valve replacementSurgical aortic valve replacementMid-term clinical outcomesPatient-prothesis mismatchSmall aortic annulusMidterm clinical outcomesSevere aortic stenosisSelf-expandingEffective orifice areaAll-cause mortalityEvaluated 2 yearsPost hoc analysisRandomized controlled trialsAortic annulusSurgical groupPrimary endpointHemodynamic outcomesClinical outcomes
2023
Three-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis
Modine T, Tchetche D, Van Mieghem N, Huang J, Forrest J, Reardon M. Three-year outcomes following transcatheter versus surgical aortic valve replacement in younger, low surgical risk patients with severe aortic stenosis. European Heart Journal 2023, 44: ehad655.1713. DOI: 10.1093/eurheartj/ehad655.1713.Peer-Reviewed Original ResearchTranscatheter aortic valve implantationSevere aortic stenosisSelf-expanding transcatheter aortic valve implantationLow-risk patientsAortic stenosisRisk patientsLower riskCause mortalityPrimary endpointYounger patientsLower incidenceLow surgical risk patientsSurgical aortic valve replacementGreater paravalvular regurgitationSurgical risk patientsAortic stenosis patientsAortic valve replacementIntermediate-term outcomesLow surgical riskAortic valve implantationThree-Year OutcomesEffective orifice areaYears of ageAortic gradientEchocardiographic outcomesTCT-133 Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis
Grubb K, Lisko J, O’Hair D, Merhi W, Forrest J, Mahoney P, van Mieghem N, Windecker S, Yakubov S, Chetcuti S, Deeb G, Kleiman N, Althouse A, Reardon M. TCT-133 Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis. Journal Of The American College Of Cardiology 2023, 82: b52. DOI: 10.1016/j.jacc.2023.09.139.Peer-Reviewed Original ResearchSevere aortic stenosis detection by deep learning applied to echocardiography
Holste G, Oikonomou E, Mortazavi B, Coppi A, Faridi K, Miller E, Forrest J, McNamara R, Ohno-Machado L, Yuan N, Gupta A, Ouyang D, Krumholz H, Wang Z, Khera R. Severe aortic stenosis detection by deep learning applied to echocardiography. European Heart Journal 2023, 44: 4592-4604. PMID: 37611002, PMCID: PMC11004929, DOI: 10.1093/eurheartj/ehad456.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisImpact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis
Ito S, Laham R, Nkomo V, Forrest J, Reardon M, Little S, Mumtaz M, Gada H, Bajwa T, Langholz D, Heiser J, Chawla A, Jenson B, Attizanni G, Markowitz A, Huang J, Oh J. Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis. Open Heart 2023, 10: e002297. PMID: 37173100, PMCID: PMC10186477, DOI: 10.1136/openhrt-2023-002297.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementAortic stenosisSymptomatic patientsValve replacementKansas City Cardiomyopathy Questionnaire overall summary scoreEvolut Low Risk trialSurgical aortic valve replacementLow-risk trialsLow-risk patientsOverall summary scoreRate of deathQuality of lifeDisabling strokeEchocardiographic evidenceIsolated AVRHaemodynamic profileClinical outcomesHaemodynamic outcomesRisk trialsClinical trialsCalcium volumeSummary scoresPatientsCore laboratory measurementsCerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial dataTranscatheter Aortic Valve Replacement in Large Annuli Valves With the Supra-Annular, Self-Expandable Evolut Platform in a Real-World Registry
Dallan L, Tang G, Forrest J, Reardon M, Szeto W, Kodali S, Baeza C, Eisenberg R, Attizzani G. Transcatheter Aortic Valve Replacement in Large Annuli Valves With the Supra-Annular, Self-Expandable Evolut Platform in a Real-World Registry. Circulation Cardiovascular Interventions 2023, 16: e012623. PMID: 36943929, PMCID: PMC10022658, DOI: 10.1161/circinterventions.122.012623.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementCardiology Transcatheter Valve Therapy RegistryThoracic Surgeons/American CollegeTranscatheter Valve Therapy RegistryValve replacementAortic stenosisAmerican CollegeMultivariable Cox proportional hazards regression modelsAnnulus sizeCox proportional hazards regression modelProportional hazards regression modelsAortic valve reinterventionTricuspid aortic stenosisReal-world registrySevere aortic stenosisBetter clinical outcomesTreatment of patientsHazards regression modelsComputed tomography angiographyLarge annulusValve reinterventionCause mortalityReadmission ratesValve procedures
2022
Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials
Ahmad Y, Howard J, Seligman H, Arnold A, Madhavan M, Forrest J, Geirsson A, Mack M, Lansky A, Leon M. Early Surgery for Patients With Asymptomatic Severe Aortic Stenosis: A Meta-Analysis of Randomized Controlled Trials. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100383. PMID: 39131941, PMCID: PMC11307849, DOI: 10.1016/j.jscai.2022.100383.Peer-Reviewed Original ResearchSurgical aortic valve replacementAsymptomatic severe aortic stenosisSevere aortic stenosisAortic stenosisHF hospitalizationCause mortalityEjection fractionPrespecified primary end pointSevere asymptomatic aortic stenosisSymptomatic severe aortic stenosisEnd pointAortic valve interventionAsymptomatic aortic stenosisHeart failure hospitalizationPrimary end pointAortic valve replacementClass I recommendationCornerstone of managementInitial conservative managementNormal ejection fractionRandomized Controlled TrialsCurrent treatment standardsIndividual end pointsAsymptomatic patientsEarly surgery
2021
Coronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis
Patel KP, Michail M, Treibel TA, Rathod K, Jones DA, Ozkor M, Kennon S, Forrest JK, Mathur A, Mullen MJ, Lansky A, Baumbach A. Coronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis. JACC Cardiovascular Interventions 2021, 14: 2083-2096. PMID: 34620388, DOI: 10.1016/j.jcin.2021.07.058.Peer-Reviewed Original ResearchConceptsAortic valve replacementCoronary artery diseaseAortic stenosisHemodynamic statusCoronary revascularizationValve replacementAssessment of CADPatients Undergoing Aortic Valve ReplacementConcomitant coronary artery diseaseImpact of ASSignificant coronary artery diseaseConcomitant aortic stenosisRole of revascularizationSevere aortic stenosisThird of patientsCohort of patientsDual pathologyArtery diseaseTherapeutic challengeCertain patientsMyocardial ischemiaCoronary assessmentPatientsRevascularizationMultidisciplinary team
2020
Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement
Saito Y, Nazif T, Baumbach A, Tchétché D, Latib A, Kaple R, Forrest J, Prendergast B, Lansky A. Adjunctive Antithrombotic Therapy for Patients With Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement. JAMA Cardiology 2020, 5: 92-101. PMID: 31721980, DOI: 10.1001/jamacardio.2019.4367.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementAdjunctive antithrombotic therapyDual antiplatelet therapyAntithrombotic therapyAntiplatelet therapyValve replacementAortic stenosisAortic stenosis (AS) undergoing transcatheter aortic valve replacementSevere symptomatic aortic stenosisSurgical aortic valve replacementGuideline-recommended regimenOral anticoagulant useSevere aortic stenosisSingle antiplatelet therapySymptomatic aortic stenosisPatient risk factorsOngoing clinical trialsRisk prediction modelMajor bleedingOral anticoagulationAnticoagulant useStroke riskTAVR proceduresThrombotic risk
2019
600.03 Self-Expanding Transcatheter Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Bicuspid Morphology: A Report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy RegistryTM
Forrest J, Ramlawi B, Popma J, Reardon M. 600.03 Self-Expanding Transcatheter Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Bicuspid Morphology: A Report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy RegistryTM. JACC Cardiovascular Interventions 2019, 12: s43. DOI: 10.1016/j.jcin.2019.01.155.Peer-Reviewed Original ResearchSelf-expanding transcatheter aortic valve replacementThoracic Surgeons/American CollegeTranscatheter aortic valve replacementAortic valve replacementSevere aortic stenosisTranscatheter valve therapiesValve replacementAortic stenosisValve therapyBicuspid morphologyAmerican CollegeStenosisPatientsTherapyCardiac Biomarkers in Transcatheter Aortic Valve Implantation
Hermany P, Forrest J. Cardiac Biomarkers in Transcatheter Aortic Valve Implantation. 2019, 147-164. DOI: 10.1007/978-3-030-05912-5_13.Peer-Reviewed Original ResearchAortic valve replacementValve replacementMyocardial injuryCardiac proceduresCardiac biomarkersTranscatheter aortic valve implantationTranscatheter aortic valve replacementAortic stenosis managementSevere aortic stenosisAortic valve implantationCardiac biomarker releaseStandard of careAppropriate clinical applicationValve implantationAortic stenosisSuch patientsHemodynamic alterationsAdverse outcomesBiomarker releaseCardiac conditionsTAVRNovel markerPatientsCardiac physiologyBiomarkers
2016
Relationship of Annular Sizing Using Multidetector Computed Tomographic Imaging and Clinical Outcomes After Self-Expanding CoreValve Transcatheter Aortic Valve Replacement
Popma JJ, Gleason TG, Yakubov SJ, Harrison JK, Forrest JK, Maini B, Ruiz CE, Pinto DS, Costa M, Resar J, Conte J, Crestanello J, Chang Y, Oh JK, Reardon MJ, Adams DH. Relationship of Annular Sizing Using Multidetector Computed Tomographic Imaging and Clinical Outcomes After Self-Expanding CoreValve Transcatheter Aortic Valve Replacement. Circulation Cardiovascular Interventions 2016, 9: e003282. PMID: 27369803, DOI: 10.1161/circinterventions.115.003282.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAlgorithmsAortic ValveAortic Valve InsufficiencyAortic Valve StenosisClinical Decision-MakingDecision Support TechniquesFemaleGuideline AdherenceHeart Valve ProsthesisHumansMaleMultidetector Computed TomographyPatient SelectionPractice Guidelines as TopicPredictive Value of TestsProsthesis DesignRisk FactorsSeverity of Illness IndexTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsParavalvular aortic regurgitationSevere paravalvular aortic regurgitationSevere aortic stenosisAortic regurgitationValve replacementAortic stenosisClinical outcomesCoreValve transcatheter aortic valve replacementTranscatheter aortic valve replacementSuboptimal surgical candidatesAortic valve replacementClinical end pointsTranscatheter valve replacementTranscatheter heart valve (THV) sizeLower ratesHigher DARPreprocedural multidetectorSurgical candidatesClinical eventsRegurgitationEchocardiographic laboratoryPatientsValve sizeAnnulus perimeterTHV sizingTranscatheter Aortic Valve Replacement Versus Surgery in Women at High Risk for Surgical Aortic Valve Replacement (from the CoreValve US High Risk Pivotal Trial)
Skelding KA, Yakubov SJ, Kleiman NS, Reardon MJ, Adams DH, Huang J, Forrest JK, Popma JJ. Transcatheter Aortic Valve Replacement Versus Surgery in Women at High Risk for Surgical Aortic Valve Replacement (from the CoreValve US High Risk Pivotal Trial). The American Journal Of Cardiology 2016, 118: 560-566. PMID: 27381665, DOI: 10.1016/j.amjcard.2016.05.051.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementSevere aortic stenosisValve replacementCause mortalityAortic stenosisHigh riskKansas City Cardiomyopathy Questionnaire summary scoreTAVR-treated patientsSelf-expanding valvesMajor stroke rateSelf-expanding prosthesisQuality of lifeSAVR groupSAVR patientsVersus SurgeryTAVR patientsBaseline characteristicsMajor strokeDiabetes mellitusStroke rateSurvival advantageSummary scoresPatients
2015
Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with cirrhosis
Thakkar B, Patel A, Mohamad B, Patel NJ, Bhatt P, Bhimani R, Patel A, Arora S, Savani C, Solanki S, Sonani R, Patel S, Patel N, Deshmukh A, Mohamad T, Grines C, Cleman M, Mangi A, Forrest J, Badheka AO. Transcatheter aortic valve replacement versus surgical aortic valve replacement in patients with cirrhosis. Catheterization And Cardiovascular Interventions 2015, 87: 955-962. PMID: 26699085, DOI: 10.1002/ccd.26345.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisBlood TransfusionCardiac CatheterizationChi-Square DistributionCross-Sectional StudiesDatabases, FactualFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHospital CostsHumansLength of StayLiver CirrhosisLogistic ModelsMaleMiddle AgedMultivariate AnalysisPostoperative ComplicationsPropensity ScoreRisk FactorsSeverity of Illness IndexTime FactorsTreatment OutcomeUnited StatesConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementAortic valve replacementValve replacementNational Inpatient SampleCirrhosis patientsTAVR groupComplication rateICD-9-CM diagnosis codesICD-9-CM procedureHospital mortality rateSevere aortic stenosisHigh-risk patientsOpen heart surgeryYears of agePostprocedural lengthSAVR groupHospital outcomesOperative morbidityPortal hypertensionAortic stenosisCardiac surgeryCardiopulmonary bypassEsophageal varicesLiver cirrhosis