2017
A receptor and neuron that activate a circuit limiting sucrose consumption
Joseph RM, Sun JS, Tam E, Carlson JR. A receptor and neuron that activate a circuit limiting sucrose consumption. ELife 2017, 6: e24992. PMID: 28332980, PMCID: PMC5388533, DOI: 10.7554/elife.24992.Peer-Reviewed Original Research
2011
Scent of a Human
Carlson JR, Carey AF. Scent of a Human. Scientific American 2011, 305: 76-79. PMID: 21717963, DOI: 10.1038/scientificamerican0711-76.Peer-Reviewed Original Research
2008
A New Drosophila POU Gene, pdm3, Acts in Odor Receptor Expression and Axon Targeting of Olfactory Neurons
Tichy AL, Ray A, Carlson JR. A New Drosophila POU Gene, pdm3, Acts in Odor Receptor Expression and Axon Targeting of Olfactory Neurons. Journal Of Neuroscience 2008, 28: 7121-7129. PMID: 18614681, PMCID: PMC2572001, DOI: 10.1523/jneurosci.2063-08.2008.Peer-Reviewed Original ResearchConceptsPOU genesOlfactory receptor neuronsAxon targetingReceptor gene choiceClasses of ORNsReceptor expressionGenetic interactionsGene choiceGene codesORN classesPdm3Genetic analysisMutational analysisOdor responsesMolecular mechanismsGenesOlfactory neuronsReceptor neuronsIndividual receptorsDifferential activationOlfactory systemProper transmissionExpressionFunctional organizationTargetingTranslation of Sensory Input into Behavioral Output via an Olfactory System
Kreher SA, Mathew D, Kim J, Carlson JR. Translation of Sensory Input into Behavioral Output via an Olfactory System. Neuron 2008, 59: 110-124. PMID: 18614033, PMCID: PMC2496968, DOI: 10.1016/j.neuron.2008.06.010.Peer-Reviewed Original Research
2007
Two Gr Genes Underlie Sugar Reception in Drosophila
Dahanukar A, Lei YT, Kwon JY, Carlson JR. Two Gr Genes Underlie Sugar Reception in Drosophila. Neuron 2007, 56: 503-516. PMID: 17988633, PMCID: PMC2096712, DOI: 10.1016/j.neuron.2007.10.024.Peer-Reviewed Original ResearchConceptsSubset of sugarsReporter gene expressionSugar-sensing neuronsDouble mutantSugar receptionMolecular basisGenetic analysisGene expressionGr5aDrosophilaReceptor geneSitu hybridizationGenesNeuronsGr64aPrimary receptorTaste receptorsDistinct projectionsReceptorsTemporal dynamicsSugarsMutantsBehavioral responsesLabellumReporter
2004
The Molecular Basis of Odor Coding in the Drosophila Antenna
Hallem EA, Ho MG, Carlson JR. The Molecular Basis of Odor Coding in the Drosophila Antenna. Cell 2004, 117: 965-979. PMID: 15210116, DOI: 10.1016/j.cell.2004.05.012.Peer-Reviewed Original ResearchConceptsOlfactory receptor neuronsDrosophila antennaMolecular basisOdorant receptor repertoireFunctional analysisReceptor repertoireOlfactory organOdor codingReceptor neuronsIndividual receptorsSame cellsReceptor transductionNumber of receptorsNeuron mapReceptorsRepertoireBreadth of tuningTransductionDifferent odorantsInhibitory responsesOdorantsElectrophysiological recordingsNeuronsCellsVivo
2001
A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila
Dahanukar A, Foster K, van der Goes van Naters W, Carlson J. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nature Neuroscience 2001, 4: 1182-1186. PMID: 11704765, DOI: 10.1038/nn765.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAnimals, Genetically ModifiedBase SequenceBehavior, AnimalCodonDose-Response Relationship, DrugDrosophilaFood, FormulatedGene DeletionGene Expression RegulationGenetic LinkageGTP-Binding ProteinsMaleMutationNeurons, AfferentPhenotypeProtein BiosynthesisReceptors, Cell SurfaceSucroseTasteTrehaloseX ChromosomeConceptsGR geneG protein-coupled receptor genesSugar trehaloseG protein-mediated signalingDrosophila genome databaseTransgenic rescue experimentsProtein-mediated signalingSpecificity of expressionGenome databaseTaste receptorsDifferent mutantsRescue experimentsGenesLarge familyGr5aDrosophilaFunctional evidenceReceptor geneGR receptorsTaste ligandsGustatory neuronsTaste neuronsTrehaloseReceptorsFamily members
1999
The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor
Clyne P, Certel S, de Bruyne M, Zaslavsky L, Johnson W, Carlson J. The Odor Specificities of a Subset of Olfactory Receptor Neurons Are Governed by Acj6, a POU-Domain Transcription Factor. Neuron 1999, 22: 339-347. PMID: 10069339, DOI: 10.1016/s0896-6273(00)81094-6.Peer-Reviewed Original ResearchConceptsPOU domain transcription factorOlfactory neuronsTranscription factorsIndividual olfactory neuronsOdorant response profilesSubset of neuronsOlfactory receptor neuronsOdor specificityPhysiological analysisAcj6Neuronal identityOlfactory behaviorMolecular analysisReceptor neuronsNeuronsReceptor geneOlfactory codingGenesResponse profilesMutantsSpecificitySubset